Monoamine oxidase and cigarette smoking
Abstract
Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence that this is a pharmacological effect of tobacco smoke exposure rather than a biological characteristic of smokers. This article summarizes human and animal studies documenting the inhibitory effects of tobacco smoke on MAO and discusses MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation.
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Cigarette smoke reduces monoamine oxidase A and B activity, prolonging the synaptic action of neurotransmitters with a role in mood regulation.
“Furthermore, cigarette smoke reduces Monoamine oxidase (MAO) A and B activity (27), prolonging the synaptic action of neurotransmitters with a role in mood regulation (e.g., serotonin and dopamine).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [27]
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- Authors
- Fowler, J. S., Logan, J., Wang, G.-J., & Volkow, N. D.
- Affiliations
- Brookhaven National Laboratory (US)
- Corresponding author
- Fowler, Joanna S.
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 24
- Issue
- 1
- Pages
- 75-82
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W2138349568
- Cited by
- 251
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 29 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 8
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- National Institute on Drug Abuse
- Brookhaven National Laboratory
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- monoamine oxidase, cigarette smoking, tobacco smoke, monoamine oxidase inhibition, tobacco smoke constituents, smoking cessation, mental illness
- MeSH terms
- Animals, Mental Disorders, Brain, Humans, Monoamine Oxidase, Monoamine Oxidase Inhibitors, Smoking, Smoking Cessation
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