Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha +36 more·2016·Science
Cited by (623)
Items 201–300 of 623
- MTAP-deficiency could predict better treatment response in advanced lung adenocarcinoma patients initially treated with pemetrexed-platinum chemotherapy and bevacizumabJing Wang, Hui Zhu, Wenjuan Liu, Xiaoyang Zhai, Hairong Tian, Jinming Yu · 2020 · Scientific Reports
- Hallmarks of Splicing Defects in Cancer: Clinical Applications in the Era of Personalized MedicineMohammad Alinoor Rahman, Farhana Nasrin, Sonali Bhattacharjee, Saikat Nandi · 2020 · Cancers
- Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in GlioblastomaBárbara Paranhos Coelho, Camila Felix de Lima Fernandes, Jacqueline Marcia Boccacino, Maria Clara da Silva Souza, Maria Isabel Melo-Escobar, Rodrigo Nunes Alves, Mariana Brandão Prado, Rebeca Piatniczka Iglesia, Giovanni Cangiano, Giulia La Rocca Mazzaro et al. · 2020 · Frontiers in Oncology
- Characterization of Tumor-Suppressor Gene Inactivation Events in 33 Cancer TypesPeilin Jia, Zhongming Zhao · 2019 · Cell Reports
- Early Clinical Success of MTA-Cooperative PRMT5 Inhibitors for the Treatment of CDKN2A/MTAP -Deleted CancersKathleen M. Mulvaney · 2023 · Cancer Discovery
- Synthetic lethality: a step forward for personalized medicine in cancerHeena Jariyal, Frank D. Weinberg, Abhinav Achreja, Deepak Nagarath, Akshay Srivastava · 2019 · Drug Discovery Today
- Testing for BAP1 loss and CDKN2A/p16 homozygous deletion improves the accurate diagnosis of mesothelial proliferations in effusion cytologyMartin Chevrier, Sara E. Monaco, Jacob A. Jerome, Françoise Galateau-Sallé, Andrew Churg, Sanja Đačić · 2020 · Cancer Cytopathology
- PRMT5: An Emerging Target for Pancreatic AdenocarcinomaMichael K.C. Lee, Sean Michael Grimmond, Grant A. McArthur, Karen E. Sheppard · 2021 · Cancers
- Targeting the methionine addiction of cancer.Joni C Sedillo, Vincent L. Cryns · 2022 · PubMed Central
- PRMT5 supports multiple oncogenic pathways in mantle cell lymphomaShelby L. Sloan, Fiona Brown-Burke, Mackenzie Long, Christoph Weigel, Shirsha Koirala, Ji-Hyun Chung, Betsy A. Pray, Lynda Villagomez, Claire Hinterschied, Anuvrat Sircar et al. · 2023 · Blood
- MTAP deficiency contributes to immune landscape remodelling and tumour evasionWen‐Hsin Chang, Ssu‐Wei Hsu, Jun Zhang, Ji‐Min Li, David C.H. Yang, Chih‐Wei Chu, Estelle Heerim Yoo, Weici Zhang, Sung‐Liang Yu, Ching‐Hsien Chen · 2022 · Immunology
- Functions and mechanisms of non-histone post-translational modifications in cancer progressionZongyang Li, Tao Zhu, Yushu Wu, Yongbo Yu, Yun-jiang Zang, Lebo Yu, Zhilei Zhang · 2025 · Cell Death Discovery
- M-TAP Dance: Targeting PRMT1 and PRMT5 Family Members to Push Cancer Cells Over the EdgeNivine Srour, Sofiane Yacine Mersaoui, Stéphane Richard · 2019 · Cancer Cell
- Loss of CDKN2A at chromosome 9 has a poor clinical prognosis and promotes lung cancer progressionWei Liu, Congwen Zhuang, Tengfei Huang, Shengsheng Yang, Meiqing Zhang, Baoquan Lin, Yiguo Jiang · 2020 · Molecular Genetics & Genomic Medicine
- Personalizing Medicine With Germline and Somatic Sequencing in Advanced Pancreatic Cancer: Current Treatments and Novel OpportunitiesMichael S. Lee, Shubham Pant · 2021 · American Society of Clinical Oncology Educational Book
- Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformationZachary A. Hing, Janek S. Walker, Ethan C. Whipp, Lindsey T. Brinton, Matthew J. Cannon, Pu Zhang, Steven Sher, Casey B. Cempre, Fiona Brown-Burke, Porsha L. Smith et al. · 2023 · Nature Communications
- Comparison of Immunohistochemistry, Next-generation Sequencing and Fluorescence In Situ Hybridization for Detection of MTAP Loss in Pleural MesotheliomaChristopher A. Febres‐Aldana, Jason C. Chang, Achim A. Jungbluth, Prasad S. Adusumilli, Francis M. Bodd, Denise Frosina, Jerica A. Geronimo, Enmily Hernandez, Helen Irawan, Michael David Offin et al. · 2024 · Modern Pathology
- The biological essence of synthetic lethality: Bringing new opportunities for cancer therapyMeiyi Ge, Jian Luo, Yi Wu, Guobo Shen, Xi Kuang · 2024 · MedComm – Oncology
- Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discoveryShuai‐Jiang Liu, Qian Zhao, Xiaochen Liu, Allan B. Gamble, Wei Huang, Qian‐Qian Yang, Bo Han · 2024 · Medicinal Research Reviews
- Recent Progress in DNA Damage Response-Targeting PROTAC DegradersBinbin Cheng, Xiaoting Fei, Zongbao Ding, Xiaopeng Peng, Zhenhong Su, Wei Pan, Jianjun Chen · 2024 · Journal of Medicinal Chemistry
- Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA CooperativityJames M. Smith, Bernard C. Barlaam, David Beattie, Lauren Bradshaw, Ho Man Chan, Elisabetta Chiarparin, Olga Collingwood, Sophie L. Cooke, Anna S. Cronin, Iain A. Cumming et al. · 2024 · Journal of Medicinal Chemistry
- MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumorsSi Chen, Jiakai Hou, Roshni Jaffery, Ashley M. Guerrero, Rongjie Fu, Leilei Shi, Ningbo Zheng, Ritu Bohat, Nicholas A. Egan, Cheng‐Tai Yu et al. · 2024 · Journal for ImmunoTherapy of Cancer
- Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP -Deleted CancersLiping H. Pettus, Matthew P. Bourbeau, Nuria A. Tamayo, Albert K. Amegadzie, Diane Beylkin, Shon K. Booker, John Butler, Michael J. Frohn, Matthew R. Kaller, Todd J. Kohn et al. · 2025 · Journal of Medicinal Chemistry
- Generating Stable Knockout Zebrafish Lines by Deleting Large Chromosomal Fragments Using Multiple gRNAsBrian H Kim, Guangjun Zhang · 2020 · G3 Genes Genomes Genetics
- Cancer synthetic vulnerabilities to protein arginine methyltransferase inhibitorsErnesto Guccione, Megan Catherine Schwarz, Federico Di Tullio, Slim Mzoughi · 2021 · Current Opinion in Pharmacology
- Dynamic Interplay between Structural Variations and 3D Genome Organization in Pancreatic CancerYong-Xing Du, Zong-Ting Gu, Zong-Ze Li, Zan Yuan, Yue Zhao, Xiao-Hao Zheng, Xiao-Chen Bo, He-Bing Chen, Cheng-Feng Wang · 2022 · Advancement of science
- Cancer epigenetic therapy: recent advances, challenges, and emerging opportunitiesRajita J. Vatapalli, Alex P. Rossi, Ho Man Chan, Jingwen Zhang · 2024 · Epigenomics
- Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluationsKongkai Zhu, Hongrui Tao, Jiali Song, Jin Lu, Yuanyuan Zhang, Jingqiu Liu, Zhifeng Chen, Cheng‐Shi Jiang, Cheng Luo, Hua Zhang · 2018 · Bioorganic Chemistry
- Downregulation of MTAP promotes Tumor Growth and Metastasis by regulating ODC Activity in Breast CancerYing Zhang, Tiantian Zhang, Lin Gao, Yanan Tan, Yuting Li, Xiangyu Tan, Tuxiong Huang, Huahui Li, Feng Bai, Chang Zou et al. · 2022 · International Journal of Biological Sciences
- Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunitiesShinsuke Araki, Momoko Ohori, Masato Yugami · 2023 · Frontiers in Oncology
- Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and DiseaseNabil Rabhi, Sarah Anissa Hannou, Philippe Froguel, Jean‐Sébastien Annicotte · 2017 · Frontiers in Endocrinology
- Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) InhibitorAlessandra Feoli, Giulia Iannelli, Alessandra Cipriano, Ciro Milite, Lei Shen, Zhihao Wang, Andrea Hadjikyriacou, Troy L. Lowe, Cyrus Safaeipour, Monica Viviano et al. · 2023 · Journal of Medicinal Chemistry
- A review of the known MTA-cooperative PRMT5 inhibitorsMei Long Hu, Xiang Chen · 2024 · RSC Advances
- SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cellsXiaotian Wang, Yongsheng Song, Yaxing Shi, Da Cheng Yang, Jiaxing Li, Bo Yin · 2022 · Cellular & Molecular Biology Letters
- Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 InhibitorsUpendra A. Argikar, Markus Blatter, Dallas Bednarczyk, Zhuoliang Chen, Young Shin Cho, Michaël Doré, Jennifer L. Dumouchel, Samuel B. Ho, Klemens Hoegenauer, Toshio Kawanami et al. · 2022 · Journal of Medicinal Chemistry
- Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancerXiao Li, Fei Li, Fei Ye, Haotian Guo, Wentao Chen, Jia Jin, Yiran Wang, Pengfei Dai, Huili Shi, Hongru Tao et al. · 2023 · Cell Reports
- Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5′-Methylthioadenosine PhosphorylaseRoss Firestone, Scott A. Cameron, Jerome M. Karp, Vickery L. Arcus, Vern L. Schramm · 2016 · ACS Chemical Biology
- Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinomaJihao Xu, Wen‐Hsin Chang, Lon Wolf R. Fong, Robert H. Weiss, Sung‐Liang Yu, Ching‐Hsien Chen · 2019 · Signal Transduction and Targeted Therapy
- PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cellsMatthew S. Gillespie, Kelly Chiang, Gemma L. Regan-Mochrie, Soo‐Youn Choi, Ciara M. Ward, Debashish Sahay, Paloma García, Roland R. Arnold, Clare C. Davies · 2024 · Oncogene
- SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELOPatrícia Cristine Borck, Isabella Boyle, Kristina Janković, Nolan R. Bick, Kyla J. Foster, Anthony C. Lau, Lucy Parker-Burns, Daniel A. Lubicki, Tianxia Li, Ashir A. Borah et al. · 2025 · Nature
- Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcomaHaoran Mu, Qi Zhang, Dongqing Zuo, Jinzeng Wang, Yining Tao, Zhen Li, Xin He, Huanliang Meng, Hongsheng Wang, Jiakang Shen et al. · 2025 · Cell Reports Medicine
- Synthetic lethality in cancer drug discovery: challenges and opportunitiesEmanuel Gonçalves, Colm J. Ryan, David J. Adams · 2025 · Nature Reviews Drug Discovery
- The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell ActivationBénédikt Jacobs, Sebastian Schlögl, Carolin Dorothea Strobl, Simon Völkl, Andrej Stoll, Dimitrios Mougiakakos, Karl‐Johan Malmberg, Andréas Mackensen, Michael Aigner · 2020 · Frontiers in Immunology
- Keep a watchful eye on methionine adenosyltransferases, novel therapeutic opportunities for hepatobiliary and pancreatic tumoursPeiwen Yang, Juying Jiao, Zhen Chen, Xiaoyan Zhu, Chien‐shan Cheng · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Cryo-electron microscopy structure of a human PRMT5:MEP50 complexDavid E. Timm, Valorie D. Bowman, Russell E. Madsen, Charles T. Rauch · 2018 · PLoS ONE
- Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapyVerónica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna‐Lena Gustavsson, Lars Johansson, Adrian Ng, Casey O’Brien, Marios Giannakis et al. · 2020 · Nature Communications
- MAT2A inhibition combats metabolic and transcriptional reprogramming in cancerFadi E. Pulous, Barbara Steurer, Frank W. Pun, Man Zhang, Feng Ren, Alex A. Zhavoronkov · 2024 · Drug Discovery Today
- From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo EfficacyIan Sarvary, M. Vestergaard, Loris Moretti, Jan Andersson, Jorge Peiró Cadahía, Sanne Cowland, Thomas Flagstad, Thomas Franch, Alex Haahr Gouliaev, Gitte Husemoen et al. · 2025 · Journal of Medicinal Chemistry
- A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding ModeVineet Pande, Weimei Sun, Lijs Beke, Didier Berthelot, Dirk Brehmer, David Brown, Jordi Corbera, Steve Irving, Lieven Meerpoel, Thomas Nys et al. · 2020 · ACS Medicinal Chemistry Letters
- Glioblastoma and Methionine AddictionMark L. Sowers, Lawrence C. Sowers · 2022 · International Journal of Molecular Sciences
- Genomic alteration of MTAP/CDKN2A predicts sarcomatoid differentiation and poor prognosis and modulates response to immune checkpoint blockade in renal cell carcinomaWenhao Xu, Aihetaimujiang Anwaier, Wangrui Liu, Gaomeng Wei, Jiaqi Su, Xi Tian, Jing Xia, Yuanyuan Qu, Jian‐Yuan Zhao, Hailiang Zhang et al. · 2022 · Frontiers in Immunology
- Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?Sarah‐Maria Fendt · 2017 · Frontiers in Endocrinology
- The Transition-State Structure for Human MAT2A from Isotope EffectsRoss Firestone, Vern L. Schramm · 2017 · Journal of the American Chemical Society
- Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluationsKongkai Zhu, Cheng‐Shi Jiang, Hongrui Tao, Jingqiu Liu, Hua Zhang, Cheng Luo · 2018 · Bioorganic & Medicinal Chemistry Letters
- The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcriptionZhiwen Fan, Xiaocen Kong, Jun Xia, Xiaoyan Wu, He Li, Huihui Xu, Mingming Fang, Yong Xu · 2016 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunctionJacob M. Winter, Heidi L. Fresenius, Corey Nathaniel Cunningham, Peng Wei, Heather R. Keys, Jordan A. Berg, Alex J. Bott, Tarun Yadav, Jeremy A. Ryan, Deepika Sirohi et al. · 2022 · eLife
- Protein arginine methyltransferase 5–mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formationHe Liu, Xiaoliang Dong, Kunpeng Jia, Baohui Yuan, Zhengnan Ren, Xiaohua Pan, Jianjin Wu, Jiahong Li, Jingwen Zhou, Ruxing Wang et al. · 2023 · Cardiovascular Research
- PRMT5-mediated FUBP1 methylation accelerates prostate cancer progressionWeiwei Yan, Xun Liu, Xuefeng Qiu, Xuebin Zhang, Jiahui Chen, Kai Xiao, Ping Wu, Chao Peng, Xiaolin Hu, Zengming Wang et al. · 2024 · Journal of Clinical Investigation
- Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor ChemosensitizationChangzheng Du, Steven W. Li, Simranjit X. Singh, Kristen Roso, Michael A. Sun, Christopher J. Pirozzi, Rui Yang, Jian-Liang Li, Yiping He · 2021 · Molecular Cancer Research
- Deletion ofMTAPHighly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant MethioninaseYUSUKE AOKI, Yasunori Tome, Qinghong Han, Jun Yamamoto, Kazuyuki Hamada, NORIYUKI MASAKI, Yutaro Kubota, Michael Bouvet, Kotaro Nishida, Robert M. Hoffman · 2022 · Cancer Genomics & Proteomics
- Alterations of Histone Modifications in CancerAmir Hosseini, Saverio Minucci · 2018 · Elsevier eBooks
- Pancreatic Cancer Patient-Derived Organoid Platforms: A Clinical Tool to Study Cell- and Non-Cell-Autonomous Mechanisms of Treatment ResponseGeny Piro, Antonio Agostini, Alberto Larghi, Giuseppe Quero, Carmine Carbone, Annachiara Esposito, Gianenrico Rizzatti, Fabia Attili, Sergio Alfieri, Guido Costamagna et al. · 2021 · Frontiers in Medicine
- Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hitsChristopher R. Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G. Christensen, Robin J. Gunn, Anthony Ivetac, John M. Ketcham, Jon E. Kuehler, J. David Lawson et al. · 2022 · RSC Medicinal Chemistry
- Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and TreatmentChristopher A. Febres‐Aldana, Rachel E. Fanaroff, Michael David Offin, Marjorie Glass Zauderer, Jennifer L. Sauter, Soo‐Ryum Yang, Marc Ladanyi · 2023 · Annual Review of Pathology Mechanisms of Disease
- Metabolome profiling by widely-targeted metabolomics and biomarker panel selection using machine-learning for patients in different stages of chronic kidney diseaseYao-Hua Gu, Yu Chen, Qing Li, Neng‐Bin Xie, Xue Xing, Jun Xiong, Min Shan Hu, Tian-Zhou Li, Ke-Yu Yuan, Yu Liu et al. · 2024 · Chinese Chemical Letters
- Targeting purine metabolism-related enzymes for therapeutic intervention: A review from molecular mechanism to therapeutic breakthroughDi Wu, Shengqiang Yang, Chenyang Yuan, Kejia Zhang, Jiachen Tan, Kaifeng Guan, Hong Zeng, Chunjie Huang · 2024 · International Journal of Biological Macromolecules
- Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor MetabolismAshwini Kumar Sharma, Roland Eils, Rainer König · 2016 · Cancer Research
- Synthetic lethality: emerging targets and opportunities in melanomaNicola Thompson, David J. Adams, Marco Ranzani · 2017 · Pigment Cell & Melanoma Research
- Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine PhosphorylaseRajesh K. Harijan, Oskar Hoff, Rodrigo Gay Ducati, Ross Firestone, Brett M. Hirsch, Gary B. Evans, Vern L. Schramm, Peter C. Tyler · 2019 · Journal of Medicinal Chemistry
- Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient CellsYan Tang, Souheil El‐Chemaly, Angelo M. Taveira‐DaSilva, Hilary J. Goldberg, Shefali Bagwe, Iván O. Rosas, Joel Moss, Carmen Priolo, Elizabeth P. Henske · 2019 · CHEST Journal
- Protein arginine methylation in transcription and epigenetic regulationHoang Quoc Hai Pham, Xiaoqun Tao, Yanzhong Yang · 2023 · Frontiers in Epigenetics and Epigenomics
- Phase Ib and dose-expansion study of GSK3326595, a PRMT5 inhibitor as monotherapy and in combination with pembrolizumab in patients with advanced cancersM.M. Gounder, Patricia Martín-Romano, Antoîne Italiano, L. L. Siu, Philippe Alexandre Cassier, Gerald Steven Falchook, Izidore S. Lossos, Drew Warren Rasco, J.F. Hilton, Meredith Ann McKean et al. · 2025 · Annals of Oncology
- Magnetic-Driven Hydrogel Microrobots Selectively Enhance Synthetic Lethality in MTAP-Deleted OsteosarcomaHaoran Mu, Chenlu Liu, Qi Zhang, Huanliang Meng, Shimin Yu, Ke Zeng, Jing Han, Xinmeng Jin, Shi Shi, Peiyao Yu et al. · 2022 · Frontiers in Bioengineering and Biotechnology
- An update on small molecule compounds targeting synthetic lethality for cancer therapyJiaxiang Luo, Yang Li, Yiwen Zhang, Defa Wu, Yijiu Ren, Jie Liu, Chengdi Wang, Jifa Zhang · 2024 · European Journal of Medicinal Chemistry
- A compendium of Amplification-Related Gain Of Sensitivity genes in human cancerVerónica Rendo, Michaël Schubert, Nicholas Khuu, Maria F. Suárez Peredo Rodríguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle L. Swift, Yizhou Joseph He et al. · 2025 · Nature Communications
- In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancerJon Pey, Edurne San José‐Eneriz, María Carmen Ochoa, Iñigo Apaolaza, Pedro de Atauri, Ángel Rubio, Xabier Cendoya, Estíbaliz Miranda, Leire Gárate, Marta Cascante et al. · 2017 · Scientific Reports
- The Role of the PRMT5–SND1 Axis in Hepatocellular CarcinomaTanner Wright, Yalong Wang, Mark T. Bedford · 2021 · Epigenomes
- Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitorsChristopher R. Smith, Ruth Aranda, James G. Christensen, Lars D. Engstrom, Robin J. Gunn, Anthony Ivetac, John M. Ketcham, Jon E. Kuehler, J. David Lawson, Matthew A. Marx et al. · 2022 · Bioorganic & Medicinal Chemistry
- The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stabilityGiovanna Berto, Sébastien Ferreira-Cerca, Peter De Wulf · 2018 · Current Genetics
- Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 InductionXin Zhao, Bin Liu, William N. William, Kaloyan M. Tsanov, Yu-Jui Ho, Francisco M. Barriga, Raymond J. Lim, Maria Trifas, Azhar Khandekar, Yushen Du et al. · 2024 · Journal of Thoracic Oncology
- Nutrient control of splice site selection contributes to methionine addiction of cancerDawei Lin, Francisco Carranza, Stacey L. Borrego, Linda Lauinger, Lucas Dantas de Paula, Harika Reddy Pulipelli, Anna Andronicos, Klemens J. Hertel, Peter Kaiser · 2025 · Molecular Metabolism
- Load and lock: An emerging class of therapeutics that influence macromolecular dissociationRaymond J. Deshaies, Patrick Ryan Potts · 2025 · Science
- Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathwayKatey L. Witham, Rodney F. Minchin, Neville J. Butcher · 2016 · Biochemical Pharmacology
- Mechanism and Inhibition of Human Methionine Adenosyltransferase 2ACourtney N. Niland, Agnidipta Ghosh, Sean M. Cahill, Vern L. Schramm · 2021 · Biochemistry
- Scalable Atroposelective Synthesis of MRTX1719: An Inhibitor of the PRMT5/MTA ComplexMichał Achmatowicz, Thomas Scattolin, David R. Snead, Dinesh J. Paymode, Sahar Roshandel, Chen Xie, Guihui Chen, Cheng‐yi Chen · 2023 · Organic Process Research & Development
- Characterizing the Genomic Landscape of the Micropapillary Subtype of Urothelial Carcinoma of the Bladder Harboring Activating Extracellular Mutations of ERBB2Jessica M. Posada, Evgeny Yakirevich, Ashish M. Kamat, Akshay Sood, Joseph M Jacob, Gennady Bratslavsky, Petros D. Grivas, Philippe E. Spiess, Roger Li, Andrea Necchi et al. · 2024 · Modern Pathology
- Clinicopathological characterisation of MTAP alterations in gastrointestinal cancersGianluca Mauri, Giorgio Patelli, Laura Roazzi, Emanuele Valtorta, Alessio Amatu, Giovanna Marrapese, Erica Francesca Bonazzina, Federica Tosi, Katia Bruna Bencardino, Gabriele Ciarlo et al. · 2024 · Journal of Clinical Pathology
- Development of a Series of Pyrrolopyridone MAT2A InhibitorsStephen J. Atkinson, Sharan K. Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T. Collie, Ian L. Dale, Claudia De Fusco et al. · 2024 · Journal of Medicinal Chemistry
- Loss of MTAP Expression by Immunohistochemistry Is a Surrogate Marker for Homozygous 9p21.3 Deletion in Urothelial CarcinomaTatjana Vlajnic, Obinna Chijioke, Luca Roma, Spasenija Savic Prince, Tobias Zellweger, Cyrill A. Rentsch, Lukas Bubendorf · 2024 · Modern Pathology
- Nucleotide Metabolism Behind EpigeneticsTamaki Suganuma, Jerry L. Workman · 2021 · Frontiers in Endocrinology
- Advanced Squamous Cell Carcinomas of the Pelvic and Perineal Region: A Comprehensive Genomic Profiling StudyAndrea Necchi, Philippe E. Spiess, Marco Bandini, Giuseppe Basile, Petros D. Grivas, Gennady Bratslavsky, Joseph M Jacob, Natalie A. Danziger, Douglas I. Lin, Brennan James Decker et al. · 2022 · The Oncologist
- Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological AssaysFei Ye, Weiyao Zhang, Xiaoqing Ye, Jia Jin, Zhengbing Lv, Cheng Luo · 2018 · Journal of Chemical Information and Modeling
- Methionine Dependency and Restriction in Cancer: Exploring the Pathogenic Function and Therapeutic PotentialChi Ma, Aoshuang Xu, Liping Zuo, Qun Li, Fengjuan Fan, Yu Hu, Chunyan Sun · 2025 · Pharmaceuticals
- Cracking PRMT5: Mechanistic insights, clinical advances, and AI-driven strategiesFaranak Alipourgivi, Jing Su, Tao Lu · 2025 · Cancer Letters
- SCISSOR: a framework for identifying structural changes in RNA transcriptsHyo Young Choi, Heejoon Jo, Xiaobei Zhao, Katherine A. Hoadley, Scott Newman, Jeremiah Ray Holt, Michele C. Hayward, Michael I. Love, James Stephen Marron, David Neil Hayes · 2021 · Nature Communications
- Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP‐deficient lung cancerWen‐Hsin Chang, Yi‐Ju Chen, Yi‐Jing Hsiao, Ching-Cheng Chiang, Chia‐Yu Wang, Ya‐Ling Chang, Qi‐Sheng Hong, Shr‐Uen Lin, Shr‐Uen Lin, Gee‐Chen Chang et al. · 2022 · EMBO Reports
- Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data ScienceDarrin D. Stuart, Angel Guzman-Perez, Natasja Brooijmans, Erica L. Jackson, Gregory V. Kryukov, Adam A. Friedman, Axel Hoos · 2023 · Cancer Discovery
- Medicinal chemistry insights into PRMT5 inhibitorsZhihao Jiao, Yongmi Huang, Kexin Gong, Yiru Liu, Jinxiao Sun, Shangzhe Yu, Guisen Zhao · 2024 · Bioorganic Chemistry
- MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based DesignKevin M. Cottrell, Douglas A. Whittington, Kimberly J. Briggs, Haris Jahić, Janid A. Ali, Alvaro J. Amor, Deepali Gotur, Matthew R. Tonini, Wenhai Zhang, Alan Huang et al. · 2025 · Journal of Medicinal Chemistry
- Protein arginine methyltransferases and hepatocellular carcinoma: A reviewLei Yu, Ping Han, Dean Tian · 2021 · Translational Oncology