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Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

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Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes

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Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer’s disease

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A Postgenomic Perspective on Molecular Cytogenetics

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Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortexPreprint

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Advances in single-cell DNA sequencing enable insights into human somatic mosaicism

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Quantification of somatic mutation flow across individual cell division events by lineage sequencingPreprint

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Targeted re-sequencing approach of candidate genes implicates rare potentially functional variants in Tourette Syndrome etiology

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Somatic mutation that affects transcription factor binding upstream of CD55 in the temporal cortex of a late-onset Alzheimer disease patient

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Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

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Cell Lineage Tracing and Cellular Diversity in Humans

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Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers

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Genetic Mosaicism and Cancer: Cause and Effect

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Brain endocannabinoid signaling exhibits remarkable complexity

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Advances in the genetic classification of amyotrophic lateral sclerosis

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Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data

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Constructing cell lineages from single-cell transcriptomes

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Methods and applications of genome-wide profiling of DNA damage and rare mutations

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Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system

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Histone H2A Ubiquitination Resulting From Brap Loss of Function Connects Multiple Aging Hallmarks and Accelerates Neurodegeneration

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Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies

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Cellular identity at the single-cell level

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Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites

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Illegitimate and Repeated Genomic Integration of Cell-Free Chromatin in the Aetiology of Somatic Mosaicism, Ageing, Chronic Diseases and Cancer

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SomaticTARDBPvariants as a cause of semantic dementia

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The NIH NeuroBioBank: creating opportunities for human brain research

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Somatic variants in epilepsy – advancing gene discovery and disease mechanisms

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Somatic Mosaicism in Biology and Disease

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Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture

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Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia

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MIPP-Seq: ultra-sensitive rapid detection and validation of low-frequency mosaic mutations

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Single-genome sequencing reveals within-host evolution of human malaria parasites

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Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo

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Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples

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Behavioral Variability and Somatic Mosaicism: A Cytogenomic Hypothesis

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Single-cell damagenome profiling unveils vulnerable genes and functional pathways in human genome toward DNA damage

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Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives

Ganguly, P., Toghill, B. J., & Pathak, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212225 · Cited by 17

Haplotype phasing in single-cell DNA-sequencing data

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SCCNV: A Software Tool for Identifying Copy Number Variation From Single-Cell Whole-Genome Sequencing

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Beyond genome‐wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder

Salvatore, J. E., Han, S., Farris, S. P., Mignogna, K. M., Miles, M. F., & Arpana Agrawal, A. (2018) · Addiction Biology · doi:10.1111/adb.12591 · Cited by 18

Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking

Lareau, C. A., Ludwig, L. S., & Sankaran, V. G. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019001196 · Cited by 17

Single-cell omics sequencing technologies: the long-read generation

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Structural diverseness of neurons between brain areas and between cases

Mizutani, R., Saiga, R., Yamamoto, Y., Uesugi, M., Takeuchi, A., Uesugi, K., Terada, Y., Suzuki, Y., Andrade, V. D., Carlo, F. D., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01173-x · Cited by 17

The transcriptional legacy of developmental stochasticity

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Quo vadis: tracing the fate of neural crest cells

Zurkirchen, L., & Sommer, L. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.07.001 · Cited by 17

DSMNC: a database of somatic mutations in normal cells

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A characterization of postzygotic mutations identified in monozygotic twins

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Estimating tumor mutational burden from RNA-sequencing without a matched-normal sample

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The human brain through the lens of somatic mosaicism

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PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation

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Somatic mosaicism: implications for the cardiovascular system

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LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis

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Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes

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DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

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Healthy skeletal muscle aging: The role of satellite cells, somatic mutations and exercise

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Ultraspecific somatic SNV and indel detection in single neurons using primary template-directed amplificationPreprint

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Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder

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Science AMA Series: We are Mollie Woodworth and Michael Lodato (Harvard). We sequenced single neurons from normal human brain and found ~1700 mutations per neuron. We’re here to talk about these “somatPreprint

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