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Mass-resolved electronic circular dichroism ion spectroscopy
Open accessAbstract
DNA circular dichroism in gas phase: Circular dichroism spectroscopy is widely used to distinguish between nonidentical mirror-image molecules. The technique relies on differential absorption of left versus right circularly polarized light and therefore tends to require solution-phase samples for adequate sensitivity. Daly et al. now report gas-phase circular dichroism spectra of DNA oligonucleotides based on detection of photodetached electrons rather than transmitted light (see the Perspective by Barran). The salient spectral features matched those in solution. Pairing the technique with mass spectrometry enables prior mass selection of particular molecules for analysis. Science , this issue p. 1465 ; see also p. 1426
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Circular dichroism was recently combined with mass spectrometry for oligonucleotides.
“Circular dichroism was recently combined with MS for oligonucleotides.174”
From Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry (2020) · cites this paper as [174]
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Zhang, X., Ren, J., Gao, Q., Liu, J., Zhang, L., Li, S., Tang, Y., Ren, F., Jiao, X., & Huang, J. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108570
Li, Y., Tao, C., Pan, Z., Tang, X., Li, Y., Zhou, J., Liu, C., & Bai, Y. (2026) · ENGINEERING Transformative Materials · doi:10.2738/engtm.2026.0008
Han, B., Cui, H., Chen, W., Ma, Z., Liang, D., Wang, D., Zhang, J., Song, J., & Tang, S. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.180842
Metadata
- Authors
- Daly, S., Rosu, F., & Gabelica, V.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Gabelica, Valérie
- Venue
- Science
- Published
- 2020-06-26
- Volume
- 368
- Issue
- 6498
- Pages
- 1465-1468
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W3037720709
- Cited by
- 68
- References
- 40
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 7 · 2023: 6 · 2022: 15 · 2021: 16 · 2020: 7
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- HAL (submittedVersion, other-oa)
- arXiv (Cornell University)
- Funders
- FP7 Ideas: European Research Council (ERC-2013-CoG-616551-DNAFOLDIMS)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Molecular spectroscopy and chirality
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- electronic circular dichroism, guanine-rich DNA, DNA secondary structure, electron photodetachment, circularly polarized light, chiral molecules
- MeSH terms
- Circular Dichroism, DNA, Guanine, Nucleic Acid Conformation, Mass Spectrometry
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