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Cited by 1,011

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

On the Crawling of Animal Cells

Stossel, Thomas P.·1993·Science

Abstract

Cells crawl in response to external stimuli by extending and remodeling peripheral elastic lamellae in the direction of locomotion. The remodeling requires vectorial assembly of actin subunits into linear polymers at the lamella's leading edge and the crosslinking of the filaments by bifunctional gelation proteins. The disassembly of the crosslinked filaments into short fragments or monomeric subunits away from the leading edge supplies components for the actin assembly reactions that drive protrusion. Cellular proteins that respond to lipid and ionic signals elicited by sensory cues escort actin through this cycle in which filaments are assembled, crosslinked, and disassembled. One class of myosin molecules may contribute to crawling by guiding sensory receptors to the cell surface, and another class may contribute by imposing contractile forces on actin networks in the lamellae.

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Metadata

Authors
Stossel, T. P.
Venue
Science
Published
1993-05-21
Volume
260
Issue
5111
Pages
1086-1094
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2030463167
Cited by
1,011
References
4
FWCI
34.15
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: On the Crawling of Animal Cells. https://app.cochat.ai/papers/10.1126/science.8493552
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Stossel, T. P. (1993). On the Crawling of Animal Cells. Science. https://doi.org/10.1126/science.8493552

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.