The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An evolutionarily conserved gene family encodes proton-selective ion channels
Open accessAbstract
The proton channel behind sour taste: Although many proteins that form ion channels in cell membranes have been described, none that selectively conduct protons into eukaryotic cells have been identified. Tu et al. used a genetic screen to pinpoint candidate genes that might encode such a protein from mouse taste receptor cells (see the Perspective by Montell). They identified the known protein otopetrin and showed that it conferred proton conductance when expressed in cultured human cells. Their results indicate that otopetrin may function in sensory recognition of sour (acidic) taste in humans and other organisms. Science , this issue p. 1047 ; see also p. 991
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137
Cited by
Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
Hu, M., Li, P., Wang, C., Feng, X., Geng, Q., Chen, W., Marthi, M., Zhang, W., Gao, C., Reid, W., et al. (2022) · Cell · doi:10.1016/j.cell.2022.05.021 · Cited by 254
Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus
Teng, B., Kaplan, J. P., Liang, Z., Chyung, K. S., Goldschen-Ohm, M. P., & Liman, E. R. (2023) · eLife · doi:10.7554/elife.85317 · Cited by 16
Self-citation
Metadata
- Authors
- Tu, Y.-H., Cooper, A. J., Teng, B., Chang, R. B., Artiga, D. J., Turner, H. N., Mulhall, E. M., Ye, W., Smith, A. D., & Liman, E. R.
- Venue
- Science
- Published
- 2018-03-02
- Volume
- 359
- Issue
- 6379
- Pages
- 1047-1050
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2784791680
- Cited by
- 313
- References
- 1
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An evolutionarily conserved gene family encodes proton-selective ion channels. https://app.cochat.ai/papers/10.1126/science.aao3264
- The paper
- Tu, Y.-H., Cooper, A. J., Teng, B., Chang, R. B., Artiga, D. J., Turner, H. N., Mulhall, E. M., Ye, W., Smith, A. D., & Liman, E. R. (2018). An evolutionarily conserved gene family encodes proton-selective ion channels. Science. https://doi.org/10.1126/science.aao3264
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
