The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Holth, Jerrah K., Fritschi, Sarah K., Wang, Chanung, Pedersen, Nigel P., Cirrito, John R., Mahan, Thomas E., Finn, Mary Beth, Manis, Melissa, Geerling, Joel C., Fuller, Patrick M., Lucey, Brendan P., Holtzman, David M.·2019·Science
Cited by (817)
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- Slow Wave Sleep Reduces CSF Concentrations of Beta-amyloid and Tau: A Randomized Crossover Study in Healthy AdultsTim Lyckenvik, Martin Olsson, My Forsberg, Pontus Wasling, Henrik Zetterberg, Jan Anders Hedner, Eric Hanse · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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- Ps19 Mouse Tauopathy Causes Sex-Dependent Sleep Loss and Hyperarousal, and Predicts Cognitive PerformanceJarrah Oran-Zoreia Juvris Kron, Heather J. Daykin, Jeremy A. Metha, Yasmin Potts, Leigh C. Walker, Giancarlo Allocca, Ryan J. Keenan, Daniël Hoyer, Laura H. Jacobson · 2025 · SSRN Electronic Journal
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- Drosophila pyruvate kinase links metabolic state with circadian output via TARANIS and PDFSang‐Hyuk Lee, Oghenerukevwe Akpoghiran, So Who Kang, Eunjoo Cho, Ji Min Ahn, Min‐Ji Kang, Kyunghee Koh, Eun Young Kim · 2026 · Communications Biology
- Closed-loop phase-locked auditory stimulation system at home enhance slow wave sleep for patients with chronic insomnia: A randomized, placebo-controlled trialQianqian Zhang, Mingsu Liu, Guannan Xi, Xin Zheng, Anchen Gao, Siyang Huang, Jian Ping Jiang, Jing Ding, Xin Wang · 2025 · Research Square
- Effects of Improved Sleep and Gastric Vagotomy on Serum Inflammatory Mediators in Peptic Ulcer RatsHuang Du, Lianxiang Peng, Guohua Gong, Shuping Xiao, Rongpan Lin, Kangming Huang, Mingxia Wu, Nating Wei, Wangfeng Cai, Hongbin Chen · 2025 · Neurogastroenterology & Motility
- Impact of Mild Traumatic Brain Injury on Sleep Patterns in Younger Individuals: A Systematic ReviewSid Subramanian, Caitlin M. Carroll · 2025 · Neurotrauma Reports
- Sleep deprivation exhibits age-dependent effect on infra-slow global brain activityYibing Yang, Weiwei Zhao, Yutong Mao, Tianxin Mao, Yao Deng, Yifan Yang, Hengyi Rao, Xiao Liu · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Papaverine enhances autophagy, synaptic function, and memory in a mouse model of chronic REM sleep deprivationAbid Bhat, Muhammed Bishir, Manjunath Kalyan, Pablo Torterolo, Sulie L. Chang, Seithikurippu Ratnas Pandi-Perumal, Saravana Babu Chidambaram · 2025 · NeuroImmune Pharmacology and Therapeutics
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- Treatment of Alzheimer’s DiseaseJeffrey L. Cummings · 2025 · Cambridge University Press eBooks
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- Additional file 2 of Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafishJ.‐M. Park, Kim, Dong Yeol, Geum Sook Hwang, Han, Inn-Oc · 2024 · Figshare
- Additional file 1 of Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementiaSun, Lin, Zhang, Jie, Li, Wei, 盛建华, Shifu Xiao · 2024 · Figshare
- Additional file 1 of Self-reported sleep characteristics associated with dementia among rural-dwelling Chinese older adults: a population-based studyLiu, Rui, Tang, Shi, Wang, Yongxiang, Yi Dong, Hou, Tingting, Yifei Ren, Cong, Lin, Liu, Keke, Qin, Yu, Shireen Sindi et al. · 2022 · Figshare
- Additional file 3 of Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafishJ.‐M. Park, Kim, Dong Yeol, Geum Sook Hwang, Han, Inn-Oc · 2024 · Figshare
- Additional file 4 of Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafishJ.‐M. Park, Kim, Dong Yeol, Geum Sook Hwang, Han, Inn-Oc · 2024 · Figshare
- Additional file 2 of Microglial exosomes alleviate intermittent hypoxia-induced cognitive deficits by suppressing NLRP3 inflammasomeZhang, Yaodan, Yuyang Miao, Xiong, Xiangyang, Jin Tan, Han, Zhaoli, Chen, Fanglian, Lei, Ping, Zhang, Qiang · 2023 · Figshare
- Additional file 5 of Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafishJ.‐M. Park, Kim, Dong Yeol, Geum Sook Hwang, Han, Inn-Oc · 2024 · Figshare
- Additional file 1 of Altered hippocampal transcriptome dynamics following sleep deprivationMarie E. Gaine, Ethan Bahl, Snehajyoti Chatterjee, Michaelson, Jacob J., Ted G. Abel, Lisa C. Lyons · 2021 · Figshare
- Additional file 1 of Microglial exosomes alleviate intermittent hypoxia-induced cognitive deficits by suppressing NLRP3 inflammasomeZhang, Yaodan, Yuyang Miao, Xiong, Xiangyang, Jin Tan, Han, Zhaoli, Chen, Fanglian, Lei, Ping, Zhang, Qiang · 2023 · Figshare
- Additional file 3 of Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementiaSun, Lin, Zhang, Jie, Li, Wei, 盛建华, Shifu Xiao · 2024 · Figshare
- Additional file 2 of Neutrophil activation may trigger tau burden contributing to cognitive progression of chronic sleep disturbance in elderly individuals not living with dementiaSun, Lin, Zhang, Jie, Li, Wei, Sheng, Jianhua, Shifu Xiao · 2024 · Figshare
- Additional file 1 of Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer’s disease neuropathology in adult zebrafishJ.‐M. Park, Kim, Dong Yeol, Geum Sook Hwang, Han, Inn-Oc · 2023 · Figshare
- Additional file 12 of Impact of APOE genotype on prion-type propagation of tauopathyTristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, Xu, Guilian, McFarland, Karen, Benoit I. Giasson, Patrick M. Sullivan, Borchelt, David R. et al. · 2022 · Figshare
- Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humansGeoffrey Canet, Felipe Da Gama Monteiro, Emma Rocaboy, Sofia Diego-Diàz, Boutheyna Khelaifia, Jessica Kim, Daphne I. Valencia, Audrey Yin, Hau‐Tieng Wu, Jordan Howell et al. · 2024 · Research Square
- Additional file 1 of Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burdenEmily W. Paolillo, Rowan Saloner, Anna M. VandeBunte, Lee, Shannon, Bennett, David A., Kaitlin Blackstone Casaletto · 2024 · Figshare
- Additional file 1 of Remote evaluation of sleep to enhance understanding of early dementia due to Alzheimer’s Disease (RESTED-AD): an observational cohort study protocolJonathan Blackman, Hamish Duncan Morrison, Victoria Grace Gabb, Bijetri Biswas, Haoxuan Li, Turner, Nicholas, Amy Jolly, William R. Trender, Adam Hampshire, Alan L. Whone et al. · 2023 · Figshare
- A meningeal circadian clock and brain state co-ordinately enhance macromolecular clearance during wakeTalya Goble, Tanushree Kundu, Léticia S. Meyer, Dimitra Klinaki, Thomas A. Hawkins, Jason Rihel · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body DiseaseJun Ueda, Norihito Uemura, Jiarui Chang, Tetsuya Hirato, Tomoyuki Ishimoto, Miki Oono, Shu‐ichi Matsuzawa, Riki Matsumoto, Hodaka Yamakado, Ryōsuke Takahashi · 2026 · Movement Disorders
- Climate change and dementia: the impacts of social inequalitiesXiaowen Zhou, Ding Ding · 2025 · Current Opinion in Psychiatry
- Diagnostic association of ante-mortem biomarkers with cerebral amyloid angiopathy in a cohort with high Alzheimer's disease comorbidityKemi Hou, Haojun Lu, Rong Zhang, Yadong Wang, Ge Xu, Fengdan Long, Juan Lu, Dong Ming Xing, Lingling Huang, Yaming Sun et al. · 2026 · Journal of Alzheimer s Disease Reports
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