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Quantitative mass imaging of single biological macromolecules
Open accessAbstract
Watching proteins' weight: Careful measurements of light scattering can provide information on individual macromolecules and complexes. Young et al. used a light-scattering approach for accurate mass determination of proteins as small as 20 kDa (see the Perspective by Lee and Klenerman). Movies of protein complex association and dissociation were analyzed to extract biophysical parameters from single molecules and assemblies without labeling. Using this approach, the authors determined in vitro kinetics of fibril and aggregate growth and association constants for a complex protein-glycoprotein assembly. Science , this issue p. 423 ; see also p. 378
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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Galvagnion, C., Buell, A. K., Meisl, G., Michaels, T. C. T., Vendruscolo, M., Knowles, T. P. J., & Dobson, C. M. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1750 · Cited by 661
Cited by
Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663
Regulation of microtubule dynamics, mechanics and function through the growing tip
Gudimchuk, N. B., & McIntosh, J. R. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00399-x · Cited by 369
Identification and Quantification of Proteoforms by Mass Spectrometry
Schaffer, L. V., Millikin, R. J., Miller, R. M., Anderson, L. C., Fellers, R. T., Ge, Y., Kelleher, N. L., LeDuc, R. D., Liu, X., Payne, S. H., et al. (2019) · PROTEOMICS · doi:10.1002/pmic.201800361 · Cited by 209
Gimpel, A. L., Katsikis, G., Sha, S., Maloney, A. J., Hong, M. S., Nguyen, T. N. T., Wolfrum, J., Springs, S. L., Sinskey, A. J., Manalis, S. R., et al. (2021) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2021.02.010 · Cited by 185
Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
(2023) · doi:10.1016/j.molcel.2023.04.026 · Cited by 47
Metadata
- Authors
- Young, G., Hundt, N., Cole, D., Fineberg, A., Andrecka, J., Tyler, A., Olerinyova, A., Ansari, A., Marklund, E. G., Collier, M. P., Chandler, S. A., Tkachenko, O., Allen, J., Crispin, M., Billington, N., Takagi, Y., Sellers, J. R., Eichmann, C., Selenko, P., Frey, L., Riek, R., Galpin, M. R., Struwe, W. B., Benesch, J. L. P., & Kukura, P.
- Venue
- Science
- Published
- 2018-04-27
- Volume
- 360
- Issue
- 6387
- Pages
- 423-427
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2801919855
- Cited by
- 753
- References
- 1
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Young, G., Hundt, N., Cole, D., Fineberg, A., Andrecka, J., Tyler, A., Olerinyova, A., Ansari, A., Marklund, E. G., Collier, M. P., Chandler, S. A., Tkachenko, O., Allen, J., Crispin, M., Billington, N., Takagi, Y., Sellers, J. R., Eichmann, C., Selenko, P., . . . Kukura, P. (2018). Quantitative mass imaging of single biological macromolecules. Science. https://doi.org/10.1126/science.aar5839
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