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Expression of Pseudomonas aeruginosa Virulence Genes Requires Cell-to-Cell Communication
Abstract
Pseudomonas aeruginosa is an opportunistic human pathogen that causes a variety of infections in immunocompromised hosts and individuals with cystic fibrosis. Expression of elastase, one of the virulence factors produced by this organism, requires the transcriptional activator LasR. Experiments with gene fusions show that gene lasl is essential for high expression of elastase. The lasl gene is involved in the synthesis of a diffusible molecule termed Pseudomonas autoinducer (PAI). PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches.
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Citations
Cited by
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Self-citationHentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, J. B., Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, N., et al. (2002) · Microbiology · doi:10.1099/00221287-148-1-87 · Cited by 1,050
Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa
Lamont, I. L., Beare, P. A., Ochsner, U., Vasil, A. I., & Vasil, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092016999 · Cited by 584
Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.
(1997) · Europe PMC (PubMed Central) · Cited by 510
Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections
Rumbaugh, K. P., Griswold, J. A., Iglewski, B. H., & Hamood, A. N. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.5854-5862.1999 · Cited by 408
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Metadata
- Authors
- Passador, L., Cook, J. M., Gambello, M. J., Rust, L., & Iglewski, B. H.
- Venue
- Science
- Published
- 1993-05-21
- Volume
- 260
- Issue
- 5111
- Pages
- 1127-1130
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092550686
- Cited by
- 857
- References
- 0
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Passador, L., Cook, J. M., Gambello, M. J., Rust, L., & Iglewski, B. H. (1993). Expression of Pseudomonas aeruginosa Virulence Genes Requires Cell-to-Cell Communication. Science. https://doi.org/10.1126/science.8493556
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
