The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
Open accessAbstract
Placenta formation and fetal demise: A critical step of placental development is the fusion of trophoblast cells into a multi-nucleated syncytiotrophoblast layer. Trophoblast fusion is mediated by syncytins, encoded by endogenous retrovirus–derived envelope glycoproteins. Buchrieser et al. report that interferon-induced transmembrane (IFITM) proteins inhibit syncytin-mediated syncytiotrophoblast formation, restricting placental development and triggering fetal demise (see the Perspective by Kellam and Weiss). The results provide a molecular explanation for the placental dysfunctions observed in interferon-mediated disorders such as intrauterine growth retardation, TORCH (toxoplasmosis, other, rubella, cytomegalovirus, and herpes) infections, and some forms of preeclampsia. Science , this issue p. 176 ; see also p. 118
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Cites
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Trisomy 21 consistently activates the interferon response
Sullivan, K. D., Lewis, H. C., Hill, A. A., Pandey, A., Jackson, L. P., Cabral, J. M., Smith, K. P., Liggett, L. A., Gomez, E. B., Galbraith, M. D., et al. (2016) · eLife · doi:10.7554/elife.16220 · Cited by 362
IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread
Compton, A. A., Bruel, T., Porrot, F., Mallet, A., Sachse, M., Euvrard, M., Liang, C., Casartelli, N., & Schwartz, O. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.11.001 · Cited by 231
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Cited by
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Syncytia formation by SARS‐CoV‐2‐infected cells
Buchrieser, J., Dufloo, J., Hubert, M., Monel, B., Planas, D., Rajah, M. M., Planchais, C., Porrot, F., Guivel‐Benhassine, F., Van der Werf, S., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020106267 · Cited by 462
Self-citationContributions of maternal and fetal antiviral immunity in congenital disease
Yockey, L. J., Lucas, C., & Iwasaki, A. (2020) · Science · doi:10.1126/science.aaz1960 · Cited by 68
IFITM proteins assist cellular uptake of diverse linked chemotypes
Lou, K., Wassarman, D. R., Yang, T., Paung, Y., Zhang, Z., O’Loughlin, T. A., Moore, M. K., Egan, R. K., Greninger, P., Benes, C. H., et al. (2022) · Science · doi:10.1126/science.abl5829 · Cited by 42
Gao, L., Mathur, V., Tam, S. K. M., Zhou, X., Cheung, M. F., Chan, L. Y., Estrada-Gutiérrez, G., Leung, B. W., Moungmaithong, S., Wang, C. C., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01169-x · Cited by 31
Metadata
- Authors
- Buchrieser, J., Degrelle, S. A., Couderc, T., Nevers, Q., Disson, O., Manet, C., Donahue, D. A., Porrot, F., Hillion, K.-H., Perthame, E., Arroyo, M. V., Souquere, S., Ruigrok, K., Dupressoir, A., Heidmann, T., Montagutelli, X., Fournier, T., Lecuit, M., & Schwartz, O.
- Venue
- Science
- Published
- 2019-07-12
- Volume
- 365
- Issue
- 6449
- Pages
- 176-180
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2961523841
- Cited by
- 160
- References
- 4
- FWCI
- 19.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Buchrieser, J., Degrelle, S. A., Couderc, T., Nevers, Q., Disson, O., Manet, C., Donahue, D. A., Porrot, F., Hillion, K.-H., Perthame, E., Arroyo, M. V., Souquere, S., Ruigrok, K., Dupressoir, A., Heidmann, T., Montagutelli, X., Fournier, T., Lecuit, M., & Schwartz, O. (2019). IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise. Science. https://doi.org/10.1126/science.aaw7733
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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