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Cited by 375

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Inflammatory neuroprotection following traumatic brain injury

Open access
Russo, Matthew V., McGavern, Dorian B.·2016·Science

Abstract

Traumatic brain injury (TBI) elicits an inflammatory response in the central nervous system (CNS) that involves both resident and peripheral immune cells. Neuroinflammation can persist for years following a single TBI and may contribute to neurodegeneration. However, administration of anti-inflammatory drugs shortly after injury was not effective in the treatment of TBI patients. Some components of the neuroinflammatory response seem to play a beneficial role in the acute phase of TBI. Indeed, following CNS injury, early inflammation can set the stage for proper tissue regeneration and recovery, which can, perhaps, explain why general immunosuppression in TBI patients is disadvantageous. Here, we discuss some positive attributes of neuroinflammation and propose that inflammation be therapeutically guided in TBI patients rather than globally suppressed.

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Crossref · 10.1126/science.aaf6260

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Metadata

Authors
Russo, M. V., & McGavern, D. B.
Venue
Science
Published
2016-08-19
Volume
353
Issue
6301
Pages
783-785
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2507842763
Cited by
375
References
7
FWCI
18.45
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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