Inflammasomes: mechanism of assembly, regulation and signalling
Abstract
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders. In this Review, we discuss the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammasome assembly, signalling and regulation.
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Caspase-1 initiates the secretion of the pro-inflammatory cytokines IL-1β and IL-18.
“Finally, the main effector caspase, caspase-1, initiates the secretion of the pro-inflammatory cytokines IL-1β and IL-18 [19, 54, 56].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [54]
Inflammasomes are part of the innate immune system that coordinate host defense response against pathogens and host-derived danger signals that communicate cellular stress or toxicity.
“Inflammasomes are a part of the innate immune system that coordinate host defense response against pathogens and host-derived “danger” signals that communicate cellular stress or toxicity [19, 54, 55].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [54]
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- Authors
- Broz, P., & Dixit, V. M.
- Affiliations
- Genentech (US)
- Corresponding author
- Dixit, Vishva M.
- ORCID
- Dixit, Vishva M.
- Venue
- Nature Reviews Immunology
- Published
- 2016-06-13
- Volume
- 16
- Issue
- 7
- Pages
- 407-420
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2431987552
- Cited by
- 3,500
- References
- 16
- Citations by year
- 2026: 336 · 2025: 390 · 2024: 440 · 2023: 498 · 2022: 498 · 2021: 423 · 2020: 366 · 2019: 221 · 2018: 168 · 2017: 127 · 2016: 24 · 2015: 2
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- inflammasome, inflammasome assembly, pattern recognition receptors, inflammatory caspases, pyroptosis, cytokine production, inflammatory diseases, inflammasome regulation
- MeSH terms
- Animals, Humans, Signal Transduction, Inflammasomes
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