The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
[D-Ala 2 ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic
Abstract
[D-Ala 2 ]-Met-enkephalinamide (DALA), a synthetic enkephalin analog designed by in vitro analysis, binds to opiate receptors almost as tightly as methionine-enkephalin. Since it is not susceptible to degradation by brain enzymes, low doses (5 to 10 micrograms) cause profound, long-lasting, morphine-like analgesia when microinjected into rat brain.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
D'AMOUR, F. E., & SMITH, D. L. (1941) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03823-6 · Cited by 3,231
Opiate Receptor: Demonstration in Nervous Tissue
Pert, C. B., & Snyder, S. H. (1973) · Science · doi:10.1126/science.179.4077.1011 · Cited by 2,388
Self-citationOpiates and endogenous opioid peptides
Kelly, J. S., & Dingledine, R. (1977) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(77)90262-6 · Cited by 1,282
Stereospecific Binding of the Potent Narcotic Analgesic [ 3 H]Etorphine to Rat-Brain Homogenate
Simon, E. J., Hiller, J. M., & Edelman, I. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.7.1947 · Cited by 1,067
Hughes, J. (1975) · Brain Research · doi:10.1016/0006-8993(75)90391-1 · Cited by 982
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.
Li, C. H., & Chung, D. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1145 · Cited by 637
Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium
PERT, C. B., & SNYDER, S. H. (1974) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14011-x · Cited by 569
Self-citationMode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates
HAMBROOK, J. M., MORGAN, B. A., RANCE, M. J., & SMITH, C. F. C. (1976) · Nature · doi:10.1038/262782a0 · Cited by 519
Properties of Opiate-Receptor Binding in Rat Brain
Pert, C. B., & Snyder, S. H. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2243 · Cited by 438
Self-citation
Cited by
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Opiate analgesics inhibit substance P release from rat trigeminal nucleus
JESSELL, T. M., & IVERSEN, L. L. (1977) · Nature · doi:10.1038/268549a0 · Cited by 965
Dynorphin-(1-13), an extraordinarily potent opioid peptide.
Goldstein, A., Tachibana, S., Lowney, L. I., Hunkapiller, M., & Hood, L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6666 · Cited by 882
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Peptides in the Brain: The New Endocrinology of the Neuron
Guillemin, R. (1978) · Science · doi:10.1126/science.212832 · Cited by 485
Metadata
- Authors
- Pert, C. B., Pert, A., Chang, J.-K., & Fong, B. T.
- Venue
- Science
- Published
- 1976-10-15
- Volume
- 194
- Issue
- 4262
- Pages
- 330-332
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965166997
- Cited by
- 469
- References
- 20
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: [D-Ala 2 ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic. https://app.cochat.ai/papers/10.1126/science.968485
- The paper
- Pert, C. B., Pert, A., Chang, J.-K., & Fong, B. T. (1976). [D-Ala 2 ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic. Science. https://doi.org/10.1126/science.968485
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
