REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories
Open accessAbstract
A brain pathway for active forgetting: Sleep affects memories via several mechanisms. Izawa et al. identified a possible new pathway in the brain: REM sleep–active hypothalamic melanin-concentrating hormone (MCH)–producing neurons, which, among others, project to the hippocampus. Surprisingly, genetic ablation of MCH neurons increased memory performance in mice. Conversely, pharmacogenetic activation of MCH neurons impaired memory. In vitro physiological experiments showed that activation of MCH fibers in hippocampal slices suppressed spiking activity of pyramidal cells. These findings indicate that the MCH pathway may become a target for memory modulation. Science , this issue p. 1308
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REM sleep active hypothalamic MCH neurons produced forgetting of hippocampal memory possibly by increasing inhibition of hippocampal pyramidal cell firing, whereas another study identified a subgroup of REM sleep active MCH neurons specifically projecting to hippocampal CA2 region, which enhanced consolidation of social memories.
“REM sleep active hypothalamic MCH neurons produced forgetting of hippocampal memory possibly by increasing inhibition of hippocampal pyramidal cell firing, 222 whereas another study identified a subgroup of REM sleep active MCH neurons specifically projecting to the hippocampal CA2 region, which enhanced consolidation of social memories.72”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [222]
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References 42 · Cited by 224
- Authors
- Izawa, S., Chowdhury, S., Miyazaki, T., Mukai, Y., Ono, D., Inoue, R., Ohmura, Y., Mizoguchi, H., Kimura, K., Yoshioka, M., Terao, A., Kilduff, T. S., & Yamanaka, A.
- Affiliations
- Japan Society for the Promotion of Science (JP)
- Japan Science and Technology Agency (JP)
- Research Institute of Environmental Medicine, Nagoya University (JP)
- Hokkaido University (JP)
- Tokai University (JP)
- SRI International (US)
- Corresponding author
- Yamanaka, Akihiro
- ORCID
- Venue
- Science
- Published
- 2019-09-20
- Volume
- 365
- Issue
- 6459
- Pages
- 1308-1313
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7378274
- OpenAlex
- W2974920122
- Semantic Scholar
- dee7b652dd26955b7aa138b839ee3869a9c784c1
- Cited by
- 224
- References
- 42
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 30 · 2023: 27 · 2022: 36 · 2021: 44 · 2020: 34 · 2019: 1
- FWCI
- 16.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Repositories DataBase (IRDB) (acceptedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Nagoya University Repository (NAGOYA Repository) (submittedVersion, cc-by-nc-nd)
- Nagoya University Repository (NAGOYA Repository) (submittedVersion)
- Funders
- MEXT, Japan (26293046, 26640041, 16H01271, 17H05563, 18H02523, 18KK0223, and 18H05124, 18J21663)
- JST, CREST (JPMJCR1656)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- melanin-concentrating hormone, REM sleep, forgetting, hippocampal-dependent memory, hypothalamus, dorsal hippocampus, inhibitory synaptic input, hippocampal pyramidal neurons
- MeSH terms
- Animals, Behavior, Animal, Hippocampus, Hypothalamic Hormones, Male, Melanins, Memory, Mice, Inbred C57BL, Mice, Transgenic, Pituitary Hormones, Sleep, REM, Pyramidal Cells, Mice, In Vitro Techniques
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