The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Concise total synthesis of glucosepane
Abstract
Getting a handle on a cross-linking motif: Although protein backbones consist exclusively of amino acids, various other molecules in the cell often get latched on afterward in a process termed posttranslational modification. In one such motif, called glucosepane, the side chains of lysine and arginine form a condensed cross-link through a reaction sequence with glucose. Formation of this cross-link is of interest in diabetes research. Draghici et al. now report a chemical synthesis of glucosepane outside the broader environment of a surrounding protein (see the Perspective by Boger). This synthesis should facilitate more precise characterization of the structure and function of the motif in vivo. Science , this issue p. 294 ; see also p. 275
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Welsh, K. J., Kirkman, M. S., & Sacks, D. B. (2016) · Diabetes Care · doi:10.2337/dc15-2727 · Cited by 212
Brings, S., Fleming, T. H., Freichel, M., Muckenthaler, M. U., Herzig, S., & Nawroth, P. P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050984 · Cited by 211
DNA methylation-based age clocks: From age prediction to age reversion
Noroozi, R., Ghafouri‐Fard, S., Pisarek, A., Rudnicka, J., Spólnicka, M., Branicki, W., Taheri, M. N., & Pośpiech, E. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101314 · Cited by 171
Zhu, C., Feng, J., & Zhang, J. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201609608 · Cited by 111
Metadata
- Authors
- Draghici, C., Wang, T., & Spiegel, D. A.
- Affiliations
- Yale University (US)
- Corresponding author
- Spiegel, David A.
- Venue
- Science
- Published
- 2015-10-16
- Volume
- 350
- Issue
- 6258
- Pages
- 294-298
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2279983270
- Cited by
- 46
- References
- 28
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- SENS Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Reactions of Organic Compounds
- Keywords
- glucosepane, total synthesis, protein posttranslational modification, one-pot synthesis, asymmetric synthesis, convergent synthesis, heterocyclic chemistry, diabetes mellitus, aging
- MeSH terms
- Amino Acids, Glucose, Humans, Imidazoles, Protein Processing, Post-Translational, Proteins, Glycation End Products, Advanced
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- Draghici, C., Wang, T., & Spiegel, D. A. (2015). Concise total synthesis of glucosepane. Science. https://doi.org/10.1126/science.aac9655
