The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
Open accessAbstract
Lighting the way to drug labeling: It is important during drug development to study how candidate compounds get absorbed and broken down biologically. One common technique for tracking a drug's fate is to label its molecular framework with heavier isotopes of hydrogen (either deuterium or tritium). Loh et al. developed a light-promoted protocol to install these labels on alkyl carbons adjacent to nitrogen. The technique relies on incorporation of the heavy isotope into a thiol from a convenient heavy water source through acid-base chemistry. Next, a photoredox catalyst strips a hydrogen atom equivalent from the carbon, and the thiol engages in radical chemistry to transfer the deuterium or tritium in its place. Science , this issue p. 1182
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Cites
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Cited by
Applications of Deuterium in Medicinal Chemistry
Pirali, T., Serafini, M., Cargnin, S., & Genazzani, A. A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01808 · Cited by 855
Late-stage C–H functionalization offers new opportunities in drug discovery
Guillemard, L., Kaplaneris, N., Ackermann, L., & Johansson, M. J. (2021) · Nature Reviews Chemistry · doi:10.1038/s41570-021-00300-6 · Cited by 837
Metadata
- Authors
- Loh, Y. Y., Nagao, K., Hoover, A. J., Hesk, D., Rivera, N. R., Colletti, S. L., Davies, I. W., & MacMillan, D. W. C.
- Venue
- Science
- Published
- 2017-12
- Volume
- 358
- Issue
- 6367
- Pages
- 1182-1187
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2767689204
- Cited by
- 574
- References
- 25
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Loh, Y. Y., Nagao, K., Hoover, A. J., Hesk, D., Rivera, N. R., Colletti, S. L., Davies, I. W., & MacMillan, D. W. C. (2017). Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds. Science. https://doi.org/10.1126/science.aap9674
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
