The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Abstract
Mutation for microcephaly: Zika virus infections in humans have been known since 1947. Microcephaly and neuropathologies associated with Zika have only been reported recently, most prevalently in the Americas. Yuan et al. investigated recent stable mutations in the virus genome and engineered them into a low-virulence ancestral strain (see the Perspective by Screaton and Mongkolsapaya). A single amino acid substitution (serine to asparagine, S139N) in the viral precursor membrane protein exacerbated symptoms in pregnant mice. The reverse mutation (N139S) was less virulent. The S139N mutation arose in 2013 in French Polynesia before the virus jumped to Brazil in 2015. In vitro, this amino acid change made the virus more infectious for mouse and human neural progenitor cells and promoted apoptosis. The terrible sequelae of infection during pregnancy could thus be the result of a simple viral mutation. Science , this issue p. 933 ; see also p. 863
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Self-citationThe Zika Virus Epidemic in Brazil: From Discovery to Future Implications
Lowe, R., Barcellos, C., Brasil, P., Cruz, O., Honório, N., Kuper, H., & Carvalho, M. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15010096 · Cited by 398
The emergence of Zika virus and its new clinical syndromes
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Biochemistry and Molecular Biology of Flaviviruses
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Metadata
- Authors
- Yuan, L., Huang, X.-Y., Liu, Z.-Y., Zhang, F., Zhu, X.-L., Yu, J.-Y., Ji, X., Xu, Y.-P., Li, G., Li, C., Wang, H.-J., Deng, Y.-Q., Wu, M., Cheng, M.-L., Ye, Q., Xie, D.-Y., Li, X.-F., Wang, X., Shi, W., Hu, B., Shi, P.-Y., Xu, Z., & Qin, C.-F.
- Venue
- Science
- Published
- 2017-11-17
- Volume
- 358
- Issue
- 6365
- Pages
- 933-936
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2760364797
- Cited by
- 473
- References
- 45
- FWCI
- 61.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuan, L., Huang, X.-Y., Liu, Z.-Y., Zhang, F., Zhu, X.-L., Yu, J.-Y., Ji, X., Xu, Y.-P., Li, G., Li, C., Wang, H.-J., Deng, Y.-Q., Wu, M., Cheng, M.-L., Ye, Q., Xie, D.-Y., Li, X.-F., Wang, X., Shi, W., . . . Qin, C.-F. (2017). A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Science. https://doi.org/10.1126/science.aam7120
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
