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Cited by 529Dermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisSingle-cell and spatial transcriptomics

Developmental cell programs are co-opted in inflammatory skin disease

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Reynolds, Gary, Vegh, Peter, Fletcher, James, Poyner, Elizabeth F. M., Stephenson, Emily, Goh, Issac, Botting, Rachel A., Huang, Ni +41 more·2021·Science
DOI 10.1126/science.aba6500PMC PMC7611557
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Abstract

Cellular beauty is skin deep: Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. In this atlas, gene expression in the two disease states studied—atopic dermatitis and psoriasis—varied from that in a healthy adult, suggesting that a fetal skin signature is expressed in adult inflamed skin. Furthermore, differences in immune cell composition between healthy fetal and adult skin and that of individuals suffering from disease were observed. Science , this issue p. eaba6500

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Cited by

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Authors
Reynolds, G., Vegh, P., Fletcher, J., Poyner, E. F. M., Stephenson, E., Goh, I., Botting, R. A., Huang, N., Olabi, B., Dubois, A., Dixon, D., Green, K., Maunder, D., Engelbert, J., Efremova, M., Polański, K., Jardine, L., Jones, C., Ness, T., Horsfall, D., McGrath, J., Carey, C., Popescu, D.-M., Webb, S., Wang, X.-N., Sayer, B., Park, J.-E., Negri, V. A., Belokhvostova, D., Lynch, M. D., McDonald, D., Filby, A., Hagai, T., Meyer, K. B., Husain, A., Coxhead, J., Vento-Tormo, R., Behjati, S., Lisgo, S., Villani, A.-C., Bacardit, J., Jones, P. H., O’Toole, E. A., Ogg, G. S., Rajan, N., Reynolds, N. J., Teichmann, S. A., Watt, F. M., & Haniffa, M.
Affiliations
  • Newcastle University (GB)
  • Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
  • Wellcome Sanger Institute (GB)
  • NHS Lothian (GB)
  • Guy's Hospital (GB)
  • Tel Aviv University (IL)
  • Royal Victoria Infirmary (GB)
  • Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • University of Cambridge (GB)
  • Broad Institute (US)
  • Queen Mary University of London (GB)
  • University of Oxford (GB)
Corresponding author
  • Reynolds, Gary
  • Fletcher, James
  • Poyner, Elizabeth F. M.
  • Teichmann, Sarah A.
  • Watt, Fiona M.
  • Haniffa, Muzlifah
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-01-22
Volume
371
Issue
6527
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.aba6500
PMC
PMC7611557
OpenAlex
W3124296497
Cited by
529
References
11
Citations by year
2026: 93 · 2025: 99 · 2024: 98 · 2023: 96 · 2022: 93 · 2021: 49 · 2013: 1
FWCI
74.89
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
  • Apollo (cc-by)
Funders
  • Wellcome (WT107931/Z/15/Z, WT211276/Z/18/Z, WT206194, 211276/E/18/Z, 206439/Z/17/Z, 108874/Z/15/Z, WT214539/Z/18/Z, 296194)
  • Medical Research Council (MR/R006237/1, MR/PO18823/1)
  • Lister Institute of Preventive Medicine
  • NIHR Newcastle Biomedical Research Centre
  • Medical Research Council UK, NIHR Oxford Biomedical Research Centre and NIHR Clinical Research Network
  • NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust
  • Chan Zuckerberg Initiative (2017-173808)
  • Cancer Research UK (C609/A27326)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Keywords
inflammatory skin diseases, atopic dermatitis, psoriasis, fetal skin development, single-cell transcriptomics, skin immunity, innate immune cells, clonal expansion, macrophages, vascular endothelial cells, skin homeostasis
MeSH terms
Animals, Atlases as Topic, Cell Movement, Dendritic Cells, Dermatitis, Atopic, Dermatologic Agents, Humans, Immunity, Innate, Methotrexate, Phagocytes, Psoriasis, Skin, T-Lymphocytes, Mice, Single-Cell Analysis, Transcriptome, Datasets as Topic

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