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Sphingosine 1-phosphate: Lipid signaling in pathology and therapy
Open accessAbstract
Mediating systemic health: Sphingosine 1-phosphate (S1P) is an important circulating lipid mediator that is derived from the metabolism of cell membranes. Its diverse homeostatic roles, particularly in immunology and vascular biology, can go awry in numerous diseases, including multiple sclerosis, cardiovascular diseases, and fibrosis. The centrality of S1P signaling has led to the development of several drugs, including two approved for treatment of multiple sclerosis. In a Review, Cartier and Hla discuss the current understanding of how one mediator can carry out so many signaling roles in different tissues, how these become dysregulated in disease, and efforts in drug development to target S1P signaling. Science , this issue p. eaar5551
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Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189
Liang, J., Nagahashi, M., Kim, E. Y., Harikumar, K. B., Yamada, A., Huang, W.-C., Hait, N. C., Allegood, J. C., Price, M. M., Avni, D., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.013 · Cited by 563
Vascular and immunobiology of the circulatory sphingosine 1-phosphate gradient
Yanagida, K., & Hla, T. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071635 · Cited by 109
Self-citationDusaban, S. S., Chun, J., Rosen, H., Purcell, N. H., & Brown, J. H. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0882-x · Cited by 106
Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels
Kharel, Y., Morris, E. A., Congdon, M. D., Thorpe, S. B., Tomsig, J. L., Santos, W. L., & Lynch, K. R. (2015) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.225862 · Cited by 67
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Targeting sphingosine-1-phosphate signaling in immune-mediated diseases: beyond multiple sclerosis
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Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160
Autotaxin facilitates selective LPA receptor signaling
Salgado-Polo, F., Borza, R., Matsoukas, M.-T., Marsais, F., Jagerschmidt, C., Waeckel, L., Moolenaar, W. H., Ford, P., Heckmann, B., & Perrakis, A. (2023) · Cell Chemical Biology · doi:10.1016/j.chembiol.2022.12.006 · Cited by 45
Liu, H., Yin, G., Kohlhepp, M. S., Schumacher, F., Hundertmark, J., Hassan, M. I. A., Heymann, F., Puengel, T., Kleuser, B., Mosig, A. S., et al. (2024) · Advanced Science · doi:10.1002/advs.202403516 · Cited by 30
Metadata
- Authors
- Cartier, A., & Hla, T.
- Venue
- Science
- Published
- 2019-10-18
- Volume
- 366
- Issue
- 6463
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2981063663
- Cited by
- 613
- References
- 7
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- green
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