The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Single-stranded DNA and RNA origami
Open accessAbstract
Large origami from a single strand: Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers. The use of single strands also enables in vitro synthesis of these structures. Science , this issue p. eaao2648
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
In the citing paper
“As three-dimensional nucleic acid nanostructures have also successfully been produced inside cells,154 there is potentially important synergy between in vitro/in vivo DNA nanotechnology and data storage, which remains, as of yet, unexplored.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [154]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,474 · cited 8×
“Despite its fundamental importance and practical desirability, as well as the aforementioned promising early efforts (3, 41–45), it remains challenging to develop a general strategy for the design and synthesis of an ssDNA or ssRNA that can fold into a user-prescribed complex, arbitrary shape [for example, comparable…”
BackgroundMethodInfluentialDesign and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857 · cited 2×
“A typical PCR reaction was as follows: (1) Initial denaturation at 98°C for 30 s; (2) 25 to 35 cycles of 10 s at 98°C (strand separation stage), 30 s at 65°C (annealing stage), and 1 min at 72°C (polymerase extension stage); (3) final extension for 10 min at 72°C; (4) hold at 4°C after reaction.”
MethodSelf-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,617 · cited 2×
“However, whereas multikilobase, megadalton-size discrete DNA nanostructures have been demonstrated [for example, via scaffolded origami (4, 8) and DNA bricks (14, 15)], synthetic RNA nanostructures remain comparatively simple: The largest discrete structure demonstrated is the aforementioned 660-nt ssRNA tile (44).”
BackgroundDNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
Kuzyk, A., Schreiber, R., Fan, Z., Pardatscher, G., Roller, E.-M., Högele, A., Simmel, F. C., Govorov, A. O., & Liedl, T. (2012) · Nature · doi:10.1038/nature10889 · Cited by 2,235
A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
Douglas, S. M., Bachelet, I., & Church, G. M. (2012) · Science · doi:10.1126/science.1214081 · Cited by 2,187
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B. O., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,650
Synthesis from DNA of a molecule with the connectivity of a cube
Chen, J., & Seeman, N. C. (1991) · Nature · doi:10.1038/350631a0 · Cited by 1,394 · cited 3×
“More formally, previous scaffolded origami work and the DNA brick work demonstrate the construction of a size n object using O(n) number of components; the unimolecular ssOrigami demonstrates the construction of a size n object using one component; the two-strand case represents its construction using O(1) components;…”
MethodFolding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,361
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
He, Y., Ye, T., Su, M., Zhang, C., Ribbe, A. E., Jiang, W., & Mao, C. (2008) · Nature · doi:10.1038/nature06597 · Cited by 1,326
Three-Dimensional Structures Self-Assembled from DNA Bricks
Ke, Y., Ong, L. L., Shih, W. M., & Yin, P. (2012) · Science · doi:10.1126/science.1227268 · Cited by 1,249
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- W. B. R. Lickorish An Introduction to Knot Theory (Springer Science and Business Media 2012) vol. 175.
Cited by
Sorted by citations
Dey, S., Fan, C., Gothelf, K. V., Li, J., Lin, C., Liu, L., Liu, N., Nijenhuis, M. A. D., Saccà, B., Simmel, F. C., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-020-00009-8 · Cited by 815
Self-citationBoeynaems, S., Holehouse, A. S., Weinhardt, V., Kovács, D., Lindt, J. V., Larabell, C. A., Bosch, L. V. D., Das, R., Tompa, P., Pappu, R. V., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821038116 · Cited by 460
Recent Advances in DNA Origami-Engineered Nanomaterials and Applications
Zhan, P., Peil, A., Jiang, Q., Wang, D., Mousavi, S., Xiong, Q., Shen, Q., Shang, Y., Ding, B., Lin, C., et al. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00028 · Cited by 383
Concept and Development of Framework Nucleic Acids
Ge, Z., Gu, H., Li, Q., & Fan, C. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10529 · Cited by 307
Peng, R., Zheng, X., Lyu, Y., Xu, L., Zhang, X., Ke, G., Liu, Q., You, C., Huan, S., & Tan, W. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04319 · Cited by 291
Building machines with DNA molecules
Ramezani, H., & Dietz, H. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0175-6 · Cited by 293
Nucleic Acid Tests for Clinical Translation
Li, M., Yin, F., Song, L., Mao, X., Li, F., Fan, C., Zuo, X., & Xia, Q. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00241 · Cited by 274
SELFIES and the future of molecular string representations
Krenn, M., Ai, Q., Barthel, S., Carson, N., Frei, A., Frey, N. C., Friederich, P., Gaudin, T., Gayle, A. A., Jablonka, K. M., et al. (2022) · Patterns · doi:10.1016/j.patter.2022.100588 · Cited by 295
DNA Origami Route for Nanophotonics
Kuzyk, A., Jungmann, R., Acuna, G. P., & Liu, N. (2018) · ACS Photonics · doi:10.1021/acsphotonics.7b01580 · Cited by 244
Emerging Approaches to DNA Data Storage: Challenges and Prospects
Doricchi, A., Platnich, C. M., Gimpel, A., Horn, F., Earle, M., Lanzavecchia, G., Cortajarena, A. L., Liz-Marzán, L. M., Liu, N., Heckel, R., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06748 · Cited by 235
Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers
Krissanaprasit, A., Key, C. M., Pontula, S., & LaBean, T. H. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01332 · Cited by 187
Poppleton, E., Bohlin, J., Matthies, M., Sharma, S., Zhang, F., & Šulc, P. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa417 · Cited by 182
Self-citationYao, G., Zhang, F., Wang, F., Peng, T., Liu, H., Poppleton, E., Šulc, P., Jiang, S., Liu, L., Gong, C., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-0539-8 · Cited by 177
Self-citationDesigner DNA nanostructures for therapeutics
Jiang, S., Ge, Z., Mou, S., Yan, H., & Fan, C. (2020) · Chem · doi:10.1016/j.chempr.2020.10.025 · Cited by 174
Self-citationZhao, Y., Zuo, X., Li, Q., Chen, F., Chen, Y.-R., Deng, J., Han, D., Hao, C., Huang, F., Huang, Y., et al. (2020) · Science China Chemistry · doi:10.1007/s11426-020-9864-7 · Cited by 167
Self-citationDNA nanotechnology-empowered nanoscopic imaging of biomolecules
Li, F., Li, J., Dong, B., Wang, F., Fan, C., & Zuo, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01281e · Cited by 142
Chen, Y., Ke, G., Ma, Y., Zhu, Z., Liu, M., Liu, Y., Yan, H., & Yang, C. J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b05429 · Cited by 141
Self-citationZhang, J., Lin, B., Wu, L., Huang, M., Li, X., Zhang, H., Song, J. T., Wang, W., Zhao, G., Song, Y., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005974 · Cited by 132
In vivo production of RNA nanostructures via programmed folding of single-stranded RNAs
Li, M., Zheng, M., Wu, S., Tian, C., Liu, D., Weizmann, Y., Jiang, W., Wang, G., & Mao, C. (2018) · Nature Communications · doi:10.1038/s41467-018-04652-4 · Cited by 132
Recent advances in DNA nanotechnology
Chidchob, P., & Sleiman, H. F. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.04.012 · Cited by 124
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds
Geary, C. W., Grossi, G., McRae, E. K. S., Rothemund, P. W. K., & Andersen, E. S. (2021) · Nature Chemistry · doi:10.1038/s41557-021-00679-1 · Cited by 124
“…future be improved by extending the library of functional motifs and by supporting alternative architectures such as parallel crossover RNA origami 9 and wireframe RNA origami 8 as well as allowing physical simulation of the structures to address strain-induced distortions (using, for example,…”
Rationally designed DNA-based nanocarriers
Jiang, Q., Zhao, S., Liu, J., Song, L., Wang, Z., & Ding, B. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.003 · Cited by 105
Wang, G., Yang, H., Yan, Z., Ulu, N. G., Tao, Y., Gu, J., Kara, L. B., & Yao, L. (2018) · ACM Symposium on User Interface Software and Technology (UIST) · doi:10.1145/3242587.3242625 · Cited by 106
Bioapplications of DNA nanotechnology at the solid–liquid interface
Wang, W., Yu, S., Huang, S., Bi, S., Han, H., Zhang, J., Lu, Y., & Zhu, J. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00402a · Cited by 103
Origami Biosystems: 3D Assembly Methods for Biomedical Applications
Quiñones, V. A. B., Zhu, H. Y., Solovev, A. A., Mei, Y., & Gracias, D. H. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800230 · Cited by 98
DNA origami-based protein networks: from basic construction to emerging applications
Kong, G., Xiong, M., Liu, L., Hu, L., Meng, H., Ke, G., Zhang, X., & Tan, W. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00255k · Cited by 95
Paranemic Crossover DNA: There and Back Again
Wang, X., Chandrasekaran, A. R., Shen, Z., Ohayon, Y. P., Wang, T., Kizer, M. E., Sha, R., Mao, C., Yan, H., Zhang, X., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00207 · Cited by 97
Self-citationKe, Y., Huang, S., Ghalandari, B., Li, S., Warden, A. R., Dang, J., Kang, L., Zhang, Y., Wang, Y., Sun, Y., et al. (2021) · Advanced Science · doi:10.1002/advs.202003611 · Cited by 90
Chandrasekaran, A. R., Vilcapoma, J., Dey, P., Wong-Deyrup, S. W., Dey, B. K., & Halvorsen, K. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c02211 · Cited by 92
Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering
Fan, H. B., Jiang, S., Lan, X., Narayanan, R. P., Šulc, P., Zhang, F., Liu, Y., & Yan, H. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b07180 · Cited by 87
Self-citationRNA Origami Nanostructures for Potent and Safe Anticancer Immunotherapy
Qi, X., Liu, X., Matiski, L., del Villar, R. R., Yip, T., Zhang, F., Sokalingam, S., Jiang, S., Liu, L., Yan, H., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c00602 · Cited by 84
Self-citationA DNA Origami‐Based Gene Editing System for Efficient Gene Therapy in Vivo
Tang, W., Tong, T., Wang, H., Lu, X., Yang, C., Wu, Y., Wang, Y., Liu, J., & Ding, B. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202315093 · Cited by 89
The Growing Development of DNA Nanostructures for Potential Healthcare‐Related Applications
Mathur, D., & Medintz, I. L. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801546 · Cited by 85
DNA origami signposts for identifying proteins on cell membranes by electron cryotomography
Silvester, E., Vollmer, B., Pražák, V., Vasishtan, D., Machala, E. A., Whittle, C., Black, S. S., Bath, J., Turberfield, A. J., Grünewald, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.033 · Cited by 84
Kim, J., Ashwanikumar, N., Patel, S., & Sahay, G. (2019) · Theranostics · doi:10.7150/thno.33921 · Cited by 79
“Recent studies showed single-stranded RNAs assembled into various 2D and 3D structures (Figure 5B, C) [85,86].”
BackgroundGenetically Encoded DNA Origami for Gene Therapy In Vivo
Wu, X., Yang, C., Wang, H., Lu, X., Shang, Y., Liu, Q. L., Fan, J., Liu, J., & Ding, B. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c02756 · Cited by 76
Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures
Liu, D., Geary, C. W., Chen, G., Shao, Y., Li, M., Mao, C., Andersen, E. S., Piccirilli, J. A., Rothemund, P. W. K., & Weizmann, Y. (2020) · Nature Chemistry · doi:10.1038/s41557-019-0406-7 · Cited by 76
He, Z., Shi, K., Li, J., & Chao, J. (2023) · iScience · doi:10.1016/j.isci.2023.106638 · Cited by 72
“In 2017, researchers proposed a framework for assembling an individual DNA or RNA strand into a complex but unknotted single-stranded origami (ssOrigami) structure.(2) This ssOrigami does not involve auxiliary strands and can be assembled into diverse spatially compact structures.”
BackgroundDelivery of therapeutic oligonucleotides in nanoscale
Wu, L., Zhou, W., Lin, L., Chen, A., Feng, J. C., Qu, X., Zhang, H., & Yue, J. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.038 · Cited by 72
“Strategies developed for fabricating DNA/ RNA nanoassembly mainly include DNA origami [296], single-stranded tile (SST) DNA nanostructures [297], and single-stranded (ss) DNA/RNA origami [298].”
BackgroundProgramming Switchable Transcription of Topologically Constrained DNA
Jiao, K., Zhu, B., Guo, L., Zhou, H., Wang, F., Zhang, X., Shi, J., Li, Q., Wang, L., Li, J., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c01962 · Cited by 69
Single-Stranded DNA-Encoded Gold Nanoparticle Clusters as Programmable Enzyme Equivalents
Chen, X., Wang, Y., Dai, X., Ding, L., Chen, J., Yao, G., Liu, X., Luo, S., Shi, J., Wang, L., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.1c13116 · Cited by 69
Ma, D., Li, Y., Wu, K., Yan, Z., Tang, A. A., Chaudhary, S., Ticktin, Z. M., Alcántar‐Fernández, J., Moreno-Camacho, J. L., Campos‐Romero, A., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00857-7 · Cited by 67
Mao, X., Liu, M., Li, Q., Fan, C., & Zuo, X. (2022) · JACS Au · doi:10.1021/jacsau.2c00292 · Cited by 69
DNA Catalyzed Efficient Production of Single-Stranded DNA Nanostructures
Jia, Y., Chen, L., Liu, J., Li, W., & Gu, H. (2019) · Chem · doi:10.1016/j.chempr.2020.12.001 · Cited by 61
Programming molecular topologies from single-stranded nucleic acids
Qi, X., Zhang, F., Su, Z., Jiang, S., Han, D., Ding, B., Liu, Y., Chiu, W., Yin, P., & Yan, H. (2018) · Nature Communications · doi:10.1038/s41467-018-07039-7 · Cited by 69
Self-citationNanopore microscope identifies RNA isoforms with structural colours
Bošković, F., & Keyser, U. F. (2022) · Nature Chemistry · doi:10.1038/s41557-022-01037-5 · Cited by 57
Comparing proteins and nucleic acids for next-generation biomolecular engineering
Pugh, G., Burns, J. R., & Howorka, S. (2018) · Nature Reviews Chemistry · doi:10.1038/s41570-018-0015-9 · Cited by 59
Programming Structured DNA Assemblies to Probe Biophysical Processes
Wamhoff, E., Banal, J. L., Bricker, W. P., Shepherd, T. R., Parsons, M. F., Veneziano, R., Stone, M. B., Jun, H., Wang, X., & Bathe, M. (2019) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-052118-115259 · Cited by 59
Nanofabrication approaches for functional three-dimensional architectures
Zhao, H., Lee, Y., Han, M., Sharma, B. K., Chen, X., Ahn, J., & Rogers, J. A. (2019) · Nano Today · doi:10.1016/j.nantod.2019.100825 · Cited by 61
Adenita: interactive 3D modelling and visualization of DNA nanostructures
de Llano, E., Miao, H., Ahmadi, Y., Wilson, A. J., Beeby, M., Viola, I., & Barišić, I. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa593 · Cited by 58
“For single-stranded DNA/RNA origami (33), we would need to adapt the colour coding as we currently depict only one colour per single strand.”
MethodDNA‐Based Nanofabrication for Nanoelectronics
Hui, L., Bai, R., & Liu, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202112331 · Cited by 55
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification
Baker, Y. R., Yuan, L., Chen, J., Belle, R., Carlisle, R. C., El-Sagheer, A. H., & Brown, T. P. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab720 · Cited by 54
Synthesis of DNA Origami Scaffolds: Current and Emerging Strategies
Bush, J., Singh, S., Vargas, M., Oktay, E., Hu, C.-H., & Veneziano, R. (2020) · Molecules · doi:10.3390/molecules25153386 · Cited by 65
“[89] prepared self-complementary ssDNA scaffolds with sizes ranging from 966 to 10,682 nts for staple-free DNA origami assembly.”
BackgroundLoescher, S., Groeer, S., & Walther, A. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801700 · Cited by 54
Artificial Bioaugmentation of Biomacromolecules and Living Organisms for Biomedical Applications
Cao, J., Zaremba, O. T., Lei, Q., Ploetz, E., Wuttke, S., & Zhu, W. (2021) · ACS Nano · doi:10.1021/acsnano.0c10144 · Cited by 53
Nucleic acid nanotechnology for cancer treatment
Jin, J., Kim, G., Hwang, J., Han, K. H., Kwak, M., & Lee, P. C.-W. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188377 · Cited by 49
Li, X., Bhullar, A. S., Binzel, D. W., & Guo, P. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114316 · Cited by 47
“Besides small RNA nanoparticle s constructed by bottom-up assembly, large RNA nanoparticles are also available using RNA origami (up to 6000 nt) and RCT (100 – 2000 nm) method [102, 103].”
Method3D RNA-scaffolded wireframe origami
Parsons, M. F., Allan, M. F., Li, S., Shepherd, T. R., Ratanalert, S., Zhang, K., Pullen, K. M., Chiu, W., Rouskin, S., & Bathe, M. (2023) · Nature Communications · doi:10.1038/s41467-023-36156-1 · Cited by 50
Versatile kit of robust nanoshapes self-assembling from RNA and DNA modules
Monferrer, A., Zhang, D., Lushnikov, A. J., & Hermann, T. (2019) · Nature Communications · doi:10.1038/s41467-019-08521-6 · Cited by 46
Aptamer-Functionalized DNA Nanostructures for Biological Applications
Fu, X., Peng, F., Lee, J., Yang, Q., Zhang, F., Xiong, M., Kong, G., Meng, H., Ke, G., & Zhang, X. (2020) · Topics in Current Chemistry · doi:10.1007/s41061-020-0283-y · Cited by 45
Self-citationProgramming Dynamic Assembly of Viral Proteins with DNA Origami
Zhou, K., Zhou, Y., Pan, V., Wang, Q., & Ke, Y. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b13773 · Cited by 45
Zhou, Y., Qi, X., Liu, Y., Zhang, F., & Yan, H. (2019) · ChemBioChem · doi:10.1002/cbic.201900265 · Cited by 42
Self-citationNucleic Acid‐based Enzyme Cascades—Current Trends and Future Perspectives
Kröll, S., & Niemeyer, C. M. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202314452 · Cited by 43
Chemically modified DNA nanostructures for drug delivery
Wang, Y., Lu, X., Wu, X., Li, Y., Tang, W., Yang, C., Liu, J., & Ding, B. (2022) · The Innovation · doi:10.1016/j.xinn.2022.100217 · Cited by 42
Remote Photothermal Control of DNA Origami Assembly in Cellular Environments
Zhang, C., Jing, X., Guo, L., Cui, C., Hou, X., Zuo, T., Liu, J., Shi, J., Liu, X., Zuo, X., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01821 · Cited by 42
Local mechanical description of an elastic fold
Jules, T., Lechenault, F., & Adda-Bedia, M. (2019) · Soft Matter · doi:10.1039/c8sm01791c · Cited by 40
RNA nanotechnology in synthetic biology
Kim, J., & Franco, E. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.12.016 · Cited by 42
Bioorthogonal chemistry-based RNA labeling technologies: evolution and current state
George, J. T., & Srivatsan, S. G. (2020) · Chemical Communications · doi:10.1039/d0cc05228k · Cited by 41
Sapp, V., Aguirre, A., Mainkar, G., Ding, J., Adler, E., Liao, R., Sharma, S., & Jain, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-92988-1 · Cited by 40
Gillams, R. J., & Jia, T. Z. (2018) · Life · doi:10.3390/life8020010 · Cited by 40
RNA nanostructures and scaffolds for biotechnology applications
Ohno, H., Akamine, S., & Saito, H. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.11.006 · Cited by 41
DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions
Fu, J., Wang, Z., Liang, X., Oh, S. W., Iago-Mcrae, E. S., & Zhang, T. (2020) · Topics in Current Chemistry · doi:10.1007/s41061-020-0299-3 · Cited by 38
“Recent progress has been made to scale up DNA assemblies in terms of size and quantity [30] and to fold nanostructures with single-stranded nucleic acids [31].”
BackgroundActive Nuclear Import of Mammalian Cell-Expressible DNA Origami
Liedl, A., Griessing, J. M., Kretzmann, J. A., & Dietz, H. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12733 · Cited by 37
“…Since programmable self-assembly with DNA or RNA origami enables the fabrication of complex three-dimensional objects from DNA or RNA in a user-defined manner, 5 − 8 these approaches could also enable delivering genetic instructions in more complex ways and with additional functionalities to cells.”
RNA origami: design, simulation and application
Poppleton, E., Urbanek, N., Chakraborty, T., Griffo, A., Monari, L., & Göpfrich, K. (2023) · RNA Biology · doi:10.1080/15476286.2023.2237719 · Cited by 37
“[50] method involved thermal annealing from 85°C over 18 hours in a high-Mg2+ buffer; however, it was later demonstrated that similar structures could be annealed from 65°C in 10 hours without Mg [51].”
BackgroundMethodInfluentialDesign, synthesis, and applications of DNA–macrocyclic host conjugates
Zhou, X., Pathak, P., & Jayawickramarajah, J. (2018) · Chemical Communications · doi:10.1039/c8cc06716c · Cited by 36
Nucleic acid and oligonucleotide delivery for activating innate immunity in cancer immunotherapy
Meng, F., Wang, J., & Yeo, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.045 · Cited by 36
Near-Atomic Fabrication with Nucleic Acids
Xia, K., Shen, J., Li, Q., Fan, C., & Gu, H. (2020) · ACS Nano · doi:10.1021/acsnano.9b09163 · Cited by 34
DNA Nanostructures in the Fight Against Infectious Diseases
Smith, D. M., & Keller, A. (2020) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000049 · Cited by 32
Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering
Gangrade, A., Stephanopoulos, N., & Bhatia, D. D. (2021) · Nanoscale · doi:10.1039/d1nr04475c · Cited by 33
Recent Advances in Self-Assembled DNA Nanostructures for Bioimaging
Yang, Q., Chang, X., Lee, J. Y., Olivera, T. R., Saji, M., Wisniewski, H., Kim, S., & Zhang, F. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00128 · Cited by 33
Self-citationLight‐Activated Assembly of DNA Origami into Dissipative Fibrils
Berg, W. R., Berengut, J. F., Bai, C., Wimberger, L., Lee, L. K., & Rizzuto, F. J. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202314458 · Cited by 31
Functional Applications of Nucleic Acid–Protein Hybrid Nanostructures
McCluskey, J. B., Clark, D. S., & Glover, D. J. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.02.007 · Cited by 33
Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution
Jia, T. Z., & Fraccia, T. P. (2020) · Crystals · doi:10.3390/cryst10110964 · Cited by 31
One-Pot Synthesis of Defined-Length ssDNA for Multiscaffold DNA Origami
Noteborn, W. E. M., Abendstein, L., & Sharp, T. H. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00644 · Cited by 30
Single-strand RPA for rapid and sensitive detection of SARS-CoV-2 RNAPreprint
Kim, Y., Yaseen, A., Kishi, J. Y., Fan, H. B., Saka, S. K., Sheng, K., Gopalkrishnan, N., Schaus, T. E., & Yin, P. (2020) · medRxiv · doi:10.1101/2020.08.17.20177006 · Cited by 29
Self-citationAdvances in intelligent DNA nanomachines for targeted cancer therapy
Chen, B., Lan, M., Wang, Y., & Guo, G. F. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.11.006 · Cited by 30
Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates
Majumder, S., Coupe, S., Fakhri, N., & Jain, A. (2025) · Nature Communications · doi:10.1038/s41467-025-59456-0 · Cited by 29
DNA Origami Post‐Processing by CRISPR‐Cas12a
Xiong, Q., Xie, C., Zhang, Z., Liu, L., Powell, J. T., Shen, Q., & Lin, C. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201915555 · Cited by 28
Krissanaprasit, A., Key, C. M., Froehlich, K. A., Pontula, S., Mihalko, E. P., Dupont, D. M., Andersen, E. S., Kjems, J., Brown, A. C., & LaBean, T. H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001826 · Cited by 31
Zhou, X., Lin, S., & Yan, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01449-y · Cited by 29
“ssDNA origami was also created by self-folding of a ssDNA strand that contained a partial complement to the desired shape via parallel crossover cohesion [140].”
Self-citationgRNAde: Geometric Deep Learning for 3D RNA inverse designPreprint
Joshi, C. K., Jamasb, A. R., Viñas, R., Harris, C., Mathis, S. V., Morehead, A., Anand, R., & Lió, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.31.587283 · Cited by 37
“…tools for RNA design primarily focus on secondary structure without considering 3D geometry (Churkin et al., 2018) or use non-learnt algorithms for aligning 3D RNA fragments (Han et al., 2017; Yesselman et al., 2019), which can be restrictive due to the hand-crafted nature of the heuristics used.”
Design of Transformable Hinged Ori-Block Dissected from Cylinders and Cones
Jia, G., Huang, H., Guo, H., Li, B., & Dai, J. S. (2021) · Journal of Mechanical Design · doi:10.1115/1.4050301 · Cited by 27
RNA Origami Functions as a Self-Adjuvanted Nanovaccine Platform for Cancer Immunotherapy
Yip, T., Qi, X., Yan, H., & Chang, Y. (2024) · ACS Nano · doi:10.1021/acsnano.3c07284 · Cited by 28
Self-citationDesign and Characterization of RNA Nanotubes
Stewart, J. M., Geary, C. W., & Franco, E. (2019) · ACS Nano · doi:10.1021/acsnano.8b09421 · Cited by 26
Seeding the Self-Assembly of DNA Origamis at Surfaces
Cao, H. H., Abel, G. R., Gu, Q., Gueorguieva, G.-A. V., Zhang, Y., Nanney, W. A., Provencio, E., & Ye, T. (2020) · ACS Nano · doi:10.1021/acsnano.9b09348 · Cited by 26
DNAs catalyzing DNA nanoconstruction
Li, Q., Tong, Z.-X., Cao, Y.-C., & Gu, H. (2021) · Chem · doi:10.1016/j.chempr.2021.08.008 · Cited by 26
DNA-templated programmable excitonic wires for micron-scale exciton transport
Zhou, X., Liu, H., Djutanta, F., Satyabola, D., Jiang, S., Qi, X., Yu, L., Lin, S., Hariadi, R. F., Liu, Y., et al. (2022) · Chem · doi:10.1016/j.chempr.2022.05.017 · Cited by 26
Self-citationPRNCR1: a long non-coding RNA with a pivotal oncogenic role in cancer
Bardhan, A., Banerjee, A., Basu, K., Pal, D. K., & Ghosh, A. (2021) · Human Genetics · doi:10.1007/s00439-021-02396-8 · Cited by 25
Multifunctional rolling circle transcription-based nanomaterials for advanced drug delivery
Ma, X., Zhang, Y., Huang, K., Zhu, L., & Xu, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122241 · Cited by 24
Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions
Subramanian, R. H., Smith, S. J., Alberstein, R. G., Bailey, J., Zhang, L., Giovanni Cardone, A., Suominen, L., Chami, M., Stahlberg, H., Baker, T. S., et al. (2018) · ACS Central Science · doi:10.1021/acscentsci.8b00745 · Cited by 24
Metadata
- Authors
- Han, D., Qi, X., Myhrvold, C., Wang, B., Dai, M., Jiang, S., Bates, M., Liu, Y., An, B., Zhang, F., Yan, H., & Yin, P.
- Affiliations
- Harvard University (US)
- Arizona State University (US)
- University of Science and Technology of China (CN)
- Autodesk (United States) (US)
- Corresponding author
- Han, Dongran
- Qi, Xiaodong
- An, Byoungkwon
- Zhang, Fei
- Yan, Hao
- Yin, Peng
- ORCID
- Venue
- Science
- Published
- 2017-12-15
- Volume
- 358
- Issue
- 6369
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6384012
- OpenAlex
- W2775235705
- Cited by
- 300
- References
- 67
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 31 · 2023: 30 · 2022: 41 · 2021: 39 · 2020: 48 · 2019: 24 · 2018: 29
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- Funders
- National Science Foundation (award355762, 1360635, award355763, 1563799, award355764, 1334109)
- Office of Naval Research (award355757, N000141010827, award355758, N000141310593, award355759, N000141410610, award355761, N000141512689)
- China Scholarship Council (award355765, 201506340048)
- Army Research Office (award355760, W911NF1210238)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Keywords
- DNA origami, RNA origami, single-stranded DNA, single-stranded RNA, nucleic acid nanostructures, self-assembly, in vitro replication, in vivo replication, bottom-up nanotechnology
- MeSH terms
- DNA Replication, DNA, Single-Stranded, Escherichia coli, Nucleotides, RNA, Nanotechnology, Nanostructures, RNA Folding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
