The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
Open accessAbstract
Inflammasomes take the wheel: Cells require microbial ligand binding to sense pathogens (see the Perspective by Liu and Xiao). Binding to the family of NOD-like receptors triggers the assembly of large protein signaling complexes called inflammasomes, leading infected cells to die and produce inflammatory mediators. Hu et al. and Zhang et al. use cryo–electron microscopy to uncover the structural and biochemical basis of two such receptors: NAIP2, which directly binds microbial ligands, and NLRC4, a protein functioning directly downstream. A self-propagating activation mechanism of downstream inflammasome signaling starts with one molecule of NAIP4 directly binding its microbial ligand. NAIP4 then catalyzes the activation of 10 to 12 NLRC4 molecules to form a wheel-like structure. Science , this issue p. 399 , 404 ; see also p. 376
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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
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Sharif, H., Wang, L., Wang, W. L., Magupalli, V. G., Andreeva, L., Qiao, Q., Hauenstein, A. V., Wu, Z., Núñez, G., Mao, Y., et al. (2019) · Nature · doi:10.1038/s41586-019-1295-z · Cited by 824
Self-citationA 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
Barnett, K. C., Li, S., Liang, K., & Ting, J. P.-Y. (2023) · Cell · doi:10.1016/j.cell.2023.04.025 · Cited by 458
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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Freeman, L., Guo, H., David, C. N., Brickey, W. J., Jha, S., & Ting, J. P.-Y. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20150237 · Cited by 397
ASC filament formation serves as a signal amplification mechanism for inflammasomes
Dick, M. S., Sborgi, L., Rühl, S., Hiller, S., & Broz, P. (2016) · Nature Communications · doi:10.1038/ncomms11929 · Cited by 394
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
Andreeva, L., David, L., Rawson, S., Shen, C., Pasricha, T., Pelegrin, P., & Wu, H. (2021) · Cell · doi:10.1016/j.cell.2021.11.011 · Cited by 292
Self-citationKay, C., Wang, R., Kirkby, M., & Man, S. M. (2020) · Immunological Reviews · doi:10.1111/imr.12906 · Cited by 97
Structural basis for flagellin-induced NAIP5 activation
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Metadata
- Authors
- Zhang, L., Chen, S., Ruan, J., Wu, J., Tong, A. B., Yin, Q., Li, Y., David, L., Lu, A., Wang, W. L., Marks, C., Ouyang, Q., Zhang, X., Mao, Y., & Wu, H.
- Venue
- Science
- Published
- 2015-10-23
- Volume
- 350
- Issue
- 6259
- Pages
- 404-409
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168120687
- Cited by
- 403
- References
- 4
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
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