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Mass spectrometry imaging with laser-induced postionization
Abstract
Imaging lipid composition: Chemical imaging of cell membranes can be performed with matrix-assisted laser desorption/ionization mass spectrometry (MALDI), but low ionization efficiency often leads to a signal dominated by the main lipid components, such as abundant phosphatidylcholine species. Soltwisch et al. used a tunable laser for post-ionization of neutral species to boost the signal for other membrane components, such as cholesterol and phospho- and glycolipids. Imaging of cells and tissues with these methods allows differentiation based on a more extensive chemical signature. Science , this issue p. 211
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Cited by
Kompauer, M., Heiles, S., & Spengler, B. (2017) · Nature Methods · doi:10.1038/nmeth.4071 · Cited by 600
Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development
Schulz, S., Becker, M., Groseclose, M. R., Schadt, S., & Hopf, C. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.08.003 · Cited by 325
Körber, A., Anthony, I. G. M., & Heeren, R. M. A. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05249 · Cited by 88
Steil, D., Schepers, C.-L., Pohlentz, G., Legros, N., Runde, J., Humpf, H.-U., Karch, H., & Müthing, J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m063040 · Cited by 31
Self-citationNovel methods in adrenal research: a metabolomics approach
Papathomas, T. G., Sun, N., Chortis, V., Taylor, A. E., Arlt, W., Richter, S., Eisenhofer, G., Ruiz-Babot, G., Guasti, L., & Walch, A. K. (2019) · Histochemistry and Cell Biology · doi:10.1007/s00418-019-01772-w · Cited by 14
Metadata
- Authors
- Soltwisch, J., Kettling, H., Vens-Cappell, S., Wiegelmann, M., Müthing, J., & Dreisewerd, K.
- Venue
- Science
- Published
- 2015-04-10
- Volume
- 348
- Issue
- 6231
- Pages
- 211-215
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036847748
- Cited by
- 382
- References
- 0
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
