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The Biochemical High-Risk Paradigm: Behavioral and Familial Correlates of Low Platelet Monoamine Oxidase Activity
Abstract
A population of individuals potentially at risk for psychiatric disorders was identified by screening 375 college student volunteers for low platelet monoamine oxidase (MAO) activity levels. The lower and upper 10 percent in MAO activity were interviewed and family history data were obtained. Low-MAO probands reported more frequent psychiatric or psychological counseling and problems with the law. Families of low-MAO probands had an eightfold increase in the incidence of suicide or suicide attempts over those of high-MAO probands. This suggests that reduced MAO levels, reported previously in patients with affective disorders and chronic schizophrenia, may predict a vulnerability to psychiatric disorder.
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Citations
Cited by
Monroe, S. M., & Simons, A. D. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.3.406 · Cited by 2,143
Cognitive event-related potential correlates of schizophrenia.
Pritchard, W. S. (1986) · Psychological Bulletin · doi:10.1037//0033-2909.100.1.43 · Cited by 353
Platelet MAO activity as a biological marker in subgroups of alcoholism
von Knorring, A. ‐., Bohman, M., von Knorring, L., & Oreland, L. (1985) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1985.tb02570.x · Cited by 310
Oreland, L., Wiberg, Å., Åsberg, M., Träskman, L., Sjöstrand, L., Thorén, P., Bertilsson, L., & Tybring, G. (1981) · Psychiatry Research · doi:10.1016/0165-1781(81)90004-4 · Cited by 273
Monoamine oxidase and cigarette smoking
Fowler, J. S., Logan, J., Wang, G.-J., & Volkow, N. D. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(02)00109-2 · Cited by 251
Metadata
- Authors
- Buchsbaum, M. S., Coursey, R. D., & Murphy, D. L.
- Venue
- Science
- Published
- 1976-10-15
- Volume
- 194
- Issue
- 4262
- Pages
- 339-341
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094700723
- Cited by
- 376
- References
- 0
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Buchsbaum, M. S., Coursey, R. D., & Murphy, D. L. (1976). The Biochemical High-Risk Paradigm: Behavioral and Familial Correlates of Low Platelet Monoamine Oxidase Activity. Science. https://doi.org/10.1126/science.968488
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
