Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497

RAG-1-deficient mice have no mature B and T lymphocytes

Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898

Genetics and pathogenesis of inflammatory bowel disease

Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,733

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358

The microbiome and innate immunity

Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,465

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412

Perspective on alcohol-induced organ damage via autophagy-dependent cellular changes

Bakheet, A., Anbazhagan, M., Barve, S. S., Dasarathy, S., Dickinson, J. J., Ding, W., Donohue, T. M., Gopal, T., Gukovskaya, A. S., Kharbanda, K. K., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103879 · Cited by 17

The transplantation of the gut microbiome of fat-1 mice protects against colonic mucus layer disruption and endoplasmic reticulum stress induced by high fat diet

Bourragat, A., Escoula, Q., Bellenger, S., Zemb, O., Beaumont, M., Chaumonnot, K., Farine, J., Jacotot, E., Bonnotte, A., Avoscan, L., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2356270 · Cited by 18

Intestinal granular cells of a cartilaginous fish, thornback ray Raja clavata: Morphological characterization and expression of different molecules

Dezfuli, B. S., Manera, M., Bosi, G., Merella, P., DePasquale, J. A., & Giari, L. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.02.019 · Cited by 16

RNA-binding proteins and long noncoding RNAs in intestinal epithelial autophagy and barrier function

Xiao, L., Rao, J. N., & Wang, J. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.1895648 · Cited by 16

An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death

Terraza-Silvestre, E., Villamuera, R., Bandera-Linero, J., Letek, M., Oña-Sánchez, D., Ramón-Barros, C., Moyano-Jimeno, C., & Pimentel‐Muiños, F. X. (2025) · Nature Communications · doi:10.1038/s41467-025-58619-3 · Cited by 18

Highlights on two decades with microbiota and inflammatory bowel disease from etiology to therapy

Hussein, I. H., Dosh, L., Qassab, M. A., Jurjus, R. A., Masri, J. E., Nader, C. A., Rappa, F., Leone, A., & Jurjus, A. R. (2023) · Transplant Immunology · doi:10.1016/j.trim.2023.101835 · Cited by 17

Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery

Ding, Y., Xing, D., Fei, Y., Luo, S., & Lu, B. (2024) · Medicine Plus · doi:10.1016/j.medp.2023.100004 · Cited by 16

Intestinal lysozyme engagement of Salmonella Typhimurium stimulates the release of barrier-impairing InvE and Lpp1

Han, J., Balasubramanian, I., Flores, J. A., Bandyopadhyay, S., Yang, J., Liu, Y., Singh, R., Setty, P., Kiela, P. R., Ferraris, R. P., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107424 · Cited by 15

Autophagy and Immune-Related Diseases

Tan, P., Ye, Y., Mao, J., & He, L. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-0606-2_10 · Cited by 15

Localisation of Cannabinoid and Cannabinoid-Related Receptors in the Horse Ileum

Galiazzo, G., Tagliavia, C., Giancola, F., Rinnovati, R., Sadeghinezhad, J., Bombardi, C., Grandis, A., Pietra, M., & Chiocchetti, R. (2021) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2021.103688 · Cited by 17

Gut Microbiome Alterations following Postnatal Iron Supplementation Depend on Iron Form and Persist into Adulthood

McMillen, S. A., Thomas, S. P., Liang, E., Nonnecke, E. B., Slupsky, C. M., & Lönnerdal, B. L. (2022) · Nutrients · doi:10.3390/nu14030412 · Cited by 15

Multifaceted involvements of Paneth cells in various diseases within intestine and systemically

Cui, C., Wang, X., Li, L., Wei, H., & Peng, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1115552 · Cited by 17

Microbial Infections as a Trigger for Acute-on-Chronic Liver Failure: A Review

Cai, Q., Liu, W., Zhu, M., & Sheng, J. (2019) · Medical Science Monitor · doi:10.12659/msm.915637 · Cited by 17

Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection

Kroon, S., & Hardt, W. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf038 · Cited by 14

Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases

Kuramoto, K., & He, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844481 · Cited by 16

Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy

Yan, W., Chen, S., Wang, Y., You, Y., Lu, Y., Wang, W., Wu, B. Y., Du, J., Peng, S., Cai, W., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05785-7 · Cited by 14

Effects of methylglyoxal on intestine and microbiome composition in aged mice

Tirelli, E., Pucci, M., Squillario, M., Bignotti, G., Messali, S., Zini, S., Bugatti, M., Cadei, M., Memo, M., Caruso, A., et al. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115276 · Cited by 13

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Wu, J., Duan, Y., Cui, J., Dong, Y., Li, H., Wang, M., Fan, S., Li, D., & Li, Y. (2019) · Journal of Radiation Research · doi:10.1093/jrr/rrz065 · Cited by 14

Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

Aguilar, C., Costa, S., Maudet, C., Vivek-Ananth, R. P., Zaldívar‐López, S., Garrido, J. J., Samal, A., Mano, M., & Eulálio, A. (2021) · Nature Communications · doi:10.1038/s41467-021-23593-z · Cited by 14

Secretory Autophagosomes from Alveolar Macrophages Exacerbate Acute Respiratory Distress Syndrome by Releasing IL-1β

Xu, X., Liu, X., Dong, X., Qiu, H., Yang, Y., & Liu, L. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s344857 · Cited by 14

Improved antibacterial performance using hydrogel-immobilized lysozyme as a catalyst in water

Ye, Y., Klimchuk, S., Shang, M., & Niu, J. (2019) · RSC Advances · doi:10.1039/c9ra02464f · Cited by 14

Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids

Iribarren, C., Nordlander, S., Sundin, J., Isaksson, S., Savolainen, O. I., Törnblom, H., Magnusson, M. K., Simrén, M., & Öhman, L. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14390 · Cited by 13

HuR and Its Interactions with Noncoding RNAs in Gut Epithelium Homeostasis and Diseases

Sharma, S., Xiao, L., & Wang, J. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2810262 · Cited by 14

SARS-CoV-2 Spike protein triggers gut impairment since mucosal barrier to innermost layers: From basic science to clinical relevance

do Nascimento, R. R., de Aquino, C. C., de Sousa, J. K., Gadelha, K. K. L., Cajado, A. G., Schiebel, C. S., Dooley, S. A., Sousa, P. A., Rocha, J. A., Medeiros, J. V. R., et al. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.03.009 · Cited by 13

Autophagy and Extracellular Vesicles in Colorectal Cancer: Interactions and Common Actors?

Auger, C., Christou, N., Brunel, A., Perraud, A., & Verdier, M. (2021) · Cancers · doi:10.3390/cancers13051039 · Cited by 14

To be or not to be cell autonomous? Autophagy says both

Fenouille, N., Nascimbeni, A. C., Botti, J., Dupont, N., Morel, É., & Codogno, P. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170025 · Cited by 15

No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture

van Ziel, A. M., Wolzak, K., Nölle, A., Hoetjes, P. J., Berenjeno‐Correa, E., van Anken, E., Struys, E. A., & Scheper, W. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14856 · Cited by 13

Dithizone-induced Paneth cell disruption significantly decreases intestinal perfusion in the murine small intestine

Berger, J. N., Gong, H., Good, M. L., & McElroy, S. J. (2019) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2019.02.021 · Cited by 15

Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging

Zhang, C., Zhao, X., Zhang, H., Wang, T., Zhang, Z., Yin, Y., Wang, H., Tong, X., Xue, Y., Zhou, Y., et al. (2025) · Research · doi:10.34133/research.0704 · Cited by 12

Smart chitosan-based microgels for enhanced photothermal-assisted antibacterial activity

Gong, H., Liu, L., Zhou, J., Li, H., Qiu, J., & Cheng, W. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126389 · Cited by 12

Regulation of interferon signaling in response to gut microbes by autophagy

Martin, P. K., & Cadwell, K. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1614395 · Cited by 12

Autophagy and Bacterial infections

Cadwell, K., Abraham, C., Bel, S., Chauhan, S., Coers, J., Colombo, M. I., Davis, J. R., Hofius, D., Nguyen, H. T. T., Ogawa, M., et al. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2542904 · Cited by 12

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice

Canale, V., Spalinger, M. R., Alvarez, R., Sayoc-Becerra, A., Sanati, G., Manz, S., Chatterjee, P., Santos, A. N., Lei, H., Jahng, S., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.03.009 · Cited by 12

Heterozygosity for Crohn’s Disease Risk Allele of ATG16L1 Protects against Bacterial Infection

Yao, X., Rudensky, E., Martin, P. K., Miller, B. M., Vargas, I., Zwack, E. E., Lacey, K. A., He, Z., Furtado, G. C., Lira, S. A., et al. (2024) · Immunity · doi:10.1016/j.immuni.2025.04.023 · Cited by 13

Biogenesis and homeostasis of mast cell lysosome related secretory granules

Sagi‐Eisenberg, R. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1603999 · Cited by 11

Secretory Autophagosomes from Alveolar Macrophages Exacerbate Acute Respiratory Distress Syndrome by Releasing IL-1β

Xu, X., Liu, X., Dong, X., Qiu, H., Yang, Y., & Liu, L. (2022) · Dove Medical Press (Taylor and Francis Group) · Cited by 11

Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction

Williams, P. A., Naughton, K. E., Simon, L. A., Soto, G. E., Parham, L. R., Ma, X., Danan, C. H., Hu, W., Friedman, E. S., McMillan, E. A., et al. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00248.2022 · Cited by 11

The road to Crohn's disease

Kaser, A., & Blumberg, R. S. (2017) · Science · doi:10.1126/science.aao4158 · Cited by 12

Nonlytic Egress and Transmission in the Virus World

Altan‐Bonnet, N., & Panigrahi, M. (2025) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052521-120140 · Cited by 11

Expression characteristics and in vitro antibacterial properties of C-type lysozyme in crucian carp infected with Aeromonas salmonicida

Ling, X.-D., Lv, J., Chen, F.-J., Qin, X., Wu, M.-S., Bai, F., & Luo, H.-Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24044 · Cited by 10

Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms

Quiniou, G., Andromaque, L., Duclaux‐Loras, R., Dinet, O., Cervantes, O., Verdet, M., Meunier, C., Boschetti, G., Viret, C., Nancey, S., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2338574 · Cited by 10

Picornavirus security proteins promote the release of extracellular vesicle enclosed viruses via the modulation of host kinases

Defourny, K. A. Y., Pei, X., van Kuppeveld, F. J. M., & Hoen, E. N. M. N. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012133 · Cited by 10

Noncoding Vault RNA1-1 Impairs Intestinal Epithelial Renewal and Barrier Function by Interacting With CUG-binding Protein 1

Sharma, S., Xiao, L., Chung, H. K., Chen, T., Mallard, C. G., Warner, B., Yu, T., Kwon, M. S., Chae, S., Raufman, J., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101410 · Cited by 10

Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis

Iliopoulou, L., Tzaferis, C., Prados, A., Roumelioti, F., Koliaraki, V., & Kollias, G. A. (2025) · Nature Communications · doi:10.1038/s41467-025-57570-7 · Cited by 10

The gut-heart axis: a correlation between Paneth cells’ dysfunction, microbiome dysbiosis, and cardiovascular diseases

Rezabakhsh, A., Habtemariam, S., Parvizi, R., Meddahi‐Pellé, A., Rodriguez‐Ruiz, V., Pavon‐Djavid, G., & Barzgari, A. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02335-4 · Cited by 11

Autophagy and Apoptosis in Inflammatory Bowel Disease

Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2023) · Gastroenterology Insights · doi:10.3390/gastroent14040042 · Cited by 10

The signature of the small intestinal epithelial and immune cells in health and diseases

Gao, X., Yang, C., Feng, Z., Liu, P., & Liu, Z. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003615 · Cited by 12

Autophagy and ncRNAs: Dangerous Liaisons in the Crosstalk between the Tumor and Its Microenvironment

Eng, G. W. L., Zheng, Y., Yap, D. W. T., Teo, A. Y. T., & Cheong, J. K. (2021) · Cancers · doi:10.3390/cancers14010020 · Cited by 9

Alleviation of Hepatic Steatosis: Dithizone-Related Gut Microbiome Restoration During Paneth Cell Dysfunction

Zhang, S., Tun, H. M., Zhang, D., Chau, H.-T., Huang, F., Kwok, H. F., Wong, D. K.-H., Mak, L., Yuen, M., & Seto, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.813783 · Cited by 9

Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome-like exocrinopathy

Suzuki, A., Iwaya, C., Ogata, K., Yoshioka, H., Shim, J., Tanida, I., Komatsu, M., Tada, N., & Iwata, J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04334-x · Cited by 9

SQSTM1/p62 promotes miR-198 loading into extracellular vesicles and its autophagy-related secretion

Yu, X., Eischeid-Scholz, H., Meder, L., Kondylis, V., Büttner, R., & Odenthal, M. (2022) · Human Cell · doi:10.1007/s13577-022-00765-7 · Cited by 9

Enhanced expression of HNF4α during intestinal epithelial differentiation is involved in the activation of ER stress

Tunçer, S., Sade‐Memişoğlu, A., Keşküş, A. G., Sheraj, I., Güner, G., Akyol, A., & Banerjee, S. (2019) · FEBS Journal · doi:10.1111/febs.15152 · Cited by 9

Advances in Autophagy–Lysosomal Pathway and Neurodegeneration via Brain–Gut Axis

Yao, P., & Han, H. (2025) · Biomedicines · doi:10.3390/biomedicines13061390 · Cited by 10

Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant UBB+1

Wagh, A. R., & Glickman, M. (2025) · bioRxiv · doi:10.1073/pnas.2504528122 · Cited by 8

Neonatal microbiota-epithelial interactions that impact infection

Negi, S., Hashimoto‐Hill, S., & Alenghat, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.955051 · Cited by 9

Intra-Amniotic Administration—An Emerging Method to Investigate Necrotizing Enterocolitis, In Vivo (Gallus gallus)

Kolba, N., Cheng, J., Jackson, C., & Tako, E. (2022) · Nutrients · doi:10.3390/nu14224795 · Cited by 8

MiR-199a-3p-regulated alveolar macrophage-derived secretory autophagosomes exacerbate lipopolysaccharide-induced acute respiratory distress syndrome

Xu, X., Liu, X., Dong, X., Yang, Y., & Liu, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1061790 · Cited by 8

A new way out for lysozyme

Starling, S. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.118 · Cited by 8

Goblet and Paneth Cells: Producers of the Intestinal Barrier

Modilevsky, S., Naama, M., & Bel, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00140-1 · Cited by 8

Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitis

Yang, J., & Shi, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1184159 · Cited by 8

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

Prochera, A., Muppirala, A. N., Kuziel, G. A., Soualhi, S., Shepherd, A., Sun, L., Issac, B., Rosenberg, H. J., Karim, F., Perez, K., et al. (2025) · eLife · doi:10.7554/elife.97144.3 · Cited by 7

Huangqin decoction alleviated irinotecan-induced diarrhea by inhibiting endoplasmic reticulum stress through activating AMPK/mTOR-mediated autophagy

He, Y., Feng, L., Gao, Y., Wang, Y., Yang, C., Han, S., Ren, Y., Zhai, Y., & Nie, K. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119790 · Cited by 7

A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer

Wu, T., Li, T., Zhang, C., Tian, Y., Li, H., He, Y., Xu, Y. L., Gong, T., Zhao, J., & Wang, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-62880-x · Cited by 7

Butyrate-producing commensal bacteria confers colon immune defense function via enhancing H4K31 Crotonylation of macrophages

Wu, J., Guo, P., Wang, M., Men, Z., Lin, Z., Wang, J., Zhang, S., Zhou, M., Zhao, J., Liu, H., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02234-3 · Cited by 7

Cell Surface Modification-Mediated Primary Intestinal Epithelial Cell Culture Platforms for Assessing Host–Microbiota Interactions

Sittipo, P., Anggradita, L. D., Kim, H., Lee, C., Hwang, N. S.-Y., Lee, Y. K., & Hwang, Y. (2024) · Biomaterials Research · doi:10.34133/bmr.0004 · Cited by 9

Identification and Characterization of Multiple Paneth Cell Types in the Mouse Small Intestine

Timmermans, S., Wallaeys, C., García-González, N., Pollaris, L., Saeys, Y., & Libert, C. (2024) · Cells · doi:10.3390/cells13171435 · Cited by 7

Cell Type– and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A

Varma, M., Kadoki, M., Lefkovith, A. J., Conway, K. L., Gao, K. M., Mohanan, V., Tusi, B. K., Graham, D. B., Latorre, I. J., Tolonen, A. C., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900750 · Cited by 8

Ribonuclease1 contributes to the antibacterial response and immune defense in blunt snout bream (Megalobrama amblycephala)

Chen, J., Huang, X., Geng, R., Zhu, D., Wang, W., & Liu, H. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.066 · Cited by 7

Deciphering the role of autophagy in the immunopathogenesis of inflammatory bowel disease

Li, Y., & Law, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1070184 · Cited by 9

Gene/Environment Interaction and Autoimmune Disease

Harris-Tryon, T. A., & Bel, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-35213-4_8 · Cited by 6

A metabolic labeling way to in situ fabricate bacterial FRET Platform for innate immune defence molecule

Zhang, Z., Han, Q., Lau, J. W., Wang, Z., Hu, M., Qiu, H., Cong, T. D., & Xing, B. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130913 · Cited by 7

Mechanobiological Approach for Intestinal Mucosal Immunology

Kim, H., Lee, S.-H., & Yang, J.-Y. (2025) · Biology · doi:10.3390/biology14020110 · Cited by 6

Chats and Spats of Autophagy and Innate Immune Systems

Kundu, S., Chauhan, S. C., Dhar, K., Varahan, S., & Chauhan, S. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169387 · Cited by 6

Regulation of Gut Barrier Function by RNA-Binding Proteins and Noncoding RNAs

Chung, H. K., Rao, J. N., & Wang, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00059-1 · Cited by 6

A new way out for lysozyme

Starling, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.98 · Cited by 6

Lactobacillus acidophilus protects against Corynebacterium pseudotuberculosis infection by regulating the autophagy of macrophages and maintaining gut microbiota homeostasis in C57BL/6 mice

Li, D., Jiang, Y., Cui, Z., Ma, M., Zhu, F., Li, G., Yang, H., Li, S., Zhang, T., Chen, D., et al. (2024) · mSystems · doi:10.1128/msystems.00484-24 · Cited by 5

Mouse Paneth Cell-Enriched Proteome Enabled by Laser Capture Microdissection

Woo, J. J., Schoenfeld, M., Sun, X., Iraguha, T., Zhou, Z., & Zhang, Q. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00311 · Cited by 5

Myeloid vitamin D receptor regulates Paneth cells and microbial homeostasis

Bakke, D., Zhang, J., Zhang, Y., Ogbu, D., Xia, Y., & Sun, J. (2023) · The FASEB Journal · doi:10.1096/fj.202202169rr · Cited by 5

Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner

Chauvin, C., Radulovic, K., Boulard, O., Delacre, M., Waldschmitt, N., Régnier, P., Legris, G., Bouchez, C., Sleimi, M.-Y., Rosenstiel, P. C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1252979 · Cited by 5

Enteric glia regulate Paneth cell secretion and intestinal microbial ecologyPreprint

Prochera, A., Muppirala, A. N., Kuziel, G. A., Soualhi, S., Shepherd, A., Sun, L., Issac, B., Rosenberg, H. J., Karim, F., Perez, K., et al. (2024) · eLife · doi:10.7554/elife.97144 · Cited by 6

Repurposing liraglutide to the management of DSS-induced colitis: a potential for promoting autophagy

Saadoun, A. A., Abdelsattar, A. H., Elsaid, A. H., Abdelaleam, E. A., Abdelkader, H. K., Ibrahim, H. M., Saad, M., Ellawi, M. S., El-Said, R., Maghrabia, A. E., et al. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04339-w · Cited by 4

Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease

Erkert, L., Haag, L.-M., & Becker, C. (2026) · Seminars in Immunopathology · doi:10.1007/s00281-026-01068-x · Cited by 5

Interaction between microRNA-195 and HuR regulates Paneth cell function in the intestinal epithelium by altering SOX9 translation

Kwon, M. S., Chung, H. K., Xiao, L., Yu, T., Sharma, S., Cairns, C. A., Chen, T., Chae, S., Turner, D. J., & Wang, J. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00325.2024 · Cited by 4

Enzymatic hydrolysate of porphyra enhances the intestinal mucosal functions in obese mice

Li, C., Cheng, X., Cao, W., Wang, Y., Xue, C., & Tang, Q. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14175 · Cited by 4

BCL2 regulates antibacterial autophagy in the intestinal epithelium

Li, Y., Bel, S., Benjamin, J. L., Ruhn, K. A., Hassell, B., Behrendt, C. L., Kuang, Z., & Hooper, L. V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2410205121 · Cited by 4

Inhibition of Atg7 in intestinal epithelial cells drives resistance against Citrobacter rodentium

Cune, D., Pitasi, C. L., Rubiola, A., Trinath, J., Simula, L., Boucher, C., Fortun, A., Adoux, L., Letourneur, F., Saintpierre, B., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07422-5 · Cited by 4

Intracellular and intercellular crosstalk between exosomes and autophagy

Li, Q., Chen, S., Yin, Y., Han, M., Shi, H., Gong, Y. L., Duan, X., Wang, Y., Guo, Q., Duan, Y., et al. (2025) · The Innovation Life · doi:10.59717/j.xinn-life.2025.100132 · Cited by 4

5′-tiRNA-Lys maintains intestinal epithelial homeostasis by EWSR1-dependent suppression of miR-125a and autophagy activation

Xu, N., Huang, J., Wang, Y., Liu, Y., Jiang, Y., Zhou, W. M., Sheng, J., & Zhang, L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025074 · Cited by 4

Bioartificial gut—current state of small intestinal tissue engineering

Däullary, T., Fey, C., Berger, C., Metzger, M., & Zdzieblo, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102906-0.00025-8 · Cited by 4

Identification and characterization of an antimicrobial peptide, lysozyme, from Suncus murinus

Takemi, S., Ojima, S., Tanaka, T., Sakai, T., & Sakata, I. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-02991-2 · Cited by 4

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagyPreprint

Jones, E. J., Matthews, Z. J., Gul, L., Sudhakar, P., Treveil, A., Divekar, D., Buck, J., Wrzesinski, T., Jefferson, M., Armstrong, S. D., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/410027 · Cited by 4

Activated STING1 rides the Rafeesome

Han, Y., Zheng, J., & Ge, L. (2023) · Autophagy · doi:10.1080/15548627.2023.2240154 · Cited by 4

Elucidating early intestinal stem cell response to bacterial infectionPreprint

Lebon, S., Davidzohn, N., Menachem, A. H., Katz, A., Wigoda, N., Rotkopf, R., Dadosh, T., Levin‐Zaidman, S., Dezorella, N., Blumberger, N., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.15.613128 · Cited by 4

Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity

Akoh-Arrey, T., & Brooks, J. F. (2026) · Current Opinion in Immunology · doi:10.1016/j.coi.2026.102738 · Cited by 3

An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection

Lebon, S., Menachem, A. H., Davidzohn, N., Katz, A., Wigoda, N., Braun, T., Yahalomi, D., Rotkopf, R., Holiar, V. V., Dadosh, T., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02514-6 · Cited by 4

Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease

Nighot, P. K., Stine, J. G., & Clarke, K. (2025) · Gastro Hep Advances · doi:10.1016/j.gastha.2025.100654 · Cited by 3

Short histological kaleidoscope – recent findings in histology. Part III

Constantin, A.-M., Mihu, C. M., Boşca, A. B., Melincovici, C. S., Mărginean, M. V., Jianu, M. E., Onofrei, M. M., Micu, C. M., Alexandru, B.-C., Suflețel, R. T., et al. (2023) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.64.2.01 · Cited by 4

Paneth Cell Hyperplasia and Metaplasia in Hirschsprung-associated Enterocolitis in An Aganglionosis Rat Model

Budianto, I. R., Firmansyah, A., Moenadjat, Y., Jusuf, A. A., & Soetikno, V. (2022) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v14i4.2007 · Cited by 3

Following cell type transitions in space and time by combining live-cell tracking and endpoint cell identity in intestinal organoidsPreprint

Zheng, X., Betjes, M. A., Goos, Y. J., Huelsz‐Prince, G., Clevers, H. C., van Zon, J. S., & Tans, S. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.27.497728 · Cited by 3

A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expressionPreprint

Knop, M., Treitz, C., Bettendorf, S., Bossen, J., von Frieling, J., Doms, S., Bruchhaus, I., Kühnlein, R. P., Baines, J. F., Tholey, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.02.543385 · Cited by 3

Foiling bad bugs' sneaky tricks

Hurtley, S. M. (2017) · Science · doi:10.1126/science.357.6355.1011-b

Secretory autophagy holds the key to lysozyme secretion during bacterial infection of the intestine

Delorme‐Axford, E., & Klionsky, D. J. (2017) · Autophagy · doi:10.1080/15548627.2017.1401425 · Cited by 28

Secretory autophagy of lysozyme in Paneth cells

Bel, S., & Hooper, L. V. (2018) · Autophagy · doi:10.1080/15548627.2018.1430462 · Cited by 43

A new way out for lysozyme

Starling, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.98 · Cited by 6

Autophagy counters LPS-mediated suppression of lysozyme

Singh, S., & Lin, H. C. (2017) · Innate Immunity · doi:10.1177/1753425917721630 · Cited by 13