Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
Open accessAbstract
Inflammatory bowel disease is an important risk factor for colorectal cancer. We show that sphingosine-1-phosphate (S1P) produced by upregulation of sphingosine kinase 1 (SphK1) links chronic intestinal inflammation to colitis-associated cancer (CAC) and both are exacerbated by deletion of Sphk2. S1P is essential for production of the multifunctional NF-κB-regulated cytokine IL-6, persistent activation of the transcription factor STAT3, and consequent upregulation of the S1P receptor, S1PR1. The prodrug FTY720 decreased SphK1 and S1PR1 expression and eliminated the NF-κB/IL-6/STAT3 amplification cascade and development of CAC, even in Sphk2(-/-) mice, and may be useful in treating colon cancer in individuals with ulcerative colitis. Thus, the SphK1/S1P/S1PR1 axis is at the nexus between NF-κB and STAT3 and connects chronic inflammation and CAC.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
STAT3 is involved in inflammation-associated carcinogenesis, suppression of the antitumor immune response, and maintenance of cancer stem cells.
“STAT3 is also involved in inflammation-associated carcinogenesis, suppression of the antitumor immune response, and maintenance of cancer stem cells.”
From Critical analysis of the potential for targeting STAT3 in human malignancy (2013) · cites this paper as [95]
The Introduction (page unavailable) links STAT3 activation to the development of colitis-associated cancer. The Discussion (page unavailable) reports that inhibiting STAT3 signaling elicits antitumor immunity, supporting a role in suppressing that response. The passages do not address maintenance of cancer stem cells. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThis process is critically involved in colitis-associated cancer.
“This process is critically involved in colitis-associated cancer (310).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [310]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Histone Deacetylase Inhibitors Suppress the Induction of c-Jun and Its Target Genes Including COX-2
Yamaguchi, K., Lantowski, A., Dannenberg, A. J., & Subbaramaiah, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503201200 · Cited by 80 · see citing works
RetractedImmunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433 · see citing works
Oshima, M., Dinchuk, J. E., Kargman, S., Oshima, H., Hancock, B. C., Kwong, E. C., Trzăskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,363 · see citing works
Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155 · see citing works
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works
Inflammation meets cancer, with NF-κB as the matchmaker
Ben‐Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,378 · see citing works
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Brinkmann, V., Billich, A., Baumruker, T., Heining, P., Schmouder, R., Francis, G., Aradhye, S., & Burtin, P. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3248 · Cited by 1,273 · see citing works
Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220 · see citing works
Intestinal Inflammation and Cancer
Ullman, T. A., & Itzkowitz, S. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.057 · Cited by 1,127 · see citing works
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
Kortylewski, M., Kujawski, M., Wang, T., Sheng, W., Zhang, S., Pilon‐Thomas, S., Niu, G., Kay, H. D., Mulé, J. J., Kerr, W. G., et al. (2005) · Nature Medicine · doi:10.1038/nm1325 · Cited by 1,026 · see citing works
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
Hait, N. C., Allegood, J., Maceyka, M., Strub, G. M., Harikumar, K. B., Singh, S. K., Luo, C., Marmorstein, R., Kordula, T., Milstien, S., et al. (2009) · Science · doi:10.1126/science.1176709 · Cited by 997 · see citing works
Self-citationCold Spring Harbor Perspectives in BiologyPreprint
(2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect_biol/ · Cited by 949 · see citing works
Bollrath, J., Phesse, T. J., von Burstin, V. A., Putoczki, T., Bennecke, M., Bateman, T., Nebelsiek, T., Lundgren-May, T., Canli, Ö., Schwitalla, S., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.002 · Cited by 946 · see citing works
Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein
Yu, C.-L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., & Jove, R. (1995) · Science · doi:10.1126/science.7541555 · Cited by 931 · see citing works
Sphingosine 1-phosphate and cancer
Pyne, N. J., & Pyne, S. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2875 · Cited by 856 · see citing works
Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis
Popivanova, B. K., Kitamura, K., Wu, Y., Kondo, T., Kagaya, T., Kaneko, S., Oshima, M., Fujii, C., & Mukaida, N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32453 · Cited by 845 · see citing works
NF- B as a Critical Link Between Inflammation and CancerPreprint
Karin, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000141 · Cited by 817 · see citing works
The outs and the ins of sphingosine-1-phosphate in immunity
Spiegel, S., & Milstien, S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2974 · Cited by 810 · see citing works
Self-citationSphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
Alvarez, S. E., Harikumar, K. B., Hait, N. C., Allegood, J. C., Strub, G. M., Kim, E. Y., Maceyka, M. W., Jiang, H., Luo, C., Kordula, T., et al. (2010) · Nature · doi:10.1038/nature09128 · Cited by 754 · see citing works
Self-citationTGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling
Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726 · see citing works
Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation
Pitson, S. M., Moretti, P. A. B., Zebol, J. R., Lynn, H. E., Xia, P., Vadas, M. A., & Wattenberg, B. W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg540 · Cited by 543 · see citing works
Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases
Billich, A., Bornancin, F., Dévay, P., Mechtcheriakova, D., Urtz, N., & Baumruker, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307687200 · Cited by 433 · see citing works
Shaner, R. L., Allegood, J. C., Park, H. J., Wang, E. L., Kelly, S. L., Haynes, C. A., Sullards, M. C., & Merrill, A. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.d800051-jlr200 · Cited by 427 · see citing works
Self-citationIL-1β-converting enzyme (caspase-1) in intestinal inflammation
Siegmund, B., Lehr, H.-A., Fantuzzi, G., & Dinarello, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231473998 · Cited by 421 · see citing works
Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway
Xia, P., Gamble, J. R., Rye, K., Wang, L., Hii, C. S. T., Cockerill, P. N., Khew‐Goodall, Y., Bert, A. G., Barter, P. J., & Vadas, M. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14196 · Cited by 408 · see citing works
Sanna, M. G., Wang, S.-K., Gonzalez-Cabrera, P. J., Don, A., Marsolais, D., Matheu, M. P., Wei, S. H., Parker, I., Jo, E., Cheng, W.-C., et al. (2006) · Nature Chemical Biology · doi:10.1038/nchembio804 · Cited by 406 · see citing works
Innate immune mechanisms of colitis and colitis-associated colorectal cancer
Saleh, M., & Trinchieri, G. (2010) · Nature reviews. Immunology · doi:10.1038/nri2891 · Cited by 402 · see citing works
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
Lee, H., Deng, J., Kujawski, M., Yang, C., Liu, Y., Herrmann, A., Kortylewski, M., Horne, D., Somlo, G., Forman, S., et al. (2010) · Nature Medicine · doi:10.1038/nm.2250 · Cited by 395 · see citing works
Li, Y., de Haar, C., Chen, M., Deuring, J., Gerrits, M. M., Smits, R., Xia, B., Kuipers, E. J., & van der Woude, C. J. (2010) · Gut · doi:10.1136/gut.2009.184176 · Cited by 339 · see citing works
Pettus, B. J., Bielawski, J., Porcelli, A. M., Reames, D. L., Johnson, K. R., Morrow, J. D., Chalfant, C. E., Obeid, L. M., & Hannun, Y. A. (2003) · The FASEB Journal · doi:10.1096/fj.02-1038com · Cited by 321 · see citing works
Nagahashi, M., Ramachandran, S., Kim, E. Y., Allegood, J. C., Rashid, O. M., Yamada, A., Zhao, R., Milstien, S., Zhou, H., Spiegel, S., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2167 · Cited by 315 · see citing works
Self-citationThe immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
Paugh, S. W., Payne, S. G., Barbour, S. E., Milstien, S., & Spiegel, S. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01168-2 · Cited by 304 · see citing works
Self-citationCirculating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas
Kim, S., Keku, T. O., Martin, C., Galanko, J., Woosley, J. T., Schroeder, J. C., Satia, J. A., Halabi, S., & Sandler, R. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2924 · Cited by 298 · see citing works
Role for sphingosine kinase 1 in colon carcinogenesis
Kawamori, T., Kaneshiro, T., Okumura, M., Maalouf, S., Uflacker, A. B., Bielawski, J., Hannun, Y. A., & Obeid, L. M. (2008) · The FASEB Journal · doi:10.1096/fj.08-117572 · Cited by 282 · see citing works
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
Zemann, B., Kinzel, B., Müller, M. M., Reuschel, R., Mechtcheriakova, D., Urtz, N., Bornancin, F., Baumruker, T., & Billich, A. (2005) · Blood · doi:10.1182/blood-2005-07-2628 · Cited by 264 · see citing works
S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites
Deng, J., Liu, Y., Lee, H., Herrmann, A., Zhang, W., Zhang, C., Shen, S., Priceman, S. J., Kujawski, M., Pal, S. K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.039 · Cited by 252 · see citing works
Paugh, S. W., Paugh, B. S., Rahmani, M., Kapitonov, D., Almenara, J. A., Kordula, T., Milstien, S., Adams, J. K., Zipkin, R. E., Grant, S., et al. (2008) · Blood · doi:10.1182/blood-2008-02-138958 · Cited by 244 · see citing works
Self-citationWilliams, K. L., Fuller, C. R., Dieleman, L. A., DaCosta, C. M., Haldeman, K., Sartor, R. B., & Lund, P. K. (2001) · Gastroenterology · doi:10.1053/gast.2001.22470 · Cited by 243 · see citing works
Deng, L., Zhou, J.-F., Sellers, R. S., Li, J.-F., Nguyen, A., Wang, Y., Orlofsky, A., Liu, Q., Hume, D. A., Pollard, J. W., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090622 · Cited by 228 · see citing works
Matsumoto, S., Hara, T., Mitsuyama, K., Yamamoto, M., Tsuruta, O., Sata, M., Scheller, J., Rose‐John, S., Kado, S., & Takada, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801217 · Cited by 211 · see citing works
Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation
Kohno, M., Momoi, M., Oo, M. L., Paik, J., Lee, Y.-M., Venkataraman, K., Ai, Y., Ristimaki, A. P., Fyrst, H., Sano, H., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02341-05 · Cited by 210 · see citing works
Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720
Kharel, Y., Lee, S., Snyder, A. H., Sheasley-O’Neill, S. L., Morris, M. A., Setiady, Y. Y., Zhu, R., Zigler, M. A., Burcin, T. L., Ley, K. F., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506293200 · Cited by 210 · see citing works
Sphingosine Kinase 1 Is Associated with Gastric Cancer Progression and Poor Survival of Patients
Li, W., Yu, C.-P., Xia, J.-T., Zhang, L., Weng, G.-X., Zheng, H.-Q., Kong, Q.-L., Hu, L.-J., Zeng, M., Zeng, Y.-X., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1158 · Cited by 189 · see citing works
A role for sphingosine kinase 1 in dextran sulfate sodium‐induced colitis
Snider, A. J., Kawamori, T., Bradshaw, S. G., Orr, K. A., Gilkeson, G. S., Hannun, Y. A., & Obeid, L. M. (2008) · The FASEB Journal · doi:10.1096/fj.08-118109 · Cited by 187 · see citing works
Tonelli, F., Lim, K. G., Loveridge, C. J., Long, J. S., Pitson, S. M., Tigyi, G., Bittman, R., Pyne, S., & Pyne, N. J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.05.022 · Cited by 181 · see citing works
Palma, C. D., Meacci, E., Perrotta, C., Bruni, P., & Clementi, E. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000194074.59584.42 · Cited by 164 · see citing works
FTY720 Analogues as Sphingosine Kinase 1 Inhibitors
Lim, K. G., Tonelli, F., Li, Z., Lu, X., Bittman, R., Pyne, S., & Pyne, N. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220756 · Cited by 115 · see citing works
Liu, Y., Deng, J., Wang, L., Lee, H., Armstrong, B., Scuto, A., Kowolik, C. M., Weiss, L. M., Forman, S. J., & Yu, H. (2012) · Blood · doi:10.1182/blood-2011-12-399030 · Cited by 101 · see citing works
Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration
Gao, P., & Smith, C. D. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0336 · Cited by 100 · see citing works
The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice
Deguchi, Y., Andoh, A., Yagi, Y., Bamba, S., Inatomi, O., Tsujikawa, T., & Fujiyama, Y. (2006) · Oncology Reports · doi:10.3892/or.16.4.699 · Cited by 91 · see citing works
Interleukin-1 Regulates the Expression of Sphingosine Kinase 1 in Glioblastoma Cells
Paugh, B. S., Bryan, L., Paugh, S. W., Wilczynska, K. M., Álvarez, S. M., Singh, S. K., Kapitonov, D., Rokita, H., Wright, S., Griswold‐Prenner, I., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807170200 · Cited by 90 · see citing works
Self-citationSchiechl, G., Bauer, B., Fuss, I. J., Lang, S. A., Moser, C., Ruemmele, P., Rose‐John, S., Neurath, M. F., Geissler, E. K., Schlitt, H. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42540 · Cited by 87 · see citing works
Scherer, E. Q., Yang, J., Canis, M., Reimann, K., Ivanov, K., Diehl, C., Backx, P. H., Wier, W. G., Strieth, S., Wangemann, P., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.593327 · Cited by 87 · see citing works
Rakhit, S., Conway, A.-M., Tate, R. J., BOWER, T., Pyne, N. J., & Pyne, S. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3380643 · Cited by 86 · see citing works
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions
Daniel, C., Sartory, N. A., Zahn, N., Schmidt, R., Geißlinger, G., Radeke, H. H., & Stein, J. M. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.02.026 · Cited by 58 · see citing works
Accumulation of Fingolimod (FTY720) in Lymphoid Tissues Contributes to Prolonged Efficacy
Sensken, S.-C., Bode, C., & Gräler, M. H. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.148163 · Cited by 50 · see citing works
Samy, E. T., Meyer, C. A., Caplazi, P., Langrish, C. L., Lora, J. M., Bluethmann, H., & Peng, S. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5644 · Cited by 47 · see citing works
Sobue, S., Murakami, M., Banno, Y., Ito, H., Kimura, A., Gao, S., Furuhata, A., Takagi, A., Kojima, T., Suzuki, M., et al. (2008) · Oncogene · doi:10.1038/onc.2008.198 · Cited by 36 · see citing works
Lindström, T. M., Mohan, A. R., Johnson, M. R., & Bennett, P. R. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.042838 · Cited by 27 · see citing works
Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Sphingolipids and their metabolism in physiology and disease
Hannun, Y. A., & Obeid, L. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.107 · Cited by 2,073 · see citing works
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000 · see citing works
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Yu, H., Lee, H., Herrmann, A., Buettner, R., & Jove, R. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3818 · Cited by 2,137 · see citing works
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“This process is critically involved in colitis-associated cancer (310).”
BackgroundLipid metabolic reprogramming in cancer cells
Beloribi‐Djefaflia, S., Vasseur, S., & Guillaumond, F. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.49 · Cited by 1,392 · see citing works
Sphingolipid metabolites in inflammatory disease
Maceyka, M. W., & Spiegel, S. (2014) · Nature · doi:10.1038/nature13475 · Cited by 1,284 · see citing works
Self-citationSphingolipid metabolism in cancer signalling and therapy
Ogretmen, B. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.96 · Cited by 1,207 · see citing works
Zhang, M., Viennois, É., Prasad, M. A., Zhang, Y., Wang, L., Zhang, Z., Han, M. K., Xiao, B., Xu, C., Srinivasan, S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.018 · Cited by 1,037 · see citing works
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
Taniguchi, K., & Karin, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.001 · Cited by 713 · see citing works
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy
Cartier, A., & Hla, T. (2019) · Science · doi:10.1126/science.aar5551 · Cited by 625 · see citing works
Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Butler, L. M., Perone, Y., Dehairs, J., Lupien, L. E., de Laat, V., Talebi, A., Loda, M. F., Kinlaw, W. B., & Swinnen, J. V. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.013 · Cited by 617 · see citing works
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Proia, R. L., & Hla, T. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76369 · Cited by 528 · see citing works
An update on the biology of sphingosine 1-phosphate receptors
Blaho, V. A., & Hla, T. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046300 · Cited by 516 · see citing works
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
Kunkel, G. T., Maceyka, M. W., Milstien, S., & Spiegel, S. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4099 · Cited by 437 · see citing works
Self-citationmTORC2 Promotes Tumorigenesis via Lipid Synthesis
Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.011 · Cited by 410 · see citing works
Emerging cytokine networks in colorectal cancer
West, N. R., McCuaig, S., Franchini, F., & Powrie, F. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3896 · Cited by 400 · see citing works
Lipid metabolism in cancer progression and therapeutic strategies
Fu, Y., Zou, T., Shen, X., Nelson, P. J., Li, J., Wu, C., Yang, J., Zheng, Y., Bruns, C. J., Zhao, Y., et al. (2020) · MedComm · doi:10.1002/mco2.27 · Cited by 406 · see citing works
Bioactive lipids, inflammation and chronic diseases
Leuti, A., Fazio, D., Fava, M., Piccoli, A., Oddi, S., & Maccarrone, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.028 · Cited by 368 · see citing works
STAT proteins in cancer: orchestration of metabolism
Li, Y., Zhang, C., Martincuks, A., Herrmann, A., & Yu, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00537-3 · Cited by 287 · see citing works
Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy
Newton, J. C., Lima, S., Maceyka, M. W., & Spiegel, S. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.025 · Cited by 284 · see citing works
Self-citationThe role of diet in the aetiopathogenesis of inflammatory bowel disease
Khalili, H., Chan, S. S. M., Lochhead, P. J., Ananthakrishnan, A. N., Hart, A. R., & Chan, A. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0022-9 · Cited by 284 · see citing works
Cancer Inflammation and CytokinesPreprint
Galdiero, M. R., Marone, G., & Mantovani, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028662 · Cited by 267 · see citing works
Munn, L. L. (2016) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1370 · Cited by 264 · see citing works
Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats
Zhu, L., Gu, P., & Shen, H. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.036 · Cited by 253 · see citing works
Nagahashi, M., Yamada, A., Katsuta, E., Aoyagi, T., Huang, W., Terracina, K. P., Hait, N. C., Allegood, J. C., Tsuchida, J., Yuza, K., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1423 · Cited by 223 · see citing works
Self-citationTsai, H., & Han, M. H. (2016) · Drugs · doi:10.1007/s40265-016-0603-2 · Cited by 212 · see citing works
Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate
Gómez‐Muñoz, A., Presa, N., Gómez-Larrauri, A., Rivera, I.-G., Trueba, M., & Ordoñez, M. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.09.002 · Cited by 211 · see citing works
Hait, N. C., Wise, L. E., Allegood, J. C., O'Brien, M., Avni, D., Reeves, T. M., Knapp, P. E., Lu, J., Luo, C., Miles, M. F., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3728 · Cited by 209 · see citing works
Self-citationSTAT3 and epithelial–mesenchymal transitions in carcinomas
Wendt, M. K., Balanis, N. G., Carlin, C. R., & Schiemann, W. P. (2014) · JAK-STAT · doi:10.4161/jkst.28975 · Cited by 201 · see citing works
Kasembeli, M. M., Bharadwaj, U., Robinson, P., & Tweardy, D. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082299 · Cited by 199 · see citing works
Medina, C. B., & Ravichandran, K. S. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.13 · Cited by 196 · see citing works
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances
Pyne, S., Adams, D. R., & Pyne, N. J. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.03.001 · Cited by 190 · see citing works
O’Connor, C. M., Perl, A. L., Léonard, D., Sangodkar, J., & Narla, G. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.10.008 · Cited by 181 · see citing works
The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
Hait, N. C., & Maiti, A. (2017) · Mediators of Inflammation · doi:10.1155/2017/4806541 · Cited by 189 · see citing works
Self-citationA basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness
Kim, T., Yang, S.-J., Hwang, D., Song, J., Kim, M., Kim, S. K., Kang, K., Ahn, J., Lee, D., Kim, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms10186 · Cited by 181 · see citing works
STAT3: a multifaceted oncoprotein
Guanizo, A. C., Fernando, C. D., Garama, D. J., & Gough, D. J. (2018) · Growth Factors · doi:10.1080/08977194.2018.1473393 · Cited by 176 · see citing works
The emerging role of FTY720 (Fingolimod) in cancer treatment
White, C., Alshaker, H. A., Cooper, C., Winkler, M. H., & Pchejetski, D. (2016) · Oncotarget · doi:10.18632/oncotarget.7145 · Cited by 168 · see citing works
Roles, regulation and inhibitors of sphingosine kinase 2
Neubauer, H. A., & Pitson, S. M. (2013) · FEBS Journal · doi:10.1111/febs.12314 · Cited by 168 · see citing works
González, N., Prieto, I., del Puerto‐Nevado, L., Portal‐Núñez, S., Ardura, J. A., Cortón, M., Fernández‐Fernández, B., Aguilera, Ó., Gómez‐Guerrero, C., Mas, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14472 · Cited by 169 · see citing works
Xiang, M. H., Birkbak, N. J., Vafaizadeh, V., Walker, S. R., Yeh, J., Liu, S., Kroll, Y., Boldin, M., Taganov, K. D., Groner, B., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004497 · Cited by 166 · see citing works
Export of sphingosine-1-phosphate and cancer progression
Takabe, K., & Spiegel, S. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046656 · Cited by 165 · see citing works
Self-citationRoles of sphingosine-1-phosphate signaling in cancer
Wang, P., Yuan, Y., Lin, W., Zhong, H., Xu, K., & Qi, X. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1014-8 · Cited by 156 · see citing works
Degagné, É., Pandurangan, A. K., Bandhuvula, P., Kumar, A., Eltanawy, A., Zhang, M., Yoshinaga, Y., Nefedov, M. D., de Jong, P. J., Fong, L. G., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74188 · Cited by 155 · see citing works
Selvam, S. P., Palma, R. M. D., Oaks, J. J., Oleinik, N. V., Peterson, Y. K., Stahelin, R. V., Skordalakes, E., Ponnusamy, S., Garrett-Mayer, E. S., Smith, C. D., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aaa4998 · Cited by 150 · see citing works
Sukocheva, O. A., Furuya, H., Ng, M. L., Friedemann, M., Menschikowski, M., Tarasov, V. V., Chubarev, V. N., Klochkov, S. G., Евгеньевна, Н. М., Mangoni, A. A., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107464 · Cited by 147 · see citing works
Immunological Mechanisms in Inflammation-Associated Colon Carcinogenesis
Hirano, T., Hirayama, D., Wagatsuma, K., Yamakawa, T., Yokoyama, Y., & Nakase, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093062 · Cited by 145 · see citing works
Lipidomics in translational research and the clinical significance of lipid-based biomarkers
Stephenson, D., Hoeferlin, L. A., & Chalfant, C. E. (2017) · Translational research · doi:10.1016/j.trsl.2017.06.006 · Cited by 136 · see citing works
Pyne, N. J., McNaughton, M., Boomkamp, S. D., MacRitchie, N. A., Evangelisti, C., Martelli, A. M., Jiang, H., Ubhi, S., & Pyne, S. (2015) · Advances in Biological Regulation · doi:10.1016/j.jbior.2015.09.001 · Cited by 131 · see citing works
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease
Verstockt, B., Vetrano, S., Salas, A., Nayeri, S., Duijvestein, M., Casteele, N. V., Danese, S., D’Haens, G., Eckmann, L., Faubion, W. A., et al. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00574-7 · Cited by 133 · see citing works
Wang, M., Liang, C., Hu, H., Zhou, L., Xu, B., Wang, X., Han, Y., Nie, Y., Jia, S., Liang, J., et al. (2016) · Scientific Reports · doi:10.1038/srep30696 · Cited by 130 · see citing works
Self-citationSphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater
Weigert, A., Olesch, C., & Brüne, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01706 · Cited by 127 · see citing works
G protein-coupled receptors as promising cancer targets
Liu, Y., An, S., Ward, R. J., Yang, Y., Guo, X., Li, W., & Xu, T. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.031 · Cited by 128 · see citing works
Lucafò, M., Curci, D., Franzin, M., Decorti, G., & Stocco, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.772101 · Cited by 130 · see citing works
The role of sphingosine‐1‐phosphate in inflammation and cancer progression
Nagahashi, M., Abe, M., Sakimura, K., Takabe, K., & Wakai, T. (2018) · Cancer Science · doi:10.1111/cas.13802 · Cited by 125 · see citing works
Self-citationEvolving concepts in cancer therapy through targeting sphingolipid metabolism
Truman, J., Garcı́a-Barros, M., Obeid, L. M., & Hannun, Y. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.12.013 · Cited by 124 · see citing works
Yao, C., Su, L., Shan, J., Zhu, C., Liu, L., Liu, C., Xu, Y., Yang, Z., Bian, X., Shao, J., et al. (2016) · Stem Cells · doi:10.1002/stem.2320 · Cited by 123 · see citing works
The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases
Nagahashi, M., Yuza, K., Hirose, Y., Nakajima, M., Ramanathan, R., Hait, N. C., Hylemon, P. B., Zhou, H., Takabe, K., & Wakai, T. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r069286 · Cited by 118 · see citing works
Self-citationApigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
Ai, X., Qin, Y., Liu, H.-J., Cui, Z.-H., Li, M., Yang, J., Zhong, W., Liu, Y., Chen, S., Sun, T., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22145 · Cited by 116 · see citing works
Targeting transcription factors
Yeh, J., Toniolo, P. A., & Frank, D. A. (2013) · Current Opinion in Oncology · doi:10.1097/01.cco.0000432528.88101.1a · Cited by 109 · see citing works
Vascular and immunobiology of the circulatory sphingosine 1-phosphate gradient
Yanagida, K., & Hla, T. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071635 · Cited by 109 · see citing works
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Valdés-Rives, S. A., & González‐Arenas, A. (2017) · Mediators of Inflammation · doi:10.1155/2017/9173090 · Cited by 106 · see citing works
Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration
Clark, A. R., & Ohlmeyer, M. H. J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.016 · Cited by 106 · see citing works
Hait, N. C., Avni, D., Yamada, A., Nagahashi, M., Aoyagi, T., Aoki, H., Dumur, C. I., Zelenko, Z., Gallagher, E. J., LeRoith, D., et al. (2015) · Oncogenesis · doi:10.1038/oncsis.2015.16 · Cited by 104 · see citing works
Self-citationCrystal Structure of Sphingosine Kinase 1 with PF-543
Wang, J., Knapp, S., Pyne, N. J., Pyne, S., & Elkins, J. M. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml5004074 · Cited by 104 · see citing works
S1P signaling: new therapies and opportunities
Gonzalez‐Cabrera, P. J., Brown, S. D. M., Studer, S. M., & Rosen, H. (2014) · F1000Prime Reports · doi:10.12703/p6-109 · Cited by 104 · see citing works
Bao, Y., Chen, Z., Guo, Y., Feng, Y., Li, Z., Han, W., Wang, J., Zhao, W., Jiao, Y., Li, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105991 · Cited by 102 · see citing works
Okano, M., Oshi, M., Butash, A. L., Katsuta, E., Tachibana, K., Saito, K., Okayama, H., Peng, X., Yan, L., Kono, K., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174197 · Cited by 101 · see citing works
Self-citationVenkata, J. K., An, N., Stuart, R. K., Costa, L. J., Cai, H., Coker, W. J., Song, J. H., Gibbs, K., Matson, T., Garrett-Mayer, E. S., et al. (2014) · Blood · doi:10.1182/blood-2014-03-559385 · Cited by 101 · see citing works
High levels of sphingolipids in human breast cancer
Nagahashi, M., Tsuchida, J., Moro, K., Hasegawa, M. L., Tatsuda, K., Woelfel, I. A., Takabe, K., & Wakai, T. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.05.022 · Cited by 101 · see citing works
Self-citationRutherford, C., Childs, S., Ohotski, J., McGlynn, L. M., Riddick, M., Macfarlane, S. R., Tasker, D., Pyne, S., Pyne, N. J., Edwards, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.455 · Cited by 100 · see citing works
S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3
Priceman, S. J., Shen, S., Wang, L., Deng, J., Yue, C., Kujawski, M., & Yu, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.016 · Cited by 99 · see citing works
Garcı́a-Barros, M., Coant, N., Truman, J., Snider, A. J., & Hannun, Y. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.09.007 · Cited by 98 · see citing works
Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
Nagahashi, M., Takabe, K., Terracina, K. P., Soma, D., Hirose, Y., Kobayashi, T., Matsuda, Y., & Wakai, T. (2014) · BioMed Research International · doi:10.1155/2014/651727 · Cited by 97 · see citing works
Self-citationAcid ceramidase is upregulated in AML and represents a novel therapeutic target
Tan, S., Liu, X., Fox, T. E., Barth, B. M., Sharma, A. K., Turner, S., Awwad, A., Dewey, A., Doi, K., Spitzer, B. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13079 · Cited by 97 · see citing works
Morris, G., Bortolasci, C. C., Puri, B. K., Marx, W., O'Neil, A. E., Athan, E., Walder, K. R., Berk, M., OLIVE, L. S., Carvalho, A. F., et al. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155593 · Cited by 97 · see citing works
Ala, M., & Ala, M. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00167 · Cited by 96 · see citing works
Danese, S., Furfaro, F., & Vetrano, S. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx107 · Cited by 94 · see citing works
Recent advances in the development of sphingosine kinase inhibitors
Pitman, M. R., Costabile, M., & Pitson, S. M. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.06.007 · Cited by 93 · see citing works
Zhang, H., Xu, Z.-S., Lin, H. I., Li, M., Xia, T., Cui, K., Wang, S., Li, Y., Shu, H., & Wang, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-05796-z · Cited by 91 · see citing works
Zhang, F., Xia, Y., Yan, W., Zhang, H., Zhou, F., Zhao, S., Wang, W., Zhu, D., Xin, C., Lee, Y., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00372.2015 · Cited by 91 · see citing works
Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity
Ansari, S., Gantuya, B., Tuan, V. P., & Yamaoka, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082424 · Cited by 90 · see citing works
Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
Boldyreva, L. V., Morozova, M. V., Medvedeva, S. S., & Kozhevnikova, E. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111682 · Cited by 90 · see citing works
Deng, Z., Mu, J., Tseng, M. T., Wattenberg, B. W., Zhuang, X., Egilmez, N. K., Wang, Q., Zhang, L., Norris, J. S., Guo, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms7956 · Cited by 91 · see citing works
Colorectal Cancer in Ulcerative Colitis: Mechanisms, Surveillance and Chemoprevention
Li, W., Zhao, T., Wu, D., Li, J., Wang, M., Sun, Y., & Hou, S. (2022) · Current Oncology · doi:10.3390/curroncol29090479 · Cited by 91 · see citing works
Ceramide species are elevated in human breast cancer and are associated with less aggressiveness
Moro, K., Kawaguchi, T., Tsuchida, J., Gabriel, E. M., Qi, Q., Yan, L., Wakai, T., Takabe, K., & Nagahashi, M. (2018) · Oncotarget · doi:10.18632/oncotarget.24903 · Cited by 88 · see citing works
Self-citationOshi, M., Newman, S., Tokumaru, Y., Yan, L., Matsuyama, R., Endo, I., Nagahashi, M., & Takabe, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186708 · Cited by 89 · see citing works
Self-citationvon Manstein, V., Yang, C., Richter, D. E., Delis, N., Vafaizadeh, V., & Groner, B. (2014) · Current Signal Transduction Therapy · doi:10.2174/1574362409666140206221931 · Cited by 87 · see citing works
Mechanisms of sphingosine 1-phosphate receptor signalling in cancer
Patmanathan, S. N., Wang, W., Yap, L. F., Herr, D. R., & Paterson, I. C. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.03.002 · Cited by 87 · see citing works
Lankadasari, M. B., Aparna, J. S., Mohammed, S., James, S., Aoki, K., Binu, V. S. N., Nair, S., & Harikumar, K. B. (2018) · Theranostics · doi:10.7150/thno.25308 · Cited by 87 · see citing works
Self-citationMechanisms of Ceramide-Dependent Cancer Cell Death
Nganga, R., Oleinik, N. V., & Öğretmen, B. (2018) · Advances in cancer research · doi:10.1016/bs.acr.2018.04.007 · Cited by 87 · see citing works
Wang, X., Zhang, D., Gu, T., Ding, X., Fan, C., Zhu, Q., Shi, Y., Hong, Y., & Kong, L. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.10.005 · Cited by 86 · see citing works
Moro, K., Nagahashi, M., Ramanathan, R., Takabe, K., & Wakai, T. (2016) · World Journal of Clinical Cases · doi:10.12998/wjcc.v4.i7.155 · Cited by 86 · see citing works
Self-citationSphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells
Pyne, N. J., & Pyne, S. (2017) · Molecules · doi:10.3390/molecules22030344 · Cited by 86 · see citing works
Donoviel, M. S., Hait, N. C., Ramachandran, S., Maceyka, M. W., Takabe, K., Milstien, S., Oravecz, T., & Spiegel, S. (2015) · The FASEB Journal · doi:10.1096/fj.15-274936 · Cited by 84 · see citing works
Self-citationSphingosine-1-phosphate in chronic intestinal inflammation and cancer
Nagahashi, M., Hait, N. C., Maceyka, M. W., Avni, D., Takabe, K., Milstien, S., & Spiegel, S. (2013) · Advances in Biological Regulation · doi:10.1016/j.jbior.2013.10.001 · Cited by 83 · see citing works
Self-citationBohonowych, J. E. S., Hance, M. W., Nolan, K., DeFee, M. R., Parsons, C., & Isaacs, J. (2013) · The Prostate · doi:10.1002/pros.22761 · Cited by 82 · see citing works
Olesch, C., Ringel, C., Brüne, B., & Weigert, A. (2017) · Mediators of Inflammation · doi:10.1155/2017/6059203 · Cited by 82 · see citing works
Regulation of PP2A by Sphingolipid Metabolism and Signaling
Oaks, J. J., & Öğretmen, B. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2014.00388 · Cited by 82 · see citing works
Shao, Y., Nanayakkara, G., Cheng, J., Cueto, R., Yang, W. Y., Park, J., Wang, H., & Yang, X. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7069 · Cited by 81 · see citing works
The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy
Sheridan, M., & Öğretmen, B. (2021) · Cancers · doi:10.3390/cancers13102475 · Cited by 79 · see citing works
- Authors
- Liang, J., Nagahashi, M., Kim, E. Y., Harikumar, K. B., Yamada, A., Huang, W.-C., Hait, N. C., Allegood, J. C., Price, M. M., Avni, D., Takabe, K., Kordula, T., Milstien, S., & Spiegel, S.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Spiegel, Sarah
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 23
- Issue
- 1
- Pages
- 107-120
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3578577
- OpenAlex
- W2145876349
- Cited by
- 563
- References
- 62
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 35 · 2023: 20 · 2022: 37 · 2021: 45 · 2020: 51 · 2019: 42 · 2018: 44 · 2017: 57 · 2016: 59 · 2015: 48 · 2014: 48 · 2013: 25 · 2012: 1
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Susan G. Komen
- National Institutes of Health (5k12hd055881-05)
- Japan Society for the Promotion of Science
- National Heart, Lung, and Blood Institute (T32HL094290)
- National Cancer Institute (P30CA16059, R01CA160688, R01CA-61774, R01CA061774, P30CA016059)
- National Institute of General Medical Sciences (R37GM043880)
- National Institute of Allergy and Infectious Diseases (U19AI077435)
- National Institute of Neurological Disorders and Stroke (P30NS047463)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD055881)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- sphingosine-1-phosphate, sphingosine kinase 1, sphingosine kinase 2, S1PR1, STAT3 activation, NF-κB, interleukin-6, colitis-associated colorectal cancer, inflammatory bowel disease, ulcerative colitis, fingolimod, chronic intestinal inflammation, colorectal cancer
- MeSH terms
- Fingolimod Hydrochloride, Sphingosine Kinase, Animals, Cell Transformation, Neoplastic, Colitis, Colon, Lysophospholipids, Propylene Glycols, Sphingosine, Interleukin-6, Gene Expression Regulation, Neoplastic, NF-kappa B, Gene Deletion, Phosphotransferases (Alcohol Group Acceptor), STAT3 Transcription Factor, Mice, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
