The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Synaptic mechanisms of pattern completion in the hippocampal CA3 network
Abstract
The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording from up to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence, divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion. Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.
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Lisman, J., Buzsáki, G., Eichenbaum, H., Nadel, L., Ranganath, C., & Redish, A. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4661 · Cited by 851
Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons
Cembrowski, M. S., & Spruston, N. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0125-5 · Cited by 258
Hippocampal reactivation of random trajectories resembling brownian diffusion
Stella, F., Baracskay, P., O’Neill, J., & Csicsvari, J. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.052 · Cited by 107
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Beaulieu-Laroche, L., & Harnett, M. T. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.016 · Cited by 79
The Cerebellar Mossy Fiber Synapse as a Model for High-Frequency Transmission in the Mammalian CNS
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Metadata
- Authors
- Guzman, S. J., Schlögl, A., Frotscher, M., & Jonas, P.
- Venue
- Science
- Published
- 2016-09-09
- Volume
- 353
- Issue
- 6304
- Pages
- 1117-1123
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2517175011
- Cited by
- 285
- References
- 68
- FWCI
- 17.04
- Type
- journal article
- Language
- en
- Open access
- closed
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