Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

Leone, Robert D., Zhao, Liang, Englert, Judson M., Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Arwood, Matthew L., Bettencourt, Ian A., Patel, Chirag H., Wen, Jiayu, Tam, Ada, Blosser, Richard L., Prchalova, Eva, Alt, Jesse, Rais, Rana, Slusher, Barbara S., Powell, Jonathan D.·2019·Science

DOI 10.1126/science.aav2588

Cited by (1,001)

Items 301–400 of 1,001

Immunometabolism – The Role of Branched-Chain Amino Acids
Berkay Yahsi, Gürcan Günaydın · 2022 · Frontiers in Immunology
Unbalanced Glutamine Partitioning between CD8T Cells and Cancer Cells Accompanied by Immune Cell Dysfunction in Hepatocellular Carcinoma
Jianfei Chen, Rui Wang, Zhongliang Liu, Jun Fan, Shenglu Liu, Shunde Tan, Xinkai Li, Bo Li, Xiaoli Yang · 2022 · Cells
Micro-engineering and nano-engineering approaches to investigate tumour ecosystems
Mijin Kim, Magdalini Panagiotakopoulou, Chen Chen, Stephen B. Ruiz, Karuna Ganesh, Tuomas Tammela, Daniel A. Heller · 2023 · Nature reviews. Cancer
Tumor‐Targeted Glutamine Metabolism Blocker Synergizes with TiO 2 ‐Au Janus Nanoparticles for Enhanced Sono‐Metabolic Antitumor Therapy
Jinling Zheng, Fenghuan Zhao, Eugénie Pariente, Xiaoyu Xu, Xu Zhang, Shayibai Shabiti, Yingying Ke, Junjie Hao, Jean-Pierre DELVILLE, Marie‐Hélène Delville et al. · 2025 · Advanced Materials
Tuberculosis endotypes to guide stratified host-directed therapy
Andrew R. DiNardo, Tomoki Nishiguchi, Sandra L. Grimm, Larry S. Schlesinger, Edward A. Graviss, Jeffrey D. Cirillo, Cristian Coarfa, Anna Maria Mandalakas, Jan Heyckendorf, Stefan H. E. Kaufmann et al. · 2021 · Med
The Role of Metabolic Enzymes in the Regulation of Inflammation
Wesley H. Godfrey, Michael D. Kornberg · 2020 · Metabolites
Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer
Prameela Kandra, Rajender Nandigama, Bastian G. Eul, Magdalena Huber, Sebastian Kobold, Werner Seeger, Friedrich Grimminger, Rajkumar Savai · 2022 · Frontiers in Immunology
Efferocytosis by macrophages in physiological and pathological conditions: regulatory pathways and molecular mechanisms
Yan‐Ran Sheng, Wenting Hu, Siman Chen, Xiao‐Yong Zhu · 2024 · Frontiers in Immunology
Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy
Huiru Zhang, Jigeng Fan, Deyang Kong, Yu Sun, Qi Zhang, Renshen Xiang, Shuaibing Lu, Wenjing Yang, Lin Feng, Haizeng Zhang · 2025 · Molecular Cancer
Therapeutic potential of NR4A1 in cancer: Focus on metabolism
Shan Deng, Bo Chen, Jiege Huo, Xin Liu · 2022 · Frontiers in Oncology
New opportunities for immunomodulation of the tumour microenvironment using chemical tools
Jingyun Su, Wenhao Li, Yanmei Li · 2022 · Chemical Society Reviews
The Role of Tumor Metabolic Reprogramming in Tumor Immunity
Xianhong Zhang, Weiguo Song, Yue Gao, Yu Zhang, Yuqi Zhao, Shuailin Hao, Ting Ni · 2023 · International Journal of Molecular Sciences
Metabolites as agents and targets for cancer immunotherapy
Marcel P. Trefny, Guido Kroemer, Laurence Zitvogel, Sebastian Kobold · 2025 · Nature Reviews Drug Discovery
HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
Xin Guo, Aman Wang, Wen Wang, Ya Wang, Huan Chen, Xiaolong Liu, Tian Xia, Aijia Zhang, Di Chen, Huan Qi et al. · 2020 · Molecular Oncology
A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer
Jingjing Wang, Michelle Kwan-Yee Siu, Yuxin Jiang, Thomas Ho-Yin Leung, David W. Chan, Huogang Wang, Hys Ngan, Karen K. L. Chan · 2021 · Biomolecules
Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment
Tanner J. Wetzel, Sheila C. Erfan, Lucas D. Figueroa, Leighton M. Wheeler, Elitsa Antonova Ananieva · 2023 · Frontiers in Oncology
T cell-based cancer immunotherapy: opportunities and challenges
Kaili Ma, Yingxi Xu, Hongcheng Cheng, Ke Tang, Jingwei Ma, Bo Huang · 2025 · 中国科学通报：英文版
Nanomedicine strategies for cuproptosis: Metabolic reprogramming and tumor immunotherapy
Ruixuan Zhang, Yunfei Li, Hui Fu, Chengcheng Zhao, Xiuyan Li, Yuming Wang, Yujiao Sun, Yingpeng Li · 2025 · Acta Pharmaceutica Sinica B
Targeted Glucose or Glutamine Metabolic Therapy Combined With PD-1/PD-L1 Checkpoint Blockade Immunotherapy for the Treatment of Tumors - Mechanisms and Strategies
Guofeng Ma, Chun Li, Zhilei Zhang, Ye Liang, Zhijuan Liang, Yuanbin Chen, Liping Wang, Dan Li, Manqin Zeng, Wenhong Shan et al. · 2021 · Frontiers in Oncology
Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting
Ryan D. Sheldon, Eric H. Ma, Lisa M. DeCamp, Kelsey S. Williams, Russell G. Jones · 2021 · Nature Protocols
Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma
Yike Wan, Mengping Chen, Xin Li, Xiaofeng Han, Lu Zhong, Fei Xiao, Jia Liu, Jing Xiang, Jinxing Jiang, Xiaotong Chen et al. · 2023 · Cancer Letters
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis
Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin N. Koleske, Robert D. Leone, Rana Rais, Jonathan D. Powell, John R. Murphy et al. · 2023 · Nature Communications
Nutrient inputs and social metabolic control of T cell fate
Zachary A. Bacigalupa, Madelyn D. Landis, Jeffrey C. Rathmell · 2023 · Cell Metabolism
Metabolic Reprogramming Induces Immune Cell Dysfunction in the Tumor Microenvironment of Multiple Myeloma
Shaojie Wu, Huixian Kuang, Jin Ke, Manfei Pi, Dong‐Hua Yang · 2021 · Frontiers in Oncology
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis
Shagun Sharma, Navneet Agnihotri, Sandeep Kumar · 2022 · Biochemical Pharmacology
Metabolic Reprogramming in Hematologic Malignancies: Advances and Clinical Perspectives
Zhuoya Yu, Xiangxiang Zhou, Xin Wang · 2022 · Cancer Research
Manipulating T-cell metabolism to enhance immunotherapy in solid tumor
Chen Chen, Zehua Wang, Yi Ding, Yanru Qin · 2022 · Frontiers in Immunology
Metabolites and Immune Response in Tumor Microenvironments
Salvatore Cortellino, Valter Daniel Longo · 2023 · Cancers
Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus
Quanyuan Wan, Leah Tavakoli, Ting‐Yu Wang, Andrew J. Tucker, Ruiting Zhou, Qizhi Liu, Shu Feng, Dongwon Choi, Zhiheng He, Michaela U. Gack et al. · 2024 · Nature Communications
Metabolic rewiring and communication in cancer immunity
Nicole M. Chapman, Hongbo Chi · 2024 · Cell chemical biology
Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis
Zhaobing Ding, Russell Erick Ericksen, Qian Yi Lee, Weiping Han · 2021 · Amino Acids
Barriers to Immunotherapy in Ovarian Cancer: Metabolic, Genomic, and Immune Perturbations in the Tumour Microenvironment
Racheal Louise Johnson, Michele Cummings, Amudha Thangavelu, Georgios Theophilou, Diederick De Jong, Nicolas Michel Orsi · 2021 · Cancers
Metabolic adaptation of NK cell activity and behavior in tumors: challenges and therapeutic opportunities
Shambhavi Borde, Sandro Matosevic · 2023 · Trends in Pharmacological Sciences
Metabolic advantages of regulatory T cells dictated by cancer cells
Masaki Kondo, Shogo Kumagai, Hiroyoshi Nishikawa · 2023 · International Immunology
New insights into immune cells in cancer immunotherapy: from epigenetic modification, metabolic modulation to cell communication
Sha Qin, Bin Xie, Qingyi Wang, Rui Yang, Jingyue Sun, Chaotao Hu, Shuang Liu, Yongguang Tao, Desheng Xiao · 2024 · MedComm
Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity
Jian Gu, Li Yu, Qiuyang Chen, Ziyan Song, Qufei Qian, Yuan Liang, Tianning Huang, Lei Qiao, Xiangyu Li, Mei Yu et al. · 2025 · Cell
Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism
Torahito A. Gao, Yvonne Y. Chen · 2022 · Annual Review of Chemical and Biomolecular Engineering
Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment
Fan, Yuxin, Xue, Han, Li, Zhimin, Huo, Mingge, Gao, Hongxia, Guan, Xingang · 2024 · Frontiers in Pharmacology
How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications
Heleen H. Van Acker, Shixin Ma, Tommaso Scolaro, Susan M. Kaech, Massimiliano Mazzone · 2021 · Trends in Immunology
Targeting allosteric regulation of cancer metabolism
Daniel M. Kremer, Costas Andreas Lyssiotis · 2022 · Nature Chemical Biology
Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization
Wei Li, Qingwen Zeng, Bing Wang, Chao Lv, Haoan He, Xi Yang, Bin Cheng, Xiaoan Tao · 2024 · Redox Biology
Implications of metabolism-driven myeloid dysfunctions in cancer therapy
Laura Strauss, Valentina Guarneri, Alessandra Gennari, Antonio Sica · 2020 · Cellular and Molecular Immunology
Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy
Ashley N. Pearson, Joseph Carmicheal, Long Jiang, Yu L. Lei, Michael D. Green · 2021 · International Journal of Molecular Sciences
Blocking Cholesterol Metabolism with Tumor‐Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy
Xiaochen Liu, Zitong Zhao, Xiangshi Sun, Jue Wang, Wenzhe Yi, Dangge Wang, Yaping Li · 2022 · Small Methods
Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis via Inhibiting T Cell Activation and Differentiation
Qiang Yu, Honghu Tu, Xueyi Yin, Chang Peng, Chuanyun Dou, Wenhua Yang, Wen‐Biao Wu, Xiaotong Guan, Jia Xuan Li, Hexin Yan et al. · 2022 · Frontiers in Immunology
Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications
Ishita Gupta, Ola Hussein, Konduru Seetharama Sastry, Salim Bougarn, Neha Gopinath, Evonne C. Chin-Smith, Yashi Sinha, Hesham Mohamed Korashy, Cristina Maccalli · 2023 · Advances in Cancer Biology - Metastasis
Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead
Xuwen Li, Tao Sun, Chen Jiang · 2023 · Advanced Materials
Immunotherapeutic strategies in head and neck cancer: challenges and opportunities
Xia Liu, R. Alex Harbison, Mark Alex Varvares, Sidharth V. Puram, Guangyong Peng · 2025 · Journal of Clinical Investigation
Attenuating Metabolic Competition of Tumor Cells for Favoring the Nutritional Demand of Immune Cells by a Branched Polymeric Drug Delivery System
Yinggang Li, Zhenyu Duan, Dayi Pan, Long Fang Ren, Lei Gu, Xiaoling Li, Gang Xu, Hongyan Zhu, Hu Zhang, Zhongwei Gu et al. · 2022 · Advanced Materials
Immunoregulation in cancer-associated cachexia
Qi Wu, Zhou Liu, Bei Li, Yue Liu, Ping Wang · 2023 · Journal of Advanced Research
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
Mahboubeh Tajaldini, Amirhoushang Poorkhani, Taghi Amiriani, Amirhossein Amiriani, Hossein Javid, Parham Aref, Farahnazsadat Ahmadi, Somayeh Sadani, Vahid Khori · 2023 · European Journal of Pharmacology
Revisiting the biological role of the Warburg effect: Evolving perspectives on cancer metabolism
Diego De León-Oliva, Paula González-Prieto, Patricia De Castro-Martinez, Diego Liviu Boaru, Pilar Laguna Hernandez, Oscar Fraile‐Μartinez, Cielo García Montero, Luis G. Guijarro, Laura López-González, Raúl Díaz et al. · 2025 · Pathology - Research and Practice
Advances into understanding metabolites as signaling molecules in cancer progression
Joyce Y. Liu, Kathryn E. Wellen · 2020 · Current Opinion in Cell Biology
Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer
Raj Shah, Suzie Chen · 2020 · Cancers
Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Avinash D Sahu, Xiaoman Wang, Phillip B. Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Gege Qian, Phillip Nicol, Zexian Zeng, Chenfei Wang et al. · 2023 · Cancer Discovery
D-Amino Acids and Cancer: Friends or Foes?
Giulia Murtas, Loredano Pollegioni · 2023 · International Journal of Molecular Sciences
Resistance to immune checkpoint inhibitors in gastric cancer
Kai Liu, Shiman Yuan, Chenyu Wang, Hong Zhu · 2023 · Frontiers in Pharmacology
YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner
Yicun Han, Yunzhou Pu, Xiaodie Liu, Zhiyi Liu, Yongqi Chen, Lei Tang, Jing Zhou, Qing Song, Qing Ji · 2024 · Cancer Letters
Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies
Jie Jiang, Yan Yan, Chunhui Yang, Hong Cai · 2025 · Biomedicines
Metabolic Reprogramming of Glycolysis, Lipids, and Amino Acids in Tumors: Impact on CD8 + T Cell Function and Targeted Therapeutic Strategies
Panping Liang, Zedong Li, Zhengwen Chen, Zehua Chen, Tao Jin, Fengjun He, Xiaolong Chen, Hongfeng Gou, Kun Yang · 2025 · The FASEB Journal
Metabolic Strategies for Inhibiting Cancer Development
Philippe Icard, Mauro Loi, Zherui Wu, Antonin Ginguay, Hubert Lincet, Edouard Robin, Antoine Coquerel, Diana Berzan, Ludovic Fournel, Marco Alifano · 2020 · Advances in Nutrition
Metabolic Molecule PLA2G2D Is a Potential Prognostic Biomarker Correlating With Immune Cell Infiltration and the Expression of Immune Checkpoint Genes in Cervical Squamous Cell Carcinoma
Hong Liu, Ruiyi Xu, Chun Gao, Tong Zhu, Li‐Ting Liu, Yifan Yang, Haihong Zeng, Yafei Huang, Hui Wang · 2021 · Frontiers in Oncology
Engineered NK Cells Against Cancer and Their Potential Applications Beyond
Maria Karvouni, Marcos Vidal-Manrique, Andreas Lundqvist, Evren Alici · 2022 · Frontiers in Immunology
Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers
Shih‐Han Hsu, Wen‐Chun Hung · 2022 · Cancer Letters
Immunometabolic reprogramming, another cancer hallmark
Vijay Kumar, John H. Stewart · 2023 · Frontiers in Immunology
Circulating and Tumor-Associated Neutrophils in the Era of Immune Checkpoint Inhibitors: Dynamics, Phenotypes, Metabolism, and Functions
Lara Gibellini, Rebecca Borella, Elena Santacroce, Eugenia Serattini, Federica Boraldi, Daniela Quaglino, Beatrice Aramini, Sara De Biasi, Andrea Cossarizza · 2023 · Cancers
CAR-T therapy and targeted treatments: Emerging combination strategies in solid tumors
Jiahao Liu, Xiaofei Jiao, Ding Ma, Yong Fang, Qinglei Gao · 2024 · Med
Targeting tumor metabolism to augment CD8+ T cell anti-tumor immunity
Huan Liu, Wenyong Yang, Jingwen Jiang · 2024 · Journal of Pharmaceutical Analysis
The Ups and Downs of Metabolism during the Lifespan of a T Cell
Renu Balyan, Namrata Gautam, Nicholas R. J. Gascoigne · 2020 · International Journal of Molecular Sciences
Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma
Yongmei Feng, Gaurav Pathria, Susanne Heynen‐Genel, Michael Jackson, Brian P. James, Jun Yin, David A. Scott, Ze’ev A. Ronai · 2021 · Molecular Cancer Therapeutics
Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance
Javier Traba, Michael N. Sack, Thomas A. Waldmann, Olga M. Antón · 2021 · Frontiers in Immunology
Inhibition of GFAT1 in lung cancer cells destabilizes PD-L1 protein
Wenshu Chen, Bryanna Saxton, Mathewos Tessema, Steven A. Belinsky · 2021 · Carcinogenesis
Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review
Dong Wang, Xin Wan · 2022 · Biomedicine & Pharmacotherapy
Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
Lisha Bao, Tong Xu, Xixuan Lu, Ping Cheong Huang, Zongfu Pan, Minghua Ge · 2021 · Frontiers in Oncology
CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling
Ai Chen, Xiao Yan Sun, Shan Xiao, Lu Guo, Mengmeng Shang, Dandan Shi, Dong Meng, Yading Zhao, Xiaoxuan Wang, Jie Li · 2023 · Journal of Nanobiotechnology
QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
Leonard R. Pelgrom, Gavin M. Davis, Simon O’Shaughnessy, Emilie J.M. Wezenberg, Sander I. van Kasteren, David K. Finlay, Linda V. Sinclair · 2023 · Cell Reports
Glutaminase inhibition as potential cancer therapeutics: current status and future applications
Rajath Cyriac, Kwang‐Ho Lee · 2023 · Journal of Enzyme Inhibition and Medicinal Chemistry
Tumor microenvironment as niche constructed by cancer stem cells: Breaking the ecosystem to combat cancer
Hao Zhong, Shiyue Zhou, Shuangshuang Yin, Yuling Qiu, Bo Liu, Haiyang Yu · 2024 · Journal of Advanced Research
Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin Raynard Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis et al. · 2021 · Cancer Research
Glutamine deprivation induces ferroptosis in pancreatic cancer cells
Zhiwen Xiao, Shengming Deng, He Liu, Ruijie Wang, Yu Liu, Zhengjie Dai, Wenchao Gu, Quanxing Ni, Xianjun Yu, Chen Liu et al. · 2023 · Acta Biochimica et Biophysica Sinica
Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment
Chunxue Yang, Derek Lee, Misty Shuo Zhang, Aki Pui‐Wah Tse, Lai Wei, Macus Hao‐Ran Bao, Bowie Po‐Yee Wong, Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, Yi‐Ling Chen et al. · 2022 · Advanced Science
SCD1 inhibition enhances the effector functions of CD8 + T cells via ACAT1 ‐dependent reduction of esterified cholesterol
Toshihiro Sugi, Yuki Katoh, Toshikatsu Ikeda, Daichi Seta, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Kanoko Katoh, Kei Kawana et al. · 2023 · Cancer Science
Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy
Tjaša Frlic, Mojca Pavlin · 2025 · Frontiers in Immunology
G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes
Chunwan Lu, Dafeng Yang, John David Klement, Yolonda Lorig Colson, Nicholas H. Oberlies, Cedric J. Pearce, Aaron H. Colby, Mark W. Grinstaff, Han‐Fei Ding, Huidong Shi et al. · 2022 · Journal for ImmunoTherapy of Cancer
Pathogenetic mechanisms and treatment targets in cerebral malaria
Alexandros Hadjilaou, Johannes Brandi, Mathias Riehn, Manuel Alexander Friese, Thomas Jacobs · 2023 · Nature Reviews Neurology
Deciphering the Warburg Effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation
Albert Mao Li, Jiangbin Ye · 2023 · Annual Review of Cancer Biology
Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy
Seon Ah Lim · 2024 · BMB Reports
Targeting amino acid-metabolizing enzymes for cancer immunotherapy
Yvonne Grobben · 2024 · Frontiers in Immunology
Tumor energy metabolism: implications for therapeutic targets
Youwu Hu, Wanqing Liu, WanDi Fang, Yudi Dong, Hong Zhang, Qing Luo · 2024 · Molecular Biomedicine
Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
Xuqing Shen, Yueyue Chen, Yingying Tang, Ping Lu, Mingzhu Liu, Tiebo Mao, Yawen Weng, Feier Yu, Yimei Liu, Yujie Tang et al. · 2025 · Cell Reports Medicine
Photochemical Generation of Peroxynitrite: Concurrent Inhibition of Glycolysis and Glutamine Metabolism for Enhanced Metabolic Therapy
Lizhen Yuan, Liang Yang, Wen Long Song, Haoyang Song, Jingjing Hu, Xiaoding Lou, Fan Xia, Juyoung Yoon · 2025 · Journal of the American Chemical Society
Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers
Juan Carlos García‐Cañaveras, Agustín Lahoz · 2021 · Cancers
HIF in Gastric Cancer: Regulation and Therapeutic Target
Mengqing Li, Li Guan, Xiaodong Yang, Weihua Yin, Guoqing Lv, Shubin Wang · 2022 · Molecules
Functional gelatin hydrogel scaffold with degraded-release of glutamine to enhance cellular energy metabolism for cartilage repair
Ran Yang, Xu Zhang, Jiahui Liu, Xiaoyuan Li, Dongfang Zhou, Shifang Luan · 2022 · International Journal of Biological Macromolecules
Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy
Yingqin Hou, Jaroslav Žák, Yujie Shi, Isaraphorn Pratumchai, Brandon Dinner, Wenjian Wang, Ke Qin, Evan W. Weber, John Ross Teijaro, Peng Wu · 2024 · Cancer Immunology Research
Ferroptosis: iron release mechanisms in the bioenergetic process
Jaewang Lee, Jong‐Lyel Roh · 2025 · Cancer and Metastasis Reviews
CCL2 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Shows Divergent Prognostic Potential for Bladder Cancer Patients Depending on Lymph Node Stage
Markus Eckstein, Elena Epple, Rudolf Jung, Katrin Weigelt, Verena Lieb, Danijel Sikic, Robert Stöhr, Carol Imanuel Geppert, Veronika Weyerer, Simone Bertz et al. · 2020 · Cancers
Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation
Hyeon Young Park, Mi Jin Kim, Seunghyeong Lee, Jonghwa Jin, Sungwoo Lee, Jung‐Guk Kim, Yeon‐Kyung Choi, Keun‐Gyu Park · 2021 · International Journal of Molecular Sciences
GOT1 regulates CD8+ effector and memory T cell generation
Wei Xu, Chirag H. Patel, Liang Zhao, Im‐Hong Sun, Min Hee Oh, Im-Meng Sun, Rachel S. Helms, Jiayu Wen, Jonathan D. Powell · 2023 · Cell Reports
Redox modulation with a perfluorocarbon nanoparticle to reverse Treg-mediated immunosuppression and enhance anti-tumor immunity
Zhaoting Li, Yueyang Deng, Honghao Sun, Caixia Tan, Heming Li, Fanyi Mo, Yixin Wang, Jing Li, Zhanwei Zhou, Minjie Sun · 2023 · Journal of Controlled Release