The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Programmable CRISPR-responsive smart materials
Open accessAbstract
A CRISPR set of materials: CRISPR technology is best known as a gene editing tool. English et al. developed a group of stimuli-responsive hydrogels to respond to the programmable nuclease Cas12a (see the Perspective by Han et al. ). The materials undergo molecular to macroscopic changes after Cas12a-dependent cleavage of double- or single-stranded DNA integrated into the gel. The authors show controlled release of particles linked to or imprisoned within the DNA, degradation of a gel with DNA solely forming the cross-links, and permeabilization of a gel with DNA partially forming the cross-links. These tools allow for the production of materials that release encapsulated nanoparticles and cells, act as degradable fuses, and enable remote radio-frequency identification signaling. Science , this issue p. 780 ; see also p. 754
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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
Chen, J. S., Ma, E., Harrington, L. B., Da Costa, M., Tian, X., Palefsky, J. M., & Doudna, J. A. (2018) · Science · doi:10.1126/science.aar6245 · Cited by 4,507
Self-Assembled Graphene Hydrogel via a One-Step Hydrothermal Process
Xu, Y., Sheng, K., Li, C., & Shi, G. (2010) · ACS Nano · doi:10.1021/nn101187z · Cited by 3,251
Designer matrices for intestinal stem cell and organoid culture
Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., Clevers, H., & Lutolf, M. P. (2016) · Nature · doi:10.1038/nature20168 · Cited by 1,426
CRISPR-Cas guides the future of genetic engineering
Knott, G. J., & Doudna, J. A. (2018) · Science · doi:10.1126/science.aat5011 · Cited by 1,410
Cited by
Kaminski, M. M., Abudayyeh, O. O., Gootenberg, J. S., Zhang, F., & Collins, J. J. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00760-7 · Cited by 1,259
Self-citationLiu, X., Liu, J., Lin, S., & Zhao, X. (2020) · Materials Today · doi:10.1016/j.mattod.2019.12.026 · Cited by 1,023
Xiong, Y., Zhang, J., Yang, Z., Mou, Q., Ma, Y., Xiong, Y., & Lu, Y. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09211 · Cited by 689
El-Husseiny, H. M., Mady, E. A., Hamabe, L., Abugomaa, A., Shimada, K., Yoshida, T., Tanaka, T., Yokoi, A., Elbadawy, M., & Tanaka, R. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100186 · Cited by 533
CRISPR-Cas12a: Functional overview and applications
Paul, B., & Montoya, G. (2020) · Biomedical Journal · doi:10.1016/j.bj.2019.10.005 · Cited by 409
Metadata
- Authors
- English, M. A., Soenksen, L. R., Gayet, R. V., de Puig, H., Angenent-Mari, N. M., Mao, A. S., Nguyen, P. Q., & Collins, J. J.
- Venue
- Science
- Published
- 2019-08-23
- Volume
- 365
- Issue
- 6455
- Pages
- 780-785
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2969221202
- Cited by
- 356
- References
- 4
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
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