Novel methods in adrenal research: a metabolomics approach
Abstract
Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning endocrine and endocrine-related disease has significantly expanded over the last decade. Herein, we focus on novel metabolomics-related methodologies in adrenal research: in situ metabolomics by mass spectrometry imaging, steroid metabolomics by gas and liquid chromatography-mass spectrometry, energy pathway metabologenomics by liquid chromatography-mass spectrometry-based metabolomics of Krebs cycle intermediates, and cellular reprogramming to generate functional steroidogenic cells and hence to modulate the steroid metabolome. All four techniques to assess and/or modulate the metabolome in biological systems provide tremendous opportunities to manage neoplastic and non-neoplastic disease of the adrenal glands in the era of precision medicine. In this context, we discuss emerging clinical applications and/or promising metabolic-driven research towards diagnostic, prognostic, predictive and therapeutic biomarkers in tumours arising from the adrenal gland and extra-adrenal paraganglia as well as modern approaches to delineate and reprogram adrenal metabolism.
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Specificity rates of 85% to 89% for metanephrine testing decrease to 77% in elderly people and can be improved by using age-adjusted reference ranges.
“Specificity rates of 85% to 89% decrease to 77% in elderly people and can be improved by using age-adjusted reference ranges (204-206).”
From Adrenal incidentaloma (2020) · cites this paper as [206]
LC-MS/MS is considerably faster and less labor intensive and allows much higher throughput than GC-MS.
“LC-MS/MS is considerably faster and less labor intensive and allows a much higher throughput than GC-MS; however, LC-MS/MS has a poorer resolving capacity (206).”
From Adrenal incidentaloma (2020) · cites this paper as [206]
In mass spectrometry, steroids are identified by unique retention times and/or multiple reaction monitoring, and the area under the peak in the chromatogram is proportional to concentration and quantifiable via comparison to standard reference materials.
“In mass spectrometry, steroids are identified by unique retention times and or multiple reaction monitoring (206) with the area under the peak in the chromatogram is proportional to its concentration and quantifiable via comparison to standard reference materials of known concentration.”
From Adrenal incidentaloma (2020) · cites this paper as [206]
LC-MS/MS is more suited to a smaller panel of corticosteroids and their metabolites and does not have the same broad scope of analysis as GC-MS.
“As a result, LC-MS/MS is more suited to a smaller panel of corticosteroids and their metabolites and as a result does not have the same broad scope of analysis that GC-MS allows (206).”
From Adrenal incidentaloma (2020) · cites this paper as [206]
LC-MS/MS has poorer resolving capacity than GC-MS.
“LC-MS/MS is considerably faster and less labor intensive and allows a much higher throughput than GC-MS; however, LC-MS/MS has a poorer resolving capacity (206).”
From Adrenal incidentaloma (2020) · cites this paper as [206]
Given the preanalytical and analytical advantages of LC-MS/MS over GC-MS, LC-MS/MS is better suited to clinical practice once adequate optimization has been performed.
“Given the preanalytical and analytical advantages of LC-MS/MS over GC-MS, it is better suited to clinical practice once adequate optimization has been performed.”
From Adrenal incidentaloma (2020) · cites this paper as [206]
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Self-citation
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Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“…tumors in terms of improved histopathological techniques that include In situ metabolomics utilizing high-mass resolution matrix-assisted laser desorption/ionization mass spectrometry imaging, which has been extensively reviewed by Papathomas et al. (206) and is beyond the scope of this review.”
BackgroundInfluentialExploring the promising potential of induced pluripotent stem cells in cancer research and therapy
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- Authors
- Papathomas, T. G., Sun, N., Chortis, V., Taylor, A. E., Arlt, W., Richter, S., Eisenhofer, G., Ruiz-Babot, G., Guasti, L., & Walch, A. K.
- Affiliations
- Helmholtz Munich (DE)
- University of Birmingham (GB)
- University Hospital Carl Gustav Carus (DE)
- Queen Mary University of London (GB)
- Corresponding author
- Walch, Axel Karl
- ORCID
- Venue
- Histochemistry and Cell Biology
- Published
- 2019-02-06
- Volume
- 151
- Issue
- 3
- Pages
- 201-216
- ISSN
- 0948-6143 (ISSN-L)
- 1432-119X
- OpenAlex
- W2912874287
- Cited by
- 14
- References
- 137
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Histochemistry and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 824 C4, CRC/Transregio 205/1, CRC/Transregio 205)
- Pathological Society of Great Britain and Ireland (PathSoc 2018 Visiting Fellowship/Grant Reference No: 1183)
- Deutsche Krebshilfe (70112617)
- German Federal Ministry of Education and Research (BMBF, 01ZX1210B, 01KT1615)
- The Paradifference foundation
- Academy of Medical Sciences (Starter Grant for Clinical Lecturers)
- European Commission Horizon 2020 Programme (633893 (ENSAT-HT))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenal gland, adrenal tumors, adrenal paraganglioma, mass spectrometry imaging, Krebs cycle intermediates, cellular reprogramming, steroidogenic cells, metabolic biomarkers, precision medicine
- MeSH terms
- Adrenal Glands, Animals, Chromatography, Liquid, Humans, Mass Spectrometry, Metabolomics
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