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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
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Abstract
Sleep may protect the brain from AD: Two main proteins accumulate in the brain in Alzheimer's disease (AD), β-amyloid (Aβ) and tau. Aβ appears to instigate AD, but tau appears to drive brain damage and cognitive decline. Sleep deprivation is known to increase Aβ acutely and chronically. Now, Holth et al. show that chronic sleep deprivation strongly increases tau acutely over hours and also drives tau pathology spreading in the brains of mice and humans (see the Perspective by Noble and Spires-Jones). Thus, sleep appears to have a direct protective effect on a key protein that drives AD pathology. Science , this issue p. 880 ; see also p. 813
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“Chronic sleep deprivation was shown to enhance Aβ plaque deposition and pathological tau spreading in mice [420].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [420]
In the citing paper
“A recent study shows that tau levels in mouse ISF and human CSF are higher during normal wakefulness versus sleep. Chronic SD increases pathological tau spreading in mice. In addition, chemogenetic induction of wake states in mice significantly increases both ISF Aβ and tau [420].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [420]
In the citing paper
“amyloid-ß, tau and α-synuclein are all present at higher levels in the brain extracellular fluid and CSF during wakefulness than during sleep, and sleep deprivation increases their levels further (106–108).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [108]
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“In that regard, recent advances in neuroimaging have provided multiple approaches to map the human glymphatic system, and hence to assess its functional competence in the context of disease, as well as of the effects thereof on sleep-dependent glymphatic cyclicity (72, 73, 108).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [108]
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Cites
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Transmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Self-citationPropagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427
Tau pathology and neurodegeneration
Spillantini, M. G., & Goedert, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70090-5 · Cited by 1,133
Trans-Synaptic Spread of Tau Pathology In Vivo
Liu, L., Drouet, V., Wu, J., Witter, M. P., Small, S. A., Clelland, C. L. T., & Duff, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031302 · Cited by 994
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880
Self-citationVyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · cited 1×
“As neuronal synaptic strength/connectivity is higher during wakefulness than during sleep (11, 12), we asked whether tau levels in the brain interstitial fluid (ISF) varied with the sleep-wake cycle.”
BackgroundNeuronal activity enhances tau propagation and tau pathology in vivo
Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4328 · Cited by 820
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
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Sorted by citations
Items 201–300 of 817
Stolicyn, A., Lyall, L. M., Lyall, D. M., Høier, N. K., Adams, M. J., Shen, X., Cole, J. H., McIntosh, A. M., Whalley, H. C., & Smıth, D. J. (2023) · SLEEP · doi:10.1093/sleep/zsad274 · Cited by 36
The glymphatic system and multiple sclerosis: An evolving connection
Alghanimy, A., Work, L. M., & Holmes, W. M. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105456 · Cited by 39
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Han, F., Lee, J., Chen, X., Ziontz, J., Ward, T. J., Landau, S. M., Baker, S. L., Harrison, T. M., Jagust, W. J., & Initiative, A. D. N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14296 · Cited by 42
Havekes, R., Heckman, P. R. A., Wams, E. J., Stasiukonytė, N., Meerlo, P., & Eisel, U. L. M. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109420 · Cited by 35
Blattner, M. S., Panigrahi, S. K., Toedebusch, C. D., Hicks, T. J., McLeland, J., Banks, I. R., Schaibley, C., Ovod, V., Mawuenyega, K. G., Bateman, R. J., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191122 · Cited by 34
Self-citationRethinking the Conditions and Mechanism for Glymphatic Clearance
Ferris, C. F. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.624690 · Cited by 36
Carroll, C. M., & Macauley, S. L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00258 · Cited by 32
Jagirdar, R., Fu, C.-H., Park, J., Corbett, B. F., Seibt, F., Beierlein, M., & Chin, J. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abh4284 · Cited by 33
Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats
Zhu, J., Chen, C., Wu, J., He, M., Li, S., Fang, Y., Zhou, Y., Xu, H., Sadigh‐Eteghad, S., Manyande, A., et al. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.05.025 · Cited by 32
Xin, M., Bi, F., Wang, C., Huang, Y., Xu, Y., Liang, S., Cai, T., Xu, X., Dong, L., Li, T., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.005 · Cited by 35
Self-citationActivity- and sleep-dependent regulation of tonic inhibition by Shisa7
Wu, K., Han, W., Tian, Q., Li, Y., & Lü, W. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108899 · Cited by 34
Byron, N., Semenova, A., & Sakata, S. (2021) · Biology · doi:10.3390/biology10080707 · Cited by 32
Congdon, E. E., Pan, R., Jiang, Y., Sandusky‐Beltran, L. A., Dodge, A., Lin, Y., Liu, M., Kuo, M., Kong, X., & Sigurdsson, E. M. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104249 · Cited by 33
Sulkava, S., Haukka, J. K., Sulkava, R. O., Laatikainen, T. K., & Paunio, T. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.47115 · Cited by 34
Shoob, S., Buchbinder, N., Shinikamin, O., Gold, O., Baeloha, H., Langberg, T., Zarhin, D., Shapira, I., Braun, G., Habib, N., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42721-5 · Cited by 33
Zhang, Y., Miao, Y., Xiong, X., Tan, J., Han, Z., Chen, F., Lei, P., & Zhang, Q. (2023) · Biology Direct · doi:10.1186/s13062-023-00387-5 · Cited by 34
Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review
Xiao, X., Rui, Y., Jin, Y., & Chen, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04086-5 · Cited by 35
Carpi, M., Mercuri, N. B., & Liguori, C. (2024) · Drugs · doi:10.1007/s40265-024-02096-3 · Cited by 35
Perampanel Inhibits α‐Synuclein Transmission in Parkinson's Disease Models
Ueda, J., Uemura, N., Sawamura, M., Taguchi, T., Ikuno, M., Kaji, S., Taruno, Y., Matsuzawa, S., Yamakado, H., & Takahashi, R. (2021) · Movement Disorders · doi:10.1002/mds.28558 · Cited by 32
Challenges and Opportunities for Applying Wearable Technology to Sleep
Tobin, S. Y., Williams, P., Baron, K. G., Halliday, T. M., & Depner, C. M. (2021) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2021.07.002 · Cited by 34
Current Alzheimer disease research highlights: evidence for novel risk factors
Brenowitz, W. D., Xiang, Y., McEvoy, C. T., Yang, C., Yaffe, K. S., Le, W., & Leng, Y. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001706 · Cited by 33
Glymphatic clearance is enhanced during sleep
Kroesbergen, E., Riesselmann, L. V., Gomolka, R. S., Plá, V., Esmail, T., Stenmo, V. H., Kovács, E. R., Nielsen, E. S., Goldman, S. A., Nedergaard, M., et al. (2024) · doi:10.1101/2024.08.24.609514 · Cited by 32
Han, F., Liu, X., Yang, Y., & Liu, X. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120905 · Cited by 47
Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum
Ferini‐Strambi, L., Liguori, C., Lucey, B. P., Mander, B. A., Spira, A. P., Videnović, A., Baumann, C. R., Franco, O. H., Fernandes, M., Gnarra, O., et al. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07232-7 · Cited by 34
Self-citationGrizzanti, J., Moritz, W. R., Pait, M. C., Stanley, M., Kaye, S. D., Carroll, C. M., Constantino, N. J., Deitelzweig, L. J., Snipes, J. A., Kellar, D., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.162454 · Cited by 32
Self-citationLópez‐García, S., Lage, C., Pozueta, A., García‐Martínez, M., Kazimierczak, M., Fernández-Rodríguez, A., Bravo, M., Reyes-González, L., Irure, J., López‐Hoyos, M., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.663446 · Cited by 27
Zarhin, D., Atsmon, R., Ruggiero, A., Baeloha, H., Shoob, S., Scharf, O., Heim, L. R., Buchbinder, N., Shinikamin, O., Shapira, I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110268 · Cited by 32
Altered amyloid-β and tau proteins in neural-derived plasma exosomes in obstructive sleep apnea
Sun, H., Gao, Y., Li, M., Zhang, S., Shen, T., Yuan, X., Shang, X., Li, Z., & Zhang, J. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.03.021 · Cited by 30
Shirolapov, I. V., Zakharov, A. V., Smirnova, D. A., Lyamin, A. V., & Gayduk, A. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01585-y · Cited by 29
Chen, G., Yang, K. Y., Du, W., Hu, X., & Han, Y. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190501 · Cited by 30
Liu, R., Tang, S. H., Wang, Y., Dong, Y., Hou, T., Ren, Y., Cong, L., Liu, K., Qin, Y., Sindi, S., et al. (2022) · BMC Neurology · doi:10.1186/s12883-021-02521-0 · Cited by 29
Hebisch, M., Klostermeier, S., Wolf, K., Boccaccini, A. R., Wolf, S. E., Tanzi, R. E., & Kim, D. Y. (2023) · Advanced Science · doi:10.1002/advs.202205037 · Cited by 31
Zhu, J., Chen, C., Li, Z., Liu, X., He, J., Zhao, Z., He, M., Nie, B., Liu, Z., Chen, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371370 · Cited by 28
Ourry, V., Binette, A. P., St‐Onge, F., Strikwerda‐Brown, C., Chagnot, A., Poirier, J., Breitner, J. C. S., Arenaza‐Urquijo, E. M., Rabin, J. S., Buckley, R. F., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.09.003 · Cited by 30
Hanert, A., Schönfeld, R., Weber, F. D., Nowak, A., Döhring, J., Philippen, S., Granert, O., Burgalossi, A., Jan Born, A., Berg, D., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106378 · Cited by 34
Pait, M. C., Kaye, S. D., Su, Y., Kumar, A., Singh, S., Gironda, S. C., Vincent, S., Anwar, M., Carroll, C. M., Snipes, J. A., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12398 · Cited by 29
Kukkonen, J. P., Jacobson, L. H., Hoyer, D., Rinne, M. K., & Borgland, S. L. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.000953 · Cited by 33
Bonnar, O., Eyre, B., & van Veluw, S. J. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00535 · Cited by 32
Yang, Z., Williams, S. D., Beldzik, E., Anakwe, S. U., Schimmelpfennig, E., & Lewis, L. D. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02098-8 · Cited by 32
Tau in the brain interstitial fluid is fragmented and seeding–competent
Barini, E., Plotzky, G., Mordashova, Y., Hoppe, J., Rodriguez-Correa, E., Julier, S., Prieult, F. L., Mairhofer, I., Mezler, M., Biesinger, S., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.09.013 · Cited by 28
Zhou, H., Li, H., Gowravaram, N., Quan, M., Kausar, N., & Gomperts, S. N. (2022) · Scientific Reports · doi:10.1038/s41598-022-25364-2 · Cited by 29
The state of brain activity modulates cerebrospinal fluid transport
Miyakoshi, L. M., Stæger, F. F., Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A., et al. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102512 · Cited by 27
Sex and Sleep Disruption as Contributing Factors in Alzheimer’s Disease
Johnson, C. E., Duncan, M. J., & Murphy, M. P. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230527 · Cited by 34
Ramirez, J., Berberian, S. A., Breen, D. P., Gao, F., Ozzoude, M., Adamo, S. M., Scott, C. J. M., Berezuk, C., Yhap, V., Mestre, T., et al. (2022) · Movement Disorders · doi:10.1002/mds.29010 · Cited by 27
Sleep–Wake Disorders in Alzheimer’s Disease: A Review
Sun, Y.-Y., Wang, Z., Zhou, H.-Y., & Huang, H. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00097 · Cited by 27
van der Thiel, M. M., Backes, W. H., Ramakers, I. H. G. B., & Jansen, J. F. A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104999 · Cited by 30
Predicting Alzheimer's disease CSF core biomarkers: a multimodal Machine Learning approach
Gaeta, A. M., Quijada-López, M., Barbé, F., Vaca, R., Pujol, M., Mínguez, O., Sánchez‐de‐la‐Torre, M., Muñoz‐Barrutia, A., & Piñol‐Ripoll, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1369545 · Cited by 30
Sleep disturbance and cognition in the elderly: a narrative review
Ni, Y., Yu, M., & Liu, C. (2024) · Anesthesiology and Perioperative Science · doi:10.1007/s44254-024-00066-2 · Cited by 28
Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship
Antelmi, E., Lanza, G., Mogavero, M. P., Mingolla, G. P., Plazzi, G., Ferini‐Strambi, L., Ferri, R., & Tinazzi, M. (2024) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.14254 · Cited by 29
Alfini, A. J., Albert, M., Faria, A. V., Soldan, A., Pettigrew, C. A., Wanigatunga, S., Zipunnikov, V., & Spira, A. P. (2021) · SLEEP Advances · doi:10.1093/sleepadvances/zpab007 · Cited by 28
Zhen, Z., Guo, M., Li, H.-M., Guo, O., Zhen, J., Fu, J., & Tan, G.-J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.683483 · Cited by 27
Sleep pattern, healthy lifestyle and colorectal cancer incidence
Chen, J., Chen, N., Huang, T., Huang, N., Zhuang, Z., & Liang, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-21879-w · Cited by 26
Zhao, N., 东南大学医学院神经内科, 江. 南. 2., Xiu, C., Chen, Q.-G., Liu, X.-T., Geng, F., Zhu, M., Yan, F., Zhang, Z., Ren, Q., et al. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.085 · Cited by 27
Jia, L., Chen, Y., Li, H., Zhao, K., Ge, S., Wang, C., Zhao, J., Li, F., Zhang, L., & Yao, A. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02203-9 · Cited by 28
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Hulme, B., Didikoğlu, A., Bradburn, S., Robinson, A., Canal, M. M., Payton, A., Pendleton, N., & Murgatroyd, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200634 · Cited by 26
Quantification of Oscillatory Shear Stress from Reciprocating CSF Motion on 4D Flow Imaging
Yamada, S., Ito, H., Ishikawa, M., Yamamoto, K., Makoto, Y., Oshima, M., & Nozaki, K. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6941 · Cited by 25
The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target
Gao, F., Liu, T., Tuo, M., & Chi, S. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136247 · Cited by 26
Liu, C., Lee, S. H., Loewenstein, D., Galvin, J. E., Camargo, C. J., & Alperin, N. J. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13538 · Cited by 25
Poorer sleep impairs brain health at midlife
Namsrai, T., Ambikairajah, A., & Cherbuin, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-27913-9 · Cited by 26
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Yamada, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076528 · Cited by 26
Huang, L., Ou, Y., Yang, Y., Wang, Z.-T., Tan, L., & Yu, J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02553-9 · Cited by 28
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Arnés, M., Alaniz, M. E., Karam, C. S., Cho, J. D., López, G., Javitch, J. A., & Santa‐María, I. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00320 · Cited by 25
Sleep well to slow Alzheimer's progression?
Noble, W. J., & Spires‐Jones, T. L. (2019) · Science · doi:10.1126/science.aaw5583 · Cited by 27
Chen, C., Zhang, M., Wang, Z., Deng, J., Bao, Y., Shi, J., Lu, L., & Shi, L. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70096 · Cited by 24
The interplay between insomnia symptoms and Alzheimer’s disease across three main brain networks
Elberse, J. D., Saberi, A., Ahmadi, R., Changizi, M., Bi, H., Hoffstaedter, F., Mander, B. A., Eickhoff, S. B., Tahmasian, M., & Initiative, A. D. N. (2024) · SLEEP · doi:10.1093/sleep/zsae145 · Cited by 25
Parhizkar, S., Bao, X., Chen, W., Rensing, N. R., Chen, Y., Kipnis, M., Song, S., Gent, G., Tycksen, E., Manis, M., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01966-7 · Cited by 27
Self-citationSleep, 24-h activity rhythms, and plasma markers of neurodegenerative disease
Lysen, T. S., Ikram, M. A., Ghanbari, M., & Luik, A. I. (2020) · Scientific Reports · doi:10.1038/s41598-020-77830-4 · Cited by 24
DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer’s Disease
Chyr, J., Gong, H., & Zhou, X. (2022) · Biomolecules · doi:10.3390/biom12020196 · Cited by 24
Wang, Y., Mei, P.-C., Bai, P.-R., An, N., He, J., Wang, J., Zhu, Q., & Feng, Y. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.340691 · Cited by 23
Satpati, A., Neylan, T. C., & Grinberg, L. T. (2023) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12379 · Cited by 25
Warfield, A. E., Gupta, P., Ruhmann, M. M., Jeffs, Q. L., Guidone, G. C., Rhymes, H. W., Thompson, M. I., & Todd, W. D. (2023) · Nature Communications · doi:10.1038/s41467-023-40546-w · Cited by 31
André, C., Lanièpce, A., Chételat, G., & Rauchs, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101252 · Cited by 30
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Komaroff, A. L. (2021) · JAMA · doi:10.1001/jama.2021.5631 · Cited by 27
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Castellani, R. J., Plascencia‐Villa, G., & Perry, G. L. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_162 · Cited by 24
McGeachan, R. I., Meftah, S., Taylor, L. W., Catterson, J. H., Negro, D., Bonthron, C., Holt, K., Tulloch, J., Rose, J. L., Gobbo, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58879-z · Cited by 23
Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution
Wafford, K. A. (2021) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2021.100025 · Cited by 25
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Ba, L., Huang, L., He, Z., Deng, S., Xie, Y., Zhang, M., Jacob, C., Antonecchia, E., Liu, Y., Xiao, W., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.759983 · Cited by 27
Xiong, X., Hu, T., Yin, Z., Zhang, Y., Chen, F., & Lei, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.944283 · Cited by 26
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Xu, J., Su, Y., Fu, J., Shen, Y., Dong, Q., & Cheng, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101885 · Cited by 24
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Sleep profile predicts the cognitive decline of mild-moderate Alzheimer’s disease patients
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Metadata
- Authors
- Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., Lucey, B. P., & Holtzman, D. M.
- Affiliations
- Washington University in St. Louis (US)
- Emory University (US)
- University of Iowa Hospitals and Clinics (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Holth, Jerrah K.
- Fritschi, Sarah K.
- Holtzman, David M.
- ORCID
- Venue
- Science
- Published
- 2019-02-22
- Volume
- 363
- Issue
- 6429
- Pages
- 880-884
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6410369
- OpenAlex
- W2912003143
- Cited by
- 813
- References
- 33
- Citations by year
- 2026: 117 · 2025: 121 · 2024: 128 · 2023: 115 · 2022: 98 · 2021: 98 · 2020: 87 · 2019: 49
- FWCI
- 56.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (AG047999, AG054863, AG05681, AG26276)
- National Institute of Neurological Disorders and Stroke (NS074969, NS073613, K08NS105929, NS089381)
- National Center for Advancing Translational Sciences (TR000448, TR000450)
- BrightFocus Foundation (A2017114F)
- Deutsche Forschungsgemeinschaft (3625/1-1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Keywords
- sleep-wake cycle, tau protein, cerebrospinal fluid, interstitial fluid, chronic sleep deprivation, Alzheimer's disease, amyloid-beta, tau pathology
- MeSH terms
- Animals, Brain, Circadian Rhythm, Female, Male, Mice, Transgenic, Sleep, Sleep Deprivation, Wakefulness, Amyloid beta-Peptides, tau Proteins, Extracellular Fluid, Mice
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