Adult cortical plasticity depends on an early postnatal critical period
Open accessAbstract
Keeping synaptic plasticity plastic: Neuronal synapses in the brain adjust according to shifting demands as we experience the world. This synaptic plasticity forms the basis for critical periods in the visual and somatosensory systems. Greenhill et al. have now found, in mice, a critical period for the development of plasticity itself. At the core is a protein that in its mutant form is associated with schizophrenia. Disrupting this protein's function temporarily during early development caused a failure in brain plasticity in adult mice. Science , this issue p. 424
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Even the most subtle variation in the organization of brain circuits during sensitive time windows contributes to functional alterations that persist throughout life.
“It is therefore conceivable that even the most subtle variation in the organization of brain circuits during these sensitive time windows contributes to functional alterations that persist throughout life, as shown in animal studies 17 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [17]
NAC treatment prevents PVI abnormalities in the NVHL model and blocking superoxide overproduction by NADPH oxidase prevents the PVI impairment induced by social isolation.
“Evidence causally linking oxidative stress to PVI deficits in other schizophrenia models also exists: NAC treatment prevents PVI abnormalities in the NVHL model 56 and blocking superoxide overproduction by NADPH oxidase (NOX) prevents the PVI impairment induced by social isolation 64 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [64]
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Synaptic dysregulation in a human iPS cell model of mental disorders
Wen, Z., Nguyen, H. N., Guo, Z., Lalli, M. A., Wang, X., Su, Y., Kim, N.-S., Yoon, K.-J., Shin, J., Zhang, C., et al. (2014) · Nature · doi:10.1038/nature13716 · Cited by 549 · see citing works
Feldmeyer, D., Egger, V., Lübke, J., & Sakmann, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00169.x · Cited by 441 · see citing works
Wozny, C., & Williams, S. R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq257 · Cited by 129 · see citing works
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Research works printed but not linked: 5
- Soares, D. C. et al. The Journal of biological chemistry 287, 32381-32393, (2012).
- K. Fox, M. Armstrong-James, J. Millar, The electrical characteristics of carbon fibre microelectrodes. Journal of neuroscience methods 3, 37 (Oct, 1980).
- R. N. Strominger, T. A. Woolsey, Templates for locating the whisker area in fresh flattened mouse and rat cortex. Journal of neuroscience methods 22, 113 (Dec, 1987).
- C. W. Bird et al., Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. PloS one 10, e0118721 (2015).
- D. A. Sholl, Dendritic organization in the neurons of the visual and motor cortices of the cat. Journal of anatomy 87, 387 (Oct, 1953).
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Developmental timing and critical windows for the treatment of psychiatric disorders
Marín, O. (2016) · Nature Medicine · doi:10.1038/nm.4225 · Cited by 374 · see citing works
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works
Spindle activity orchestrates plasticity during development and sleep
Lindemann, C., Ahlbeck, J., Bitzenhofer, S. H., & Hanganu-Opatz, I. L. (2016) · Neural Plasticity · doi:10.1155/2016/5787423 · Cited by 59 · see citing works
Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45 · see citing works
Dong, J., Fu, H., Fu, Y., You, M., Li, X., Wang, C., Leng, K., Wang, Y., & Chen, J. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00612 · Cited by 20 · see citing works
- Authors
- Greenhill, S. D., Juczewski, K., de Haan, A. M., Seaton, G., Fox, K., & Hardingham, N. R.
- Affiliations
- Cardiff University (GB)
- National Institutes of Health (US)
- School of Biosciences, Cardiff University, Cardiff, CF23 3AX, UK.
- Corresponding author
- Greenhill, Stuart D.
- Juczewski, Konrad
- Hardingham, Neil R.
- Venue
- Science
- Published
- 2015-07-24
- Volume
- 349
- Issue
- 6246
- Pages
- 424-427
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1825929091
- Cited by
- 76
- References
- 3
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 12 · 2020: 10 · 2019: 7 · 2018: 6 · 2017: 12 · 2016: 14 · 2015: 3
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- Funders
- NIH
- U.S. National Institute of Mental Health
- UK Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- critical period, postnatal development, DISC1, long-term potentiation, long-term depression, synaptic plasticity, schizophrenia, mouse model
- MeSH terms
- Animals, Mental Disorders, Cerebral Cortex, Cognition Disorders, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Synapses, Tamoxifen, Age of Onset, Long-Term Potentiation, Mice
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