The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress
Open accessAbstract
The mitoCPR unclogs mitochondria: The import of proteins into mitochondria is essential for cell viability. How cells respond when mitochondrial protein import is impaired is poorly understood. Weidberg and Amon showed that upon mitochondrial import stress, yeast cells mounted a response known as the mitoCPR. mitoCPR was activated when mitochondrial protein import was impaired and unimported precursors accumulated on the organelle's surface. mitoCPR restored mitochondrial functions by clearing stalled proteins from the import channels. It did this by inducing expression of Cis1, which recruited the adenosine triphosphatase Msp1 to import channels to remove unimported precursors and target them for degradation by the proteasome. Science , this issue p. eaan4146
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Global analysis of protein localization in budding yeast
Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248 · cited 1×
“Cis1 associates withmitochondria in highthroughput localization studies (36), which prompted us to investigate whether the protein played a role in protecting mitochondria during import stress.”
BackgroundYoule, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273
A nuclear receptor-like pathway regulating multidrug resistance in fungi
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Laloraya, S., Gambill, B. D., & Craig, E. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6481 · Cited by 165
Cited by
Mitochondrial proteins: from biogenesis to functional networks
Pfanner, N., Warscheid, B., & Wiedemann, N. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0092-0 · Cited by 1,028
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
Mechanisms and regulation of protein synthesis in mitochondria
Kummer, E., & Ban, N. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00332-2 · Cited by 349
Mitochondrial degradation: Mitophagy and beyond
Uoselis, L., Nguyen, T. N., & Lazarou, M. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.08.021 · Cited by 270
Mitochondria-Striking a balance between host and endosymbiont
Youle, R. J. (2019) · Science · doi:10.1126/science.aaw9855 · Cited by 199
Metadata
- Authors
- Weidberg, H., & Amon, A.
- Venue
- Science
- Published
- 2018-04-13
- Volume
- 360
- Issue
- 6385
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2796883998
- Cited by
- 343
- References
- 5
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
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