The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Complete biosynthesis of opioids in yeast
Open accessAbstract
Toward opioids without poppy fields: Producing opioids without having to depend on field-grown poppies would be of great benefit. Synthetic production could potentially produce more-effective drugs with fewer side effects. Now, Galanie et al. have engineered yeast to produce the opioid compounds thebaine and hydrocodone, starting from sugar (see the Perspective by Nielsen). The amounts produced so far are tiny compared with what would be needed commercially. Future optimization and scaleup are the next challenge. Science , this issue p. 1095 ; see also p. 1050
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Cites
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
Paddon, C. J., & Keasling, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3240 · Cited by 675
Cited by
Engineering Cellular Metabolism
Nielsen, J., & Keasling, J. D. (2016) · Cell · doi:10.1016/j.cell.2016.02.004 · Cited by 1,378
Sugar Synthesis from CO2 in Escherichia coli
Antonovsky, N., Gleizer, S., Noor, E., Zohar, Y., Herz, E., Barenholz, U., Zelcbuch, L., Amram, S., Wides, A., Tepper, N., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.064 · Cited by 365
The opium poppy genome and morphinan production
Guo, L., Winzer, T., Yang, X., Li, Y., Ning, Z., He, Z., Teodor, R., Lu, Y., Bowser, T. A., Graham, I. A., et al. (2018) · Science · doi:10.1126/science.aat4096 · Cited by 341
Tyrosine biosynthesis, metabolism, and catabolism in plants
Schenck, C. A., & Maeda, H. A. (2018) · Phytochemistry · doi:10.1016/j.phytochem.2018.02.003 · Cited by 286
Nielsen, J. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044757 · Cited by 252
Metadata
- Authors
- Galanie, S., Thodey, K., Trenchard, I. J., Filsinger Interrante, M., & Smolke, C. D.
- Venue
- Science
- Published
- 2015-09-04
- Volume
- 349
- Issue
- 6252
- Pages
- 1095-1100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2166323054
- Cited by
- 985
- References
- 2
- FWCI
- 35.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Galanie, S., Thodey, K., Trenchard, I. J., Filsinger Interrante, M., & Smolke, C. D. (2015). Complete biosynthesis of opioids in yeast. Science. https://doi.org/10.1126/science.aac9373
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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