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Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
Open accessAbstract
Foiling bad bugs' sneaky tricks: Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel et al. show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense. Science , this issue p. 1047 ; see also p. 976
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Metadata
- Authors
- Bel, S., Pendse, M., Wang, Y., Li, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J., & Hooper, L. V.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Broad Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Hooper, Lora V.
- ORCID
- Venue
- Science
- Published
- 2017-09-08
- Volume
- 357
- Issue
- 6355
- Pages
- 1047-1052
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5702267
- OpenAlex
- W2740220090
- Cited by
- 396
- References
- 27
- Citations by year
- 2026: 28 · 2025: 46 · 2024: 42 · 2023: 43 · 2022: 70 · 2021: 41 · 2020: 37 · 2019: 46 · 2018: 30 · 2017: 13
- FWCI
- 27.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (award310630, DK070855, award339066, AI118807, award339067, AI128151)
- Howard Hughes Medical Institute (award310633, N/A)
- Welch Foundation (award310632, I-1874, award339068, I-1858)
- Burroughs Wellcome Foundation (award310631, 1007035)
- Gruss-Lipper Foundation (award310634, N/A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Paneth cells, lysozyme secretion, secretory autophagy, intestinal epithelial cells, bacterial intestinal infections, endoplasmic reticulum stress, ILC3, antimicrobial proteins, innate immune response
- MeSH terms
- Autophagy-Related Proteins, Animals, Autophagy, Carrier Proteins, Crohn Disease, Mice, Inbred C57BL, Microtubule-Associated Proteins, Muramidase, Mutation, Salmonella Infections, Salmonella enterica, Paneth Cells, Mice, Endoplasmic Reticulum Stress
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