The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing
Abstract
Rapid mixing to race past rearrangement: Chemistry relies on encounters between reactive partners. Sometimes one of the partners changes shape during the wait, spoiling the desired outcome. Kim et al. designed a microfluidic device to keep such botched encounters from happening. The device operates at low temperatures to keep individual reactants from isomerizing. It also achieves fast flow rates to maximize encounters between reactants on a microsecond time scale. The authors showcase the device by achieving bimolecular carbon-carbon coupling before one of the reagents can undergo a Fries rearrangement that would shift a neighboring group to the coupling site. Science , this issue p. 691
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Cites
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Cited by
The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Expanding the medicinal chemistry synthetic toolbox
Boström, J., Brown, D. G., Young, R. J., & Keserü, G. M. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.116 · Cited by 665
A field guide to flow chemistry for synthetic organic chemists
Capaldo, L., Wen, Z., & Noël, T. (2023) · Chemical Science · doi:10.1039/d3sc00992k · Cited by 402
Lin, S., Yu, Z., Chen, D., Wang, Z., Miao, J., Li, Q., Zhang, D., Song, J., & Cui, D. (2020) · Small · doi:10.1002/smll.201903916 · Cited by 353
How to approach flow chemistry
Guidi, M., Seeberger, P. H., & Gilmore, K. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00832b · Cited by 253
Metadata
- Authors
- Kim, H., Min, K.-I., Inoue, K., Im, D. J., Kim, D.-P., & Yoshida, J.-I.
- Venue
- Science
- Published
- 2016-05-06
- Volume
- 352
- Issue
- 6286
- Pages
- 691-694
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2346720530
- Cited by
- 271
- References
- 1
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, H., Min, K.-I., Inoue, K., Im, D. J., Kim, D.-P., & Yoshida, J.-I. (2016). Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing. Science. https://doi.org/10.1126/science.aaf1389
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
