Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity
Abstract
The binding of [ 3 H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.
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An increase in contralateral rotations could be caused by either abnormal presynaptic axonal dopamine release by SNc DA neurons or hypersensitive postsynaptic D1/D2 dopamine receptors.
“An increase in contralateral rotations could be caused by either abnormal presynaptic axonal dopamine release by SNc DA neurons (Konieczny et al. 2016) and/or hypersensitive postsynaptic D1/D2 dopamine receptors (Creese et al. 1977; Groppetti et al. 1986; Rouillard et al. 1987).”
From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Creese et al. 1977
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Antipsychotic-Induced Dopamine Supersensitivity Psychosis: Pharmacology, Criteria, and Therapy
Chouinard, G., Samaha, A.-N., Chouinard, V.-A., Peretti, C.-S., Kanahara, N., Takase, M., & Iyo, M. (2017) · Psychotherapy and Psychosomatics · doi:10.1159/000477313 · Cited by 270 · see citing works
Neuroleptic-induced supersensitivity psychosis
(1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.11.1409 · Cited by 224 · see citing works
Ayala, D. A., Hall, G. M., Das, D., Tijerina, E., Villagran, L. L., Khan, Z., Paliwal, D., Anand, A., Rimer, M., & Srinivasan, R. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01713-x · Cited by 1 · see citing works
- Authors
- Creese, I., Burt, D. R., & Snyder, S. H.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Snyder, Solomon H.
- Venue
- Science
- Published
- 1977-08-05
- Volume
- 197
- Issue
- 4303
- Pages
- 596-598
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072740414
- Cited by
- 712
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 8 · 2021: 8 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 15.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine receptors, receptor binding, 6-hydroxydopamine lesion, nigrostriatal pathway, striatum, haloperidol, apomorphine-induced rotation, receptor density, receptor binding affinity, dopamine depletion
- MeSH terms
- Animals, Apomorphine, Behavior, Animal, Corpus Striatum, Dopamine, Haloperidol, Hydroxydopamines, Kinetics, Motor Activity, Receptors, Dopamine, Reserpine, Rats
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