Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha +36 more·2016·Science
Cited by (623)
Items 101–200 of 623
- PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexesIshita Rehman, Suparna Mercy Basu, Subhendu Das, Sangheeta Bhattacharjee, Arijit Ghosh, Yves G. Pommier, Benu Brata Das · 2018 · Nucleic Acids Research
- Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapyEmily M. Smith, Wei Zhou, Polina Shindiapina, Saı̈d Sif, Chenglong Li, Robert A. Baiocchi · 2018 · Expert Opinion on Therapeutic Targets
- Functional Genomics for Cancer Drug Target DiscoveryBenjamin Haley, Filip Roudnicky · 2020 · Cancer Cell
- Metabolic heterogeneity and adaptability in brain tumorsChristian E. Badr, Daniel J. Silver, Florian A. Siebzehnrübl, Loic P. Deleyrolle · 2020 · Cellular and Molecular Life Sciences
- A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibitionChristopher E. Mahoney, David A. Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu et al. · 2019 · Nature Communications
- Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) InhibitorsHong Lin, Min Wang, Yang W. Zhang, Shuilong Tong, Raul Leal, Rupa S. Shetty, Kris Vaddi, Juan I. Luengo · 2019 · ACS Medicinal Chemistry Letters
- Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapyHayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik et al. · 2020 · Nature Communications
- Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistanceDonjeta Gjuka, Elio Adib, Kendra Garrison, Jianfeng Chen, Yuxue Zhang, Wenjiao Li, Daniel R. Boutz, Candice Lamb, Yuri Tanno, Amin H. Nassar et al. · 2023 · Cancer Cell
- Determinants of nutrient limitation in cancerMark R. Sullivan, Matthew G. Vander Heiden · 2019 · Critical Reviews in Biochemistry and Molecular Biology
- Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cellsClaudia Dominici, Nicolas Sgarioto, Zhenbao Yu, Laura Sesma-Sanz, Jean‐Yves Masson, Stéphane Richard, Noël J.‐M. Raynal · 2021 · Clinical Epigenetics
- Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cellsWen-Wei Liang, Simon Müller, Sydney K. Hart, H. Wessels, A. Méndez-Mancilla, Akash Sookdeo, Olivia Choi, Christina M. Caragine, Alba Corman, Lu Lu et al. · 2024 · Cell · Retracted
- Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor InteractionDavid C. McKinney, Brian J. McMillan, Matthew J. Ranaghan, Jamie A. Moroco, Merissa Brousseau, Zachary Mullin-Bernstein, Meghan O’Keefe, Patrick R. McCarren, Michael F. Mesleh, Kathleen M. Mulvaney et al. · 2021 · Journal of Medicinal Chemistry
- Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivationLauren Veronica Albrecht, Maggie H. Bui, Edward M. De Robertis · 2019 · Proceedings of the National Academy of Sciences
- Suppressive effects of tumor cell-derived 5′-deoxy-5′-methylthioadenosine on human T cellsFrederik C. Henrich, Katrin Singer, Kerstin Poller, Luise Bernhardt, Carolin Dorothea Strobl, Katharina Limm, Axel P. Ritter, Eva Gottfried, Simon Völkl, Bénédikt Jacobs et al. · 2016 · OncoImmunology
- Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosineYasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko‐Chien Chen, Anton H. Poral, Theresa Tammy Tran, Dimitra K. Georgiou, Kenisha Arthur et al. · 2021 · Nature Communications
- Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapyMarta Redondo-Muñoz, Francisco Javier Rodríguez‐Baena, Paula Aldaz, Adrià Caballé, Verónica Moncho-Amor, Maddalen Otaegi-Ugartemendia, Estefanía Carrasco‐García, Ana Olías-Arjona, Irene Lasheras-Otero, Eva Santamaría et al. · 2023 · Nature Metabolism
- Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic targetJohan Vande Voorde, Rory T. Steven, Arafath Kaja Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna González-Fernández, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki et al. · 2023 · Nature Metabolism
- The Bidirectional Relationship Between Cancer Epigenetics and MetabolismLuke Izzo, Hayley C. Affronti, Kathryn E. Wellen · 2020 · Annual Review of Cancer Biology
- MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic CancerQiangsheng Hu, Yi Qin, Shunrong Ji, Xiuhui Shi, Weixing Dai, Guixiong Fan, Shuo Li, Wenyan Xu, Wensheng Liu, Mengqi Liu et al. · 2021 · Cancer Research
- Arginine methyltransferases in normal and malignant hematopoiesisSarah Merin Greenblatt, Fan Liu, Stephen D. Nimer · 2016 · Experimental Hematology
- Metabolic Regulation of Methionine Restriction in DiabetesJie Yin, Wenkai Ren, Shuai Chen, Yuying Li, Hui Ling Han, Jing Gao, Gang Liu, Xin Wu, Yuying Li, Sung Woo Kim et al. · 2018 · Molecular Nutrition & Food Research
- Polyamine pathway activity promotes cysteine essentiality in cancer cellsTong Zhang, Christin Bauer, Alice C. Newman, Alejandro Huerta Uribe, Dimitris Athineos, Karen Blyth, Oliver D.K. Maddocks · 2020 · Nature Metabolism
- MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine StarvationLandon John Hansen, Ran Sun, Rui Ryan Yang, Simranjit X. Singh, Lee H. Chen, Christopher J. Pirozzi, Casey J. Moure, Carlee Hemphill, Austin B. Carpenter, Patrick N Healy et al. · 2019 · Cancer Research
- PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancerZhe Wang, Jing Kong, Ying Wu, Juliang Zhang, Ting Wang, Nanlin Li, Jing Fan, Hui Wang, Jian Zhang, Rui Ling · 2017 · Breast Cancer Research and Treatment
- MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trialMrinal M. Gounder, Melissa Lynne Johnson, Rebecca Suk Heist, Geoffrey Ira Shapiro, Sophie C. Postel-Vinay, Frederick Hugh Wilson, Elena Garralda, Gerburg M. Wulf, Caroline Almon, Salah Nabhan et al. · 2025 · Nature Communications
- Metabolic interactions with cancer epigeneticsXia Gao, Michael A. Reid, Mei Kong, Jason W. Locasale · 2016 · Molecular Aspects of Medicine
- Methyltransferase Inhibitors: Competing with, or Exploiting the Bound CofactorRenato Ferreira de Freitas, Danton Ivanochko, Matthieu Schapira · 2019 · Molecules
- CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohortStephanie Theresa Jünger, Felipe Da Matta Andreiuolo, Martin Mynarek, Inken Wohlers, Sven Rahmann, Ludger Klein‐Hitpaß, Evelyn Dörner, Anja zur Mühlen, Natalia Vélez Char, Katja von Hoff et al. · 2020 · Acta Neuropathologica
- LKB1 regulates PRMT5 activity in breast cancerHanine Lattouf, Loay Mohamed Hassan Kassem, Julien Jacquemetton, Ali Choucair, Coralie Poulard, Olivier Trédan, Laura Corbo, Mona Diab‐Assaf, Nader Hussein, Isabelle Treilleux et al. · 2018 · International Journal of Cancer
- Dual regulation of Arabidopsis AGO2 by arginine methylationPo Hu, Hongwei Zhao, Pei Zhu, Yongsheng Xiao, Weili Miao, Yinsheng Wang, Hailing Jin · 2019 · Nature Communications
- A PRMT5-RNF168-SMURF2 Axis Controls H2AX ProteostasisChangzheng Du, Landon John Hansen, Simranjit X. Singh, Feiyifan Wang, Ran Sun, Casey J. Moure, Kristen Roso, Paula K. Greer, Hai Yan, Yiping He · 2019 · Cell Reports
- A planetary health perspective on synthetic methionineCajetan Neubauer, Hannah L. Landecker · 2021 · The Lancet Planetary Health
- Emerging Opportunities for Target Discovery in Rare CancersTanaz Sharifnia, Andrew Lee Hong, Corrie Painter, Jesse S. Boehm · 2017 · Cell chemical biology
- All is not lost: learning from 9p21 loss in cancerPavlina Spiliopoulou, S.Y. Cindy Yang, Jeff P. Bruce, Ben X. Wang, Hal K. Berman, Trevor J. Pugh, Lillian L. Siu · 2022 · Trends in Immunology
- The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive BehaviorFlorian Weinberg, Nadine Reischmann, Lisa Fauth, Sanaz Taromi, Justin Mastroianni, M. Köhler, Sebastian Halbach, Andrea C. Becker, Niantao Deng, Tatjana Schmitz et al. · 2017 · EBioMedicine
- Skin Pigmentation Genetics for the ClinicStephen A. Ainger, Kasturee Jagirdar, Katie Lee, H. Peter Soyer, Richard A. Sturm · 2017 · Dermatology
- Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitorsHong Lin, Juan I. Luengo · 2019 · Bioorganic & Medicinal Chemistry Letters
- Protein arginine methyltransferase 5: a potential cancer therapeutic targetYuanyang Yuan, Hong Nie · 2021 · Cellular Oncology
- CDKN2A inhibits formation of homotypic cell-in-cell structuresLiang, Jianqing, Fan, Jie, Wang, Manna, Niu, Zubiao, Zhang, Zhengrong, Yuan, Long, Tai, Yanhong, Chen, Zhaolie, Song, Santai, Wang, Xiaoning et al. · 2018 · Oncogenesis
- Medicinal chemistry strategies targeting PRMT5 for cancer therapySiyu Fu, Qinwen Zheng, Dan Zhang, Congcong Lin, Liang Ouyang, Jifa Zhang, Lei Chen · 2022 · European Journal of Medicinal Chemistry
- Chemical Inhibition of Protein MethyltransferasesMatthieu Schapira · 2016 · Cell chemical biology
- Drug Discovery and Chemical Biology of Cancer EpigeneticsScott A. Ribich, Darren M. Harvey, Robert A. Copeland · 2017 · Cell chemical biology
- PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancerChang-Ching A. Lin, Tsung-Cheng Chang, Yunguan Wang, Lei Ming Guo, Yunpeng Gao, Emmanuel Bikorimana, Andrew S. Lemoff, Yisheng V. Fang, He Zhang, Yanfeng Zhang et al. · 2024 · Nature Communications
- Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and DifferentiationRui Ryan Yang, Lee H. Chen, Landon John Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, Bill H. Diplas, Matthew S. Waitkus, Paula K. Greer et al. · 2017 · Cancer Research
- Metabolic Rewiring and Redox Alterations in Malignant Pleural MesotheliomaUrso, Loredana, Cavallari, Ilaria, Sharova, Evgeniya, Ciccarese, Francesco, Pasello, Giulia, Ciminale, Vincenzo · 2020 · British Journal of Cancer
- Systematic profiling of conditional degron tag technologies for target validation studiesDaniel P. Bondeson, Zachary Mullin-Bernstein, Sydney Oliver, Thomas A. Skipper, Thomas C. Atack, Nolan R. Bick, Meilani Ching, Andrew A. Guirguis, Jason J. Kwon, Carly R. Langan et al. · 2022 · Nature Communications
- Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung CarcinomaHideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii et al. · 2018 · Cancer Research
- Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibitionCatherine Vander Linden, Cyril Corbet, Estelle Bastien, Ruben Martherus, Céline Guilbaud, Laurenne Petit, Loris Wauthier, Axelle E. Loriot, Charles De Smet, Olivier Féron · 2021 · Cell Reports
- Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibitionGabriel T. Bedard, Nord Gilaj, Karina Peregrina, Isabella Brew, Elena Tosti, Karl J. Shaffer, Peter C. Tyler, Winfried Edelmann, Leonard H. Augenlicht, Vern L. Schramm · 2023 · Journal of Biological Chemistry
- Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalitiesLiang Chang, Nancy Yoobin Jung, Adel Atari, Diego J. Rodriguez, Devishi Kesar, Tianyu Song, Matthew G. Rees, Melissa M. Ronan, Ruitong Li, Paloma A. Ruiz et al. · 2023 · Nature Genetics
- Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)R.L. Palte, Sebastian E. Schneider, Michael D. Altman, Robert P. Hayes, Shuhei Kawamura, Brian M. Lacey, My Sam Mansueto, Michael H. Reutershan, Phieng Siliphaivanh, Christopher Sondey et al. · 2020 · ACS Medicinal Chemistry Letters
- Long-read sequencing for non-small-cell lung cancer genomesYoshitaka Sakamoto, Liu Xu, Masahide Seki, Toshiyuki Yokoyama, Masahiro Kasahara, Yukie Kashima, Akihiro Ohashi, Yoko Shimada, Noriko Motoi, Katsuya Tsuchihara et al. · 2020 · Genome Research
- Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactionsChristopher J. Lord, Niall Quinn, Colm J. Ryan · 2020 · eLife
- Non-Histone Protein Methylation: Biological Significance and Bioengineering PotentialRoberto Di Blasi, Oleg B. Blyuss, John F. Timms, Daniel Conole, Francesca Ceroni, Harry J. Whitwell · 2021 · ACS Chemical Biology
- Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal CancersNatalie Y.L. Ngoi, Tin‐Yun Tang, Catia Fava Gaspar, Dean C. Pavlick, Gregory M. Buchold, Emma L. Scholefield, Vamsi Parimi, Richard S.P. Huang, Tyler Janovitz, Natalie A. Danziger et al. · 2024 · The Oncologist
- Targeting Protein Arginine Methyltransferase 5 in DiseaseAndré Richters · 2017 · Future Medicinal Chemistry
- Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious LeadsMingzong Li, Zenon D. Konteatis, Nelamangala V. Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Größ, Katya Marjon, Marc L. Hyer, Everton Mandley et al. · 2022 · Journal of Medicinal Chemistry
- The Structure and Function of the PRMT5:MEP50 ComplexStephen Antonysamy · 2017 · Sub-cellular biochemistry/Subcellular biochemistry
- Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative DiseasesRaquel Cuevas‐Díaz Durán, Chih-Yen Wang, Hui Zheng, Benjamin Deneen, Jia Qian Wu · 2019 · eNeuro
- Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic VulnerabilityRaunak Shrestha, Marta Llauradó, Amy Dawson, Joshua Hoenisch, Stanislav V. Volik, Yen‐Yi Lin, Shawn A. Anderson, Hannah H. Kim, Anne M. Haegert, Shane Colborne et al. · 2021 · Cancer Research
- The Influence of Arginine Methylation in Immunity and InflammationNivine Srour, Sarah Khan, Stéphane Richard · 2022 · Journal of Inflammation Research
- Targeting Arachidonic Acid Metabolism Enhances Immunotherapy Efficacy in ARID1A-Deficient Colorectal CancerLuying Cui, Ruiqi Liu, Shuling Han, Chunhui Zhang, Bojun Wang, Yuli Ruan, Xuefan Yu, Yien Li, Yuanfei Yao, Xin Guan et al. · 2024 · Cancer Research
- Antipurinergic therapy for autism—An in-depth reviewRobert K. Naviaux · 2017 · Mitochondrion
- SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growthHironari Tamiya, Hyungsoo Kim, Oleksiy Klymenko, Heejung Kim, Yongmei Feng, Tongwu Zhang, Ji Yun Han, Ayako Murao, Scott J. Snipas, Lucia B. Jilaveanu et al. · 2017 · Journal of Clinical Investigation
- Targeting allosteric regulation of cancer metabolismDaniel M. Kremer, Costas Andreas Lyssiotis · 2022 · Nature Chemical Biology
- Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP DeletionKevin M. Cottrell, Kimberly J. Briggs, Alice Tsai, Matthew R. Tonini, Douglas A. Whittington, Shanzhong Gong, Colin Liang, Patrick R. McCarren, Minjie Zhang, Wenhai Zhang et al. · 2025 · Journal of Medicinal Chemistry
- The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of CancerRyan V. Quiroz, Michael H. Reutershan, Sebastian E. Schneider, David L. Sloman, Brian M. Lacey, Brooke M. Swalm, Charles See Yeung, Craig R. Gibeau, Daniel S. Spellman, Danica A. Rankic et al. · 2021 · Journal of Medicinal Chemistry
- Arginine methyltransferase PRMT5 methylates and destabilizes Mxi1 to confer radioresistance in non-small cell lung cancerXijie Yang, Zhen Zeng, Xiaohua Jie, Ye Wang, Jun Han, Zhikun Zheng, Jinsong Li, Hongli Liu, Xiaorong Dong, Gang Wu et al. · 2022 · Cancer Letters
- Methylthioadenosine phosphorylase deficiency in tumors: A compelling therapeutic targetNa Fan, Yi Zhang, Suyun Zou · 2023 · Frontiers in Cell and Developmental Biology
- FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletionYichao Fan, Jiao Yue, Mengtao Xiao, Han Han‐Zhang, Yao Vickie Wang, Chun Ma, Zhilin Deng, Yingxiang Li, Yanyan Yu, Xinghao Wang et al. · 2017 · eLife
- Aneuploid CTC and CECPeter Ping Lin · 2018 · Diagnostics
- Preclinical Models of Malignant MesotheliomaJoseph R. Testa, Anton J. M. Berns · 2020 · Frontiers in Oncology
- MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarizationLandon John Hansen, Rui Yang, Kristen Roso, Wenzhe Wang, Lee Chen, Qing Yang, Christopher J. Pirozzi, Yiping He · 2022 · Scientific Reports
- Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutationsYuxuan Che, Yang Liu, Yixin Yao, Holly Ann Hill, Yijing Li, Qingsong Cai, Fangfang Yan, Preetesh Jain, Wei Wang, Lixin Rui et al. · 2023 · Blood Cancer Journal
- The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethalityChandler Bray, Cristina Domingo Balcells, Iain A. McNeish, Hector C. Keun · 2023 · Frontiers in Oncology
- Immune Checkpoint Therapy Combinations in Adult Advanced MiT Family Translocation Renal Cell CarcinomasOmar Alhalabi, Jonathan Thouvenin, Sylvie Négrier, Yann Alexandre Vano, Luca Campedel, Elshad Hasanov, Ziad Bakouny, Andrew Warren Hahn, Mehmet Asım Bilen, Pavlos Msaouel et al. · 2023 · The Oncologist
- Clinical study of genomic drivers in pancreatic ductal adenocarcinomaMichael T. Barrett, Ray Deiotte, Elizabeth Lenkiewicz, Smriti Malasi, Tara Holley, Lisa Evers, Richard G. Posner, Timothy Jones, Haiyong Han, Mark Sausen et al. · 2017 · British Journal of Cancer
- Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue contextJunfeng Bi, Sihan Wu, Wenjing Zhang, Paul S. Mischel · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- BRAF V600E mutation and 9p21: CDKN2A/B and MTAP co-deletions - Markers in the clinical stratification of pediatric gliomasLaura Frazão, Maria do Carmo Martins, Vasco Moura Nunes, José Pimentel, Cláudia C. Faria, José Miguéns, Amets Sagarribay, Mário Matos, Duarte Salgado, Sofia Nunes et al. · 2018 · BMC Cancer
- Systemic Therapy of Metastatic Pancreatic Adenocarcinoma: Current Status, Challenges, and OpportunitiesSakti Chakrabarti, Mandana Kamgar, Amit Mahipal · 2022 · Cancers
- Small molecule targeting of chromatin writers in cancerAndrew R. Conery, Jennifer L. Rocnik, Patrick Trojer · 2021 · Nature Chemical Biology
- Genome-guided discovery of cancer therapeutic targetsPrathyusha Konda, Simon Garinet, Eliezer M. Van Allen, Srinivas Raghavan Viswanathan · 2023 · Cell Reports
- Pan-cancer clinical and molecular landscape of MTAP deletion in nationwide and international comprehensive genomic dataHiroaki Ikushima, Kousuke Watanabe, Aya Shinozaki‐Ushiku, Katsutoshi Oda, Hidenori Kage · 2025 · ESMO Open
- Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancerYunhua Liu, Hanchen Xu, Kevin Van der Jeught, Yujing Li, Sheng Liu, Lu Zhang, Yuanzhang Fang, Xinna Zhang, Milan Radovich, Bryan Paul Schneider et al. · 2018 · Journal of Clinical Investigation · Retracted
- The Comprehensive Roles of ATRANORIN, A Secondary Metabolite from the Antarctic Lichen Stereocaulon caespitosum, in HCC TumorigenesisYoung-Jun Jeon, Sanghee Kim, Ji Hee Kim, Ui Joung Youn, Sung‐Suk Suh · 2019 · Molecules
- Nutrient availability shapes methionine metabolism in p16/ MTAP -deleted cellsSydney M. Sanderson, Peter G. Mikhael, Vijyendra Ramesh, Ziwei Dai, Jason W. Locasale · 2019 · Science Advances
- Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTACarolin Dorothea Strobl, Stefanie Schaffer, Tabea Haug, Simon Völkl, Katrin Peter, Katrin Singer, Martin Böttcher, Dimitrios Mougiakakos, Andréas Mackensen, Michael Aigner · 2019 · Molecular Cancer Therapeutics
- Potent and selective PTDSS1 inhibitors induce collateral lethality in cancers with PTDSS2 deletionYoshihama, Yohei, Namiki, Hidenori, Kato, Taiga, Shimazaki, Naomi, Takaishi, Sachiko, Kadoshima-Yamaoka, Kumiko, Yukinaga, Hideo, Maeda, Naoyuki, Shibutani, Tomoko, Fujimoto, Kazunori et al. · 2022 · Cancer Research
- TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancersKimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik Wilker et al. · 2025 · Translational Oncology
- Specific Targeting of MTAP -Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-MethylthioadenosineBaiqing Tang, Hyung‐Ok Lee, Serim S. An, Kathy Qi Cai, Warren D. Kruger · 2018 · Cancer Research
- Structure-Aided Design, Synthesis, and Biological Evaluation of Potent and Selective Non-Nucleoside Inhibitors Targeting Protein Arginine Methyltransferase 5Deqin Rong, Kaixin Zhou, Wei Fang, Hong Jun Yang, Yi Zhang, Qiongyu Shi, Yuting Huang, Jiayi Li, Hui Fen Dong, Lanlan Li et al. · 2022 · Journal of Medicinal Chemistry
- Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and BeyondCarolina N. Franco, Laurence J. Seabrook, Steven T. Nguyen, Jack T. Leonard, Lauren Veronica Albrecht · 2022 · Metabolites
- Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusionsJulia Schöpf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann et al. · 2024 · Nature Communications
- PRMT5 silencing selectively affects MTAP‐deleted mesothelioma: In vitro evidence of a novel promising approachMarcella Barbarino, Daniele Cesari, Maria Bottaro, Luca Luzzi, Asadoor Amirkhani Namagerdi, Franca Maria Bertolino, Cristiana Bellan, Fabrizio Proietti, Pasquale Somma, Mariacarolina Micheli et al. · 2020 · Journal of Cellular and Molecular Medicine
- Epigenetic drug screening defines a PRMT5 inhibitor–sensitive pancreatic cancer subtypeFelix Orben, Katharina Lankes, Christian Schneeweis, Zonera Hassan, Hannah Jakubowsky, Lukas Krauß, Fabio Boniolo, Carolin Schneider, Arlett Schäfer, Janine Murr et al. · 2022 · JCI Insight
- Cancer Dependencies: PRMT5 and MAT2A in MTAP/p16-Deleted CancersKatya Marjon, Peter Kalev, Kevin M. Marks · 2020 · Annual Review of Cancer Biology
- MTAP as an emerging biomarker in thoracic malignanciesMagdalena M. Brune, Spasenija Savic Prince, Tatjana Vlajnic, Obinna Chijioke, Luca Roma, David König, Lukas Bubendorf · 2024 · Lung Cancer
- Genomics-guided pre-clinical development of cancer therapiesHayley E. Francies, Ultan McDermott, Mathew J. Garnett · 2020 · Nature Cancer
- Identification of PRMT5 as a therapeutic target in cholangiocarcinomaJasmin Elurbide, Leticia Colyn, Maria Ujue Latasa, Iker Uriarte, Stefano Mariani, Amaya López-Pascual, Emiliana Valbuena-Goiricelaya, Borja Castelló-Uribe, Robert Arnes‐Benito, Elena Adán-Villaescusa et al. · 2024 · Gut
- Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinomaPeng Sen Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Ge Yang, Shu-Peng Wang, Song Wu · 2018 · BMC Cancer