The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Single-stranded DNA and RNA origami
Open accessAbstract
Large origami from a single strand: Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers. The use of single strands also enables in vitro synthesis of these structures. Science , this issue p. eaao2648
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“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
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“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
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Cites
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,474 · cited 8×
“Despite its fundamental importance and practical desirability, as well as the aforementioned promising early efforts (3, 41–45), it remains challenging to develop a general strategy for the design and synthesis of an ssDNA or ssRNA that can fold into a user-prescribed complex, arbitrary shape [for example, comparable…”
BackgroundMethodInfluentialDesign and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857 · cited 2×
“A typical PCR reaction was as follows: (1) Initial denaturation at 98°C for 30 s; (2) 25 to 35 cycles of 10 s at 98°C (strand separation stage), 30 s at 65°C (annealing stage), and 1 min at 72°C (polymerase extension stage); (3) final extension for 10 min at 72°C; (4) hold at 4°C after reaction.”
MethodSelf-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,617 · cited 2×
“However, whereas multikilobase, megadalton-size discrete DNA nanostructures have been demonstrated [for example, via scaffolded origami (4, 8) and DNA bricks (14, 15)], synthetic RNA nanostructures remain comparatively simple: The largest discrete structure demonstrated is the aforementioned 660-nt ssRNA tile (44).”
BackgroundDNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
Kuzyk, A., Schreiber, R., Fan, Z., Pardatscher, G., Roller, E.-M., Högele, A., Simmel, F. C., Govorov, A. O., & Liedl, T. (2012) · Nature · doi:10.1038/nature10889 · Cited by 2,235
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,187
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B. O., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,650
Synthesis from DNA of a molecule with the connectivity of a cube
Chen, J., & Seeman, N. C. (1991) · Nature · doi:10.1038/350631a0 · Cited by 1,394 · cited 3×
“More formally, previous scaffolded origami work and the DNA brick work demonstrate the construction of a size n object using O(n) number of components; the unimolecular ssOrigami demonstrates the construction of a size n object using one component; the two-strand case represents its construction using O(1) components;…”
MethodFolding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,361
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
He, Y., Ye, T., Su, M., Zhang, C., Ribbe, A. E., Jiang, W., & Mao, C. (2008) · Nature · doi:10.1038/nature06597 · Cited by 1,326
Three-Dimensional Structures Self-Assembled from DNA Bricks
Ke, Y., Ong, L. L., Shih, W. M., & Yin, P. (2012) · Science · doi:10.1126/science.1227268 · Cited by 1,249
Self-citation
Research works printed but not linked: 1
- W. B. R. Lickorish An Introduction to Knot Theory (Springer Science and Business Media 2012) vol. 175.
Cited by
Sorted by citations
Dey, S., Fan, C., Gothelf, K. V., Li, J., Lin, C., Liu, L., Liu, N., Nijenhuis, M. A. D., Saccà, B., Simmel, F. C., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-020-00009-8 · Cited by 815
Self-citationBoeynaems, S., Holehouse, A. S., Weinhardt, V., Kovács, D., Lindt, J. V., Larabell, C. A., Bosch, L. V. D., Das, R., Tompa, P., Pappu, R. V., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821038116 · Cited by 460
Recent Advances in DNA Origami-Engineered Nanomaterials and Applications
Zhan, P., Peil, A., Jiang, Q., Wang, D., Mousavi, S., Xiong, Q., Shen, Q., Shang, Y., Ding, B., Lin, C., et al. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00028 · Cited by 383
Concept and Development of Framework Nucleic Acids
Ge, Z., Gu, H., Li, Q., & Fan, C. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10529 · Cited by 307
Peng, R., Zheng, X., Lyu, Y., Xu, L., Zhang, X., Ke, G., Liu, Q., You, C., Huan, S., & Tan, W. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04319 · Cited by 291
Metadata
- Authors
- Han, D., Qi, X., Myhrvold, C., Wang, B., Dai, M., Jiang, S., Bates, M., Liu, Y., An, B., Zhang, F., Yan, H., & Yin, P.
- Affiliations
- Harvard University (US)
- Arizona State University (US)
- University of Science and Technology of China (CN)
- Autodesk (United States) (US)
- Corresponding author
- Han, Dongran
- Qi, Xiaodong
- An, Byoungkwon
- Zhang, Fei
- Yan, Hao
- Yin, Peng
- ORCID
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6384012
- OpenAlex
- W2775235705
- Cited by
- 300
- References
- 67
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 31 · 2023: 30 · 2022: 41 · 2021: 39 · 2020: 48 · 2019: 24 · 2018: 29
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- National Science Foundation (award355762, 1360635, award355763, 1563799, award355764, 1334109)
- Office of Naval Research (award355757, N000141010827, award355758, N000141310593, award355759, N000141410610, award355761, N000141512689)
- China Scholarship Council (award355765, 201506340048)
- Army Research Office (award355760, W911NF1210238)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Keywords
- DNA origami, RNA origami, single-stranded DNA, single-stranded RNA, nucleic acid nanostructures, self-assembly, in vitro replication, in vivo replication, bottom-up nanotechnology
- MeSH terms
- DNA Replication, DNA, Single-Stranded, Escherichia coli, Nucleotides, RNA, Nanotechnology, Nanostructures, RNA Folding
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