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Cited by 539

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Synthesis of many different types of organic small molecules using one automated process

Open access
Li, Junqi, Ballmer, Steven G., Gillis, Eric P., Fujii, Seiko, Schmidt, Michael J., Palazzolo, Andrea M. E., Lehmann, Jonathan W., Morehouse, Greg F., Burke, Martin D.·2015·Science
DOI 10.1126/science.aaa5414
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Abstract

A block-by-block way to manufacture molecules: Carbon-based small molecules involved in biochemistry and drug design exhibit extraordinary structural diversity. But can we come up with a general set of building blocks from which a machine could put most of them together, in assembly-line fashion? Li et al. present progress toward this goal by showcasing the range of structures available via coupling reactions of fragments bearing a specific type of boronate group. They successfully made complex polycyclic structures by stringing together a linear precursor and then coaxing it to fold back on itself. They also developed a purification method that facilitates automation of the reaction and product isolation. Science , this issue p. 1221

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Metadata

Authors
Li, J., Ballmer, S. G., Gillis, E. P., Fujii, S., Schmidt, M. J., Palazzolo, A. M. E., Lehmann, J. W., Morehouse, G. F., & Burke, M. D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2015-03-13
Volume
347
Issue
6227
Pages
1221-1226
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aaa5414
OpenAlex
W1965815220
Cited by
539
References
1
FWCI
22.13
Type
journal article
Language
en
Open access
green
Licence
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Funders
  • NSF (747778)
  • NIH (GM080436, GM090153)
  • HHMI
  • Bristol-Myers Squibb

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CoChat. (2026). Citation check: Synthesis of many different types of organic small molecules using one automated process. https://app.cochat.ai/papers/10.1126/science.aaa5414
The paper
Li, J., Ballmer, S. G., Gillis, E. P., Fujii, S., Schmidt, M. J., Palazzolo, A. M. E., Lehmann, J. W., Morehouse, G. F., & Burke, M. D. (2015). Synthesis of many different types of organic small molecules using one automated process. Science. https://doi.org/10.1126/science.aaa5414

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.