Synthesis of proteins by automated flow chemistry

Hartrampf, N., Saebi, A., Poskus, M., Gates, Z. P., Callahan, A. J., Cowfer, A. E., Hanna, S., Antilla, S. +10 more·2020·Science
DOI 10.1126/science.abb2491

Cited by (367)

Items 301–367 of 367

  1. An Efficient and Cost-effective Purification Methodology for SaCas9 Nuclease
    Allen C. T. Teng, Marjan Tavassoli, Suja Shrestha, Kyle Lindsay, Evgueni A. Ivakine, Ronald D. Cohn, J. Paul Santerre, Anthony O. Gramolini · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  2. The chemical synthesis of knob domain antibody fragments
    Alex Macpherson, James R. Birtley, Robert J. Broadbridge, Kevin Brady, Yalan Tang, Callum Joyce, Kenneth C. Saunders, Gregory Bogle, John Horton, Sebastian Kelm et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  3. SYNFORM ISSUE 2021/07
    Matteo Zanda · 2021 · Synfacts
  4. Large-Eddy Simulations and Aeroacoustics
    Thomas Hüttl, Claus D. Wagner, Pierre Sagaut, J.M. Boersma, Marc C. Jacob, Jerome C. Boudet, Damiano Casalino, Marc Michard, Marc Terracol, Eric Manoha et al. · 2005 · elib (German Aerospace Center)
  5. 钢铁节能，大有可为——论重钢股份公司的节能潜力
    董荣华 · 2005
  6. Automated, Multistep Continuous‐Flow Synthesis of 2,6‐Dideoxy and 3‐Amino‐2,3,6‐trideoxy Monosaccharide Building Blocks
    Subbarao Yalamanchili, Tu-Anh V. Nguyen, Alexander Zsikla, Gavin Stamper, Ashley E. DeYong, John Florek, Olivea Vasquez, Nicola L. B. Pohl, Clay S. Bennett · 2021 · Angewandte Chemie
  7. De Novo Synthetic Design for Ultrafast Formation of Disulfide Bonds in Peptides and Proteins .pdf
    Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik · 2020 · ChemRxiv
  8. SYNFORM ISSUE 2021/07
    Matteo Zanda · 2021 · Synlett
  9. Synthesis of Multi-Module Low Density Lipoprotein Receptor Class A Domains with Acid Labile Cyanopyridiniumylides (CyPY) as Aspartic Acid Masking Groups
    Kevin Neumann, Alex Vujinovic, Saidu Kamara, Simon Baldauf, Jeffrey W. Bode · 2021 · ChemRxiv
  10. Stirring Peptide Synthesis to a New Level of Efficiency
    Johnny N Naoum, Israel Alshanski, Guy Mayer, Poriah Strauss, Mattan Hurevich · 2021 · ChemRxiv
  11. Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates
    Chengxi Li, Alexander J. Callahan, Kruttika-Suhas Phadke, Bryan H. Bellaire, Charlotte E. Farquhar, Genwei Zhang, Carly K. Schissel, Alexander J. Mijalis, Nina Hartrampf, Andrei Loas et al. · 2021 · ChemRxiv
  12. Toward the green synthesis of peptides and peptidic drugs
    Dóra Bogdán, Levente Kárpáti, István M. Mándity · 2022 · Elsevier eBooks
  13. Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex
    Christian Winter, Alexander Domnick, Darja Černova, Robert Tampé · 2022 · Angewandte Chemie
  14. Advances in peptide synthesis
    Zhipeng A. Wang, Ji‐Shen Zheng · 2022 · Elsevier eBooks
  15. Drug discovery: Standing on the shoulders of giants
    Susan M. Miller, Walter H. Moos, Barbara H. Munk, Stephen A. Munk, Charles P. Hart, David C. Spellmeyer · 2023 · Elsevier eBooks
  16. Backgrounder—Part 2
    Susan M. Miller, Walter H. Moos, Barbara H. Munk, Stephen A. Munk, Charles P. Hart, David C. Spellmeyer · 2023 · Elsevier eBooks
  17. eLife Assessment: Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    Gary Yellen · 2023 · eLife
  18. Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    Loïc Duffet, Elyse T. Williams, Andrea Gresch, Simin Chen, Musadiq Ahmad Bhat, Dietmar Benke, Nina Hartrampf, Tommaso Patriarchi · 2023 · eLife
  19. Joint Public Review: Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    2023 · eLife
  20. Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    Loïc Duffet, Elyse T. Williams, Andrea Gresch, Simin Chen, Musadiq Ahmad Bhat, Dietmar Benke, Nina Hartrampf, Tommaso Patriarchi · 2023 · eLife
  21. Author Response: Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    Loïc Duffet, Elyse T. Williams, Andrea Gresch, Simin Chen, Musadiq Ahmad Bhat, Dietmar Benke, Nina Hartrampf, Tommaso Patriarchi · 2023 · eLife
  22. eLife Assessment: Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    Gary Yellen · 2023 · eLife
  23. Public Review: Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution
    2023 · eLife
  24. Tiềm năng ứng dụng của các peptide kháng khuẩn trong việc kiểm soát nhiễm khuẩn vết thương
    2023 · Journal of Science and Technology - HaUI
  25. Catalytically Competent Fluorinated Barnase Variants
    Beate Koksch, Alexander Langhans, Michael Krummhaar, Christian Roth · 2023 · Synlett
  26. Probing PAC1 receptor activation across species with an engineered sensor
    2024
  27. One-pot ligation of multiple peptide segments via N-terminal thiazolidine deprotection chemistry
    Genki Nakamura, Koki Nakatsu, Gosuke Hayashi · 2024 · Methods in enzymology on CD-ROM/Methods in enzymology
  28. Water-Catalyzed Direct Amide Bond Formation between N-Sulfonyl-1,2,3-Triazoles with Carboxylic Acids Via Desulfonation
    Zhongjing Hu, Yaqi Deng, Jian Ji, Jinhua Liu, Yun Zhao, Shunying Liu, Shihua Luo · 2024 · SSRN Electronic Journal
  29. Chemische Proteinsynthese/Trendbericht Biochemie 2024 (1/3)
    Nina Hartrampf · 2024 · Nachrichten aus der Chemie
  30. Joint Public Review: Probing PAC1 receptor activation across species with an engineered sensor
    Reto B Cola, Salome N Niethammer, Preethi Rajamannar et al. · 2024 · eLife
  31. Author response: Probing PAC1 receptor activation across species with an engineered sensor
    Reto B. Cola, Salome Nora Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq Ahmad Bhat, Kevin Assoumou, Elyse T. Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke et al. · 2024 · eLife
  32. Probing PAC1 receptor activation across species with an engineered sensor
    Reto B. Cola, Salome Nora Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq Ahmad Bhat, Kevin Assoumou, Elyse T. Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke et al. · 2024 · eLife
  33. From De Novo to Xeno: Advancing Macromolecule Design beyond Proteins
    Tyler S. Stukenbroeker · 2024 · ACS Synthetic Biology
  34. In vivo Antibody Painting for Next Generation Weight Loss Drugs
    Katsushi Kitahara, Aurélie Rondon, Edward Miller, Howard H. Mak, Andrei Loas, Bradley L. Pentelute · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Equimolar Cross-Coupling Using Reactive Coiled Coils for Covalent Protein Assemblies
    Hironori Takeuchi, Elee Shimshoni, Satish Gandhesiri, Andrei Loas, Bradley L. Pentelute · 2024 · Bioconjugate Chemistry
  36. Chemical Tools for Decoding the Functions of O-GlcNAcylation
    Yi Hao, Dangliang Liu, Qi Wen Deng, Suwei Dong · 2024 · Springer eBooks
  37. Straightforward, scalable, solution-phase synthesis of peptide bonds in flow
    Zoe E. Wilson, Enol López, Nils J. Flodén, Charis Watkins, Giulia Bianchini, Steven V. Ley · 2025 · Journal of Flow Chemistry
  38. Chemical Protein Engineering: Backbone Cyclization Rescues Folding of a 183‐Residue Truncated Domain of Malaria Parasite Protein PfAMA1
    Jamsad Mannuthodikayil, Vishal Malik, Abhisek Kar, Sameer Singh, Kalyaneswar Mandal · 2025 · Chemistry - A European Journal
  39. Peptide Synthesis Nomenclature
    Christian F. W. Becker, Florine Cavelier, Yosuke Demizu, Xuechen Li, William D. Lubell, John D. Wade, Paolo Rovero · 2025 · Journal of Peptide Science
  40. Novel methods of catalytic activation in flow
    Aitor Maestro, Adrián López-Francés, Bhanwar K. Malviya · 2025 · Advances in catalysis
  41. Peptides on Tap: Automated Flow Synthesis With Standard HPLC
    Patrick Romanens, Sofía Barluenga, Millicent Dockerill, Guixian Zhao, Francesco Russo, Nicolas Winssinger · 2026 · Helvetica Chimica Acta
  42. Integration of Machine Learning and Automated Synthesis for Accelerated Drug and Material Research
    Wenguang Xiao, Houlin Su, Yawei Ma, Youfu Ma, Wencong Lu, Lisheng Wang, Ge Li, Mingqing Yuan, Lihe Jiang, Lixin Liang et al. · 2025 · ChemistrySelect
  43. On-surface polymerization of natural amino acids: substrate engineering and monomer design
    Yinuo Zhu, Miao Zhou, Tianchao Niu · 2025 · Nanoscale
  44. Residence Time Distribution in Flow Reactors for Solid Phase Synthesis
    Sebastián Pinzón-López, Wei-Hsin Hsu, Dominik Ebert, Mei Huei-Lin, Matthias Kraume, Peter H. Seeberger, José Danglad‐Flores · 2025 · SSRN Electronic Journal
  45. Surface-bioengineering of bacteriophage AP205 and MS2 virus-like particles with novel Spytag003 for antigen conjugation
    Hong Liu, Ebenezer Tumban · 2026 · Journal of Genetic Engineering and Biotechnology
  46. Methoden zur Synthese und Analyse von Peptiden und Proteinen
    Daniel Krois · 2026 · Springer eBooks
  47. Ene and Epoxide Impurities in Fluorenylmethoxycarbonyl (Fmoc) α-Substituted Amino Acids: Causes of Formation, Reactivity, and Means of Minimization
    Milad Mohammadi, Nicole Swist, Jon Holbech Rasmussen, Jan Pawlas · 2026 · Organic Process Research & Development
  48. Modulation of the human cathelicidin dimerization interface separates antimicrobial activity from mammalian membrane disruption
    John S. Albin, Dimuthu Ashcharya Vithanage, Wayne Vuong, Corey R. Johnson, Bradley L. Pentelute · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Click Immobilization of (Bio)Catalysts in Batch and Continuous Flow Chemistry Systems
    Ross D. Jansen‐van Vuuren, Luka Jedlovčnik, J. Cerkovnik · 2026 · Topics in heterocyclic chemistry
  50. Lassopeptide und Flowsynthese
    Nina Hartrampf · 2026 · Nachrichten aus der Chemie
  51. Total chemical synthesis of pentameric cholera toxin subunit B
    Paul Spaltenstein, Samuel R. Scherer, Tyler E. Jones, Riley J. Giesler, Michael S. Kay · 2026 · Chemical Communications
  52. Recombinant Expression and Automated Flow Synthesis of Fold-Switching Proteins Derived from Streptococcus Protein G
    Clara Kjerfve, Joanna Koryo Kwao, Jordan Wolfe, Jasmine Glover, Bryson Wood, Christian Golden, Nicholas L. Truex · 2026 · Biochemistry
  53. Towards filling the gap between organocatalysis and biocatalysis — catalysis by folded peptides and miniproteins
    Ewa Rudzińska‐Szostak, Łukasz Berlicki · 2026 · Tetrahedron Chem
  54. The Calculation “BWC+S&T+Verification” Does not Work Without the Variable “Convergence”
    Gunnar Jeremias, Anna Krin · 2026 · T.M.C. Asser Press eBooks
  55. Phosphorylation tunes electrostatically driven protein-RNA interactions
    Marie Synakewicz, Adhvitha Premanand, H Burgisser, Sarah Habeler, Lucia Rosanna Franchini, Noémie Kociolek, Mark F. Nüesch, Antoine Cléry, Daniel Nettels, Frédéric H.‐T. Allain et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Immobilized Activation Base for Solid-Phase Peptide Synthesis in Flow
    Anna Wettler, Bálint Tamás, Nina Hartrampf · 2026 · The Journal of Organic Chemistry
  57. Recent advances in chemoselective protein desulfurization: from VA-044 to emerging boron, photochemical, iron-catalyzed, and ultrasound methods
    Xiaoyang Ding, Chuntong Li, Xinyan Wang, Lu-Jun Liang · 2026 · Organic & Biomolecular Chemistry
  58. Precision chemical synthesis of PEGylated IGF2 for potent and selective lysosomal degradation of transmembrane proteins
    Boyuan Fan, Xiaoxiong Wei, Weijie Li, Siyi Cui, Xiaojun Wang, JiBin Cui, Xiaojun Wang, Wei Cong, Man Pan, Qingyun Zheng et al. · 2026 · Organic & Biomolecular Chemistry
  59. ChemGrasp: affordance-aware dexterous grasping for laboratory automation
    Xuanwei Liu, Tiewei Shang, Rui Wang, Junliang Li, Jisong Pan, Zixin Wang, Yongquan Chen · 2026 · Clean Energy
  60. A simplified model for solid phase synthesis flow reactors
    Sebastián Pinzón-López, Wei‐Hsin Hsu, Dominik Ebert, Matthias Kraume, Peter H. Seeberger, José Danglad‐Flores · 2026 · Reaction Chemistry & Engineering
  61. Experimental automation for high-throughput collection of phase behavior and dynamic light scattering data for thermally-responsive polymers
    Paul F. Salipante, Phillip D. Pickett, Austin Gallegos, Colin McCarragher, Steven D. Hudson, Vivek M. Prabhu · 2026 · Soft Matter
  62. Methods for the Synthesis and Analysis of Peptides and Proteins
    Daniel Krois · 2026 · Springer eBooks
  63. Sacrificial Methionine Residues Protect Active‐Site Histidines From Oxidation
    Evans C. Wralstad, Jessica Sayers, Giulio Fittolani, David Sarabia-Castillo, Alex J. Callahan, Bradley L. Pentelute, Ronald T. Raines · 2026 · Angewandte Chemie Novit
  64. Anticancer Peptides: Design Principles, Translational Bottlenecks, and Emerging Opportunities
    Marissa E. Di, Y. Peter Di · 2026 · Molecules
  65. Continuous microreactor technology to container-scale manufacturing: A blueprint for the next generation pharma industry
    Maxim Oshchepkov, Konstantin Kochetkov, Pavel Pavlov, Михаил Ильин, Alexander Oshchepkov · 2026 · The Innovation Insights
  66. Automated Solid‐Phase Flow Synthesis for Scaffold Diversification of a High‐Throughput Screening Hit
    Zhenyang Yu, Zhi‐Qi Zhang, Jiale Wu, Yanbin Zhang, Hwee Ting Ang, Feng Zhou, Jackie Ang, Mei Yee 黃美儀 Wong, Ronald Toh Kuan Hai, Frankie S. Mak et al. · 2026 · Angewandte Chemie International Edition
  67. Automated Solid‐Phase Flow Synthesis for Scaffold Diversification of a High‐Throughput Screening Hit
    Zhenyang Yu, Zhi‐Qi Zhang, Jiale Wu, Yanbin Zhang, Hwee Ting Ang, Feng Zhou, Jackie Ang, Mei Yee 黃美儀 Wong, Ronald Toh Kuan Hai, Frankie S. Mak et al. · 2026 · Angewandte Chemie