Maternal Exposure to Di-(2-ethylhexyl) Phthalate Impairs Hippocampal Synaptic Plasticity in Male Offspring: Involvement of Damage to Dendritic Spine Development

Dose translation from animal to human studies revisited.

Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524 · see citing works

Dendritic spine pathology in neuropsychiatric disorders

Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523 · see citing works

Developmental mechanisms that generate precise patterns of neuronal connectivity

Goodman, C. S., & Shatz, C. J. (1993) · Cell · doi:10.1016/s0092-8674(05)80030-3 · Cited by 1,425 · see citing works

Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity

Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269 · see citing works

Dentritic spines : structure, dynamics and regulation

Hering, H., & Sheng, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35104061 · Cited by 961 · see citing works

Balancing Structure and Function at Hippocampal Dendritic Spines

Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916 · see citing works

Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism

Woolley, C. S., & McEwen, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07680.1994 · Cited by 679 · see citing works

Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies

Arellano, J. I. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.010.2007 · Cited by 529 · see citing works

Structure, development, and plasticity of dendritic spines

Harris, K. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80050-6 · Cited by 515 · see citing works

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

Hall, A. K., & Nobes, C. D. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0632 · Cited by 513 · see citing works

Structural plasticity upon learning: regulation and functions

Caroni, P., Donato, F., & Muller, D. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3258 · Cited by 491 · see citing works

Leaching of the plasticizer di(2-ethylhexyl)phthalate (DEHP) from plastic containers and the question of human exposure

Erythropel, H. C., Marić, M., Nicell, J. A., Leask, R. L., & Yargeau, V. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-6183-8 · Cited by 471 · see citing works

Rapid turnover of actin in dendritic spines and its regulation by activity

Star, E. N., Kwiatkowski, D. J., & Murthy, V. N. (2002) · Nature Neuroscience · doi:10.1038/nn811 · Cited by 465 · see citing works

Synapses and Alzheimer's Disease

Sheng, M., Sabatini, B. L., & Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005777 · Cited by 436 · see citing works

Structural plasticity of dendritic spines

Bosch, M., & Hayashi, Y. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.002 · Cited by 415 · see citing works

Reproductive and developmental effects of phthalate diesters in females

Kay, V. R., Chambers, C., & Foster, W. G. (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.766149 · Cited by 397 · see citing works

Structural Components of Synaptic Plasticity and Memory ConsolidationPreprint

Bailey, C. H., Kandel, E. R., & Harris, K. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021758 · Cited by 393 · see citing works

Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration

Stankiewicz, T. R., & Linseman, D. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00314 · Cited by 391 · see citing works

Rho GTPases, dendritic structure, and mental retardation

Newey, S. E., Velamoor, V., Govek, E., & Van Aelst, L. (2005) · Journal of Neurobiology · doi:10.1002/neu.20153 · Cited by 351 · see citing works

Role of actin cytoskeleton in dendritic spine morphogenesis

Sekino, Y., Kojima, N., & Shirao, T. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.029 · Cited by 294 · see citing works

The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons

Zagrebelsky, M., Holz, A., Dechant, G., Barde, Y.-A., Bonhoeffer, T., & Korte, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2492-05.2005 · Cited by 286 · see citing works

Development and Regulation of Dendritic Spine Synapses

Calabrese, B., Wilson, M. S., & Halpain, S. (2006) · Physiology · doi:10.1152/physiol.00042.2005 · Cited by 267 · see citing works

Dendritic spines: Revisiting the physiological role

Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., Manivasagam, T., Thenmozhi, A. J., Essa, M. M., Guillemin, G. J., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.005 · Cited by 255 · see citing works

Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome

Galvez, R., & Greenough, W. T. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30709 · Cited by 231 · see citing works

Molecular anatomy of the postsynaptic density.

Okabe, S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.006 · Cited by 225 · see citing works

Dendritic spine alterations in schizophrenia

Moyer, C. E., Shelton, M. A., & Sweet, R. A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.11.042 · Cited by 184 · see citing works

Electrical compartmentalization in dendritic spines

Yuste, R. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150455 · Cited by 180 · see citing works

Internetwork competition for monomers governs actin cytoskeleton organization

Suarez, C., & Kovar, D. R. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.106 · Cited by 164 · see citing works

Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age

Téllez‐Rojo, M. M., Cantoral, A., Cantonwine, D. E., Schnaas, L., Peterson, K. E., Hu, H., & Meeker, J. D. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.05.021 · Cited by 163 · see citing works

Developmental neurotoxicity of ortho-phthalate diesters: Review of human and experimental evidence

Miodovnik, A., Edwards, A., Bellinger, D. C., & Hauser, R. B. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.01.007 · Cited by 162 · see citing works

Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6–15 years

Chopra, V., Harley, K. G., Lahiff, M., & Eskenazi, B. (2013) · Environmental Research · doi:10.1016/j.envres.2013.10.004 · Cited by 139 · see citing works

Fetal origin of endocrine dysfunction in the adult: The phthalate model

Martinez-Arguelles, D. B., Campioli, E., Culty, M., Zirkin, B. R., & Papadopoulos, V. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.01.007 · Cited by 130 · see citing works

Perinatal exposure to di-(2-ethylhexyl) phthalate affects anxiety- and depression-like behaviors in mice

Xu, X., Yang, Y., Wang, R., Wang, Y., Ruan, Q., & Yang, L. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.10.056 · Cited by 124 · see citing works

Prenatal exposure to phthalates and neuropsychological development during childhood

Gascón, M., Valvi, D., Forns, J., Casas, M., Martinez, D. R., Júlvez, J., Monfort, N., Ventura, R., Sunyer, J., & Vrijheid, M. (2015) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2015.05.006 · Cited by 107 · see citing works

Prenatal Exposure to DEHP Induces Neuronal Degeneration and Neurobehavioral Abnormalities in Adult Male Mice

Barakat, R., Lin, P.-C. P., Park, C. J., Best-Popescu, C. A., Bakry, H. H., AboSalem, M., Abdelaleem, N. M., Flaws, J. A., & Ko, C. J. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy103 · Cited by 105 · see citing works

Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain

Rebuli, M. E., & Patisaul, H. B. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.08.021 · Cited by 104 · see citing works

Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens

Zhou, F., Anthony, B., Dunn, K. W., Lindquist, W. B., Xu, Z. C., & Deng, P. (2007) · Brain Research · doi:10.1016/j.brainres.2006.11.046 · Cited by 102 · see citing works

Multiple cellular cascades participate in long-term potentiation and in hippocampus-dependent learning

Baudry, M., Zhu, G., Liu, Y., Wang, Y., Briz, V., & Bi, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.033 · Cited by 100 · see citing works

Phthalates and neurotoxic effects on hippocampal network plasticity

Holahan, M. R., & Smith, C. A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.02.008 · Cited by 85 · see citing works

Pathogenesis of Abeta Oligomers in Synaptic Failure

Sivanesan, S., Tan, A., & Rajadas, J. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310030011 · Cited by 84 · see citing works

Effects of uterine and lactational exposure to di-(2-ethylhexyl) phthalate on spatial memory and NMDA receptor of hippocampus in mice

Dai, Y., Yang, Y., Xu, X., & Hu, Y. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.03.008 · Cited by 81 · see citing works

Adult cortical plasticity depends on an early postnatal critical period

Greenhill, S. D., Juczewski, K., de Haan, A. M., Seaton, G., Fox, K., & Hardingham, N. R. (2015) · Science · doi:10.1126/science.aaa8481 · Cited by 76 · see citing works

New insights on synaptic dysfunction in neuropsychiatric disorders

Caldeira, G. L., Peça, J., & Carvalho, A. L. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.01.004 · Cited by 76 · see citing works

Phthalate metabolites in Norwegian mothers and children: Levels, diurnal variation and use of personal care products

Sakhi, A. K., Sabaredzovic, A., Cequier, E., & Thomsen, C. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.05.109 · Cited by 74 · see citing works

Circulating phthalates during critical illness in children are associated with long-term attention deficit: a study of a development and a validation cohort

Verstraete, S., Vanhorebeek, I., Covaci, A., Güiza, F., Malarvannan, G., Jorens, P. G., & den Berghe, G. V. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-4159-5 · Cited by 72 · see citing works

Learning and reconsolidation implicate different synaptic mechanisms

Li, Y., Meloni, E. G., Carlezon, W. A., Milad, M. R., Pitman, R. K., Nader, K., & Bolshakov, V. Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217878110 · Cited by 61 · see citing works

Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation

de Arce, K. P., Varela‐Nallar, L., Farias, O., Cifuentes, A., Bull, P., Couch, B. A., Koleske, A. J., Inestrosa, N. C., & Alvarez, A. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2024-09.2010 · Cited by 59 · see citing works

Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring

Dong, J., Cong, Z., You, M., et al. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2019.01.012 · Cited by 53 · see citing works

Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice

Pan, W., Han, S., Kang, L., Li, S., Du, J., & Cui, H. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3470 · Cited by 49 · see citing works

Perinatal exposure to di‐(2‐ethylhexyl)‐phthalate leads to cognitive dysfunction and phospho‐tau level increase in aged rats

Sun, W., Ban, J., Zhang, N., Zu, Y., & Sun, W. (2012) · Environmental Toxicology · doi:10.1002/tox.21785 · Cited by 46 · see citing works

Migration of plasticizers from PVC medical devices: Development of an infusion model.

Bernard, L., Cueff, R., Chagnon, M., et al. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.08.033 · Cited by 43 · see citing works

Effects of maternal exposure to di(2-ethylhexyl)phthalate (DEHP) during pregnancy on susceptibility to neonatal asthma

Shin, I., Lee, M.-Y., Cho, E.-S., Choi, E.-Y., Son, H., & Lee, K. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.12.009 · Cited by 42 · see citing works

Exposure to Di-(2-ethylhexyl) Phthalate During Perinatal Period Gender-Specifically Impairs the Dendritic Growth of Pyramidal Neurons in Rat Offspring

You, M., Dong, J., Fu, Y., Cong, Z., Fu, H., Wei, L., Wang, Y., Wang, Y., & Chen, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00444 · Cited by 39 · see citing works

The roles of hippocampal microRNAs in response to acute postnatal exposure to di(2-ethylhexyl) phthalate in female and male rats

Luu, B. E., Green, S. R., Childers, C. L., Holahan, M. R., & Storey, K. B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.02.004 · Cited by 32 · see citing works

Effects of high-speed railway noise on the synaptic ultrastructure and phosphorylated-CaMKII expression in the central nervous system of SD rats

Di, G., & Zheng, Y. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.11.012 · Cited by 28 · see citing works

Actin polymerization is reduced in the anterior cingulate cortex of elderly patients with schizophrenia

Bhambhvani, H. P., Mueller, T., Simmons, M. S., & Meador‐Woodruff, J. H. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0045-y · Cited by 28 · see citing works

Maternal di-(2-ethylhexyl) phthalate exposure inhibits cerebellar granule precursor cell proliferation via down-regulating the Shh signaling pathway in male offspring

Fu, Y., Dong, J., You, M., Cong, Z., Wei, L., Fu, H., Wang, Y., Wang, Y., & Chen, J. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.10.040 · Cited by 26 · see citing works

Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway

Fu, Y., Dong, J., Wang, J., You, M., Wei, L., Fu, H., Wang, Y., & Chen, J. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.6.472 · Cited by 25 · see citing works

Differentiation and neural integration of hippocampal neuronal progenitors: Signaling pathways sequentially involved

Akchiche, N., Bossenmeyer‐Pourié, C., Pourié, G., et al. (2009) · Hippocampus · doi:10.1002/hipo.20690 · Cited by 18 · see citing works

Effects of synaptic plasticity regulated by 17β-estradiol on learning and memory in rats with Alzheimer’s disease

Shang, X., Zhao, J., Cao, Y., & Xue, Y. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-0913-4 · Cited by 14 · see citing works

Dendritic spine loss caused by AlCl3 is associated with inhibition of the Rac 1/cofilin signaling pathway

Yang, X., Cao, Z., Zhang, J., Shao, B., Song, M., Han, Y., & Li, Y. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.145 · Cited by 13 · see citing works

Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton

Min, H., Dong, J., Wang, Y., Wang, Y., Yu, Y., Shan, Z., Xi, Q., Teng, W., & Chen, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9657-5 · Cited by 12 · see citing works

Conditioned Place Preference Associated with Level of Palmitoylation of PSD-95 in Rat Hippocampus and Nucleus Accumbens

Zhang, X., Liu, X., Wang, D., Liu, H., & Hao, W. (2011) · Neuropsychobiology · doi:10.1159/000327603 · Cited by 10 · see citing works

More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines

Schlett, K. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201705216 · Cited by 6 · see citing works

Dendritic spine loss caused by AlCl3 is associated with inhibition of the Rac 1/cofilin signaling pathway

Yang, X., Cao, Z., Zhang, J., Shao, B., Song, M., Han, Y., & Li, Y. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.145 · Cited by 13 · see citing works

Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

Shi, Y., Pontrello, C. G., DeFea, K., Reichardt, L. F., & Ethell, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4681-08.2009 · Cited by 166 · see citing works

The Regulation of Dendritic Spine Plasticity by EphB and N-methyl-D-aspartate Receptors Through Spatial Control Over Cofilin Activity in Mature Hippocampal Neurons

Pontrello, C. G. (2010) · eScholarship (California Digital Library)

Automated spatio-temporal analysis of dendritic spines and related protein dynamics

On, V., Zahedi, A., Ethell, I. M., & Bhanu, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182958 · Cited by 7 · see citing works

Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines

Pontrello, C. G., & Ethell, I. M. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903020067 · Cited by 43 · see citing works