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Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products
Abstract
Large, homogeneously staining chromosome regions which lack the longitudinal differentiation ordinarily revealed by cytogenetic "banding" methods have been found in antifolate-resistant Chinese hamster cells and also in human neuroblastoma cells established in vitro. The drug-resistant cells are characterized by excessive production of the target enzyme, dihydrofolate reductase, while the human neuroblastoma cells have phenotypes of normal neuronal cells. The homogeneously staining region appears to represent a novel metaphase chromosome anomaly which may have functional significance in cells with specialized properties.
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Cited by
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Fenech, M. (2006) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2006.05.028 · Cited by 466
Extrachromosomal circular DNA is common in yeast
Møller, H. D., Parsons, L., Jørgensen, T. S., Botstein, D., & Regenberg, B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508825112 · Cited by 296
Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification
Clarke, T. L., Tang, R., Chakraborty, D., Van Rechem, C., Ji, F., Mishra, S., Ma, A., Kaniskan, H. Ü., Jin, J., Lawrence, M. S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0463 · Cited by 50
HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters
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Metadata
- Authors
- Biedler, J. L., & Spengler, B. A.
- Venue
- Science
- Published
- 1976-01-16
- Volume
- 191
- Issue
- 4223
- Pages
- 185-187
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082749146
- Cited by
- 391
- References
- 0
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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