The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
Open accessAbstract
Another micropeptide flexes its muscle: Genome annotation is a complex but imperfect art. Attesting to its limitations is the growing evidence that certain transcripts annotated as long noncoding RNAs (lncRNAs) in fact code for small peptides with biologically important functions. One such lncRNA-derived micropeptide in mammals is myoregulin, which reduces muscle performance by inhibiting the activity of a key calcium pump. Nelson et al. describe the opposite activity in a second lncRNA-derived micropeptide in mammalian muscle, called DWORF (see the Perspective by Payre and Desplan). This peptide enhances muscle performance by activating the same calcium pump. DWORF may prove to be useful in improving the cardiac muscle function of mammals with heart disease. Science , this issue p. 271 ; see also p. 226
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LNCcation: lncRNA localization and function
Bridges, M. C., Daulagala, A. C., & Kourtidis, A. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202009045 · Cited by 1,556
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Towards a complete map of the human long non-coding RNA transcriptome
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Exercise Metabolism and Adaptation in Skeletal Muscle
Smith, J. A. B., Murach, K. A., Dyar, K. A., & Zierath, J. R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00606-x · Cited by 342
Metadata
- Authors
- Nelson, B. R., Makarewich, C. A., Anderson, D. M., Winders, B. R., Troupes, C. D., Wu, F., Reese, A. L., McAnally, J. R., Chen, X., Kavalali, E. T., Cannon, S. C., Houser, S. R., Bassel-Duby, R., & Olson, E. N.
- Venue
- Science
- Published
- 2016-01-15
- Volume
- 351
- Issue
- 6270
- Pages
- 271-275
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2237493771
- Cited by
- 788
- References
- 37
- FWCI
- 71.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Nelson, B. R., Makarewich, C. A., Anderson, D. M., Winders, B. R., Troupes, C. D., Wu, F., Reese, A. L., McAnally, J. R., Chen, X., Kavalali, E. T., Cannon, S. C., Houser, S. R., Bassel-Duby, R., & Olson, E. N. (2016). A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science. https://doi.org/10.1126/science.aad4076
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