The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Sentinel p16 INK4a+ cells in the basement membrane form a reparative niche in the lung
Open accessAbstract
We engineered an ultrasensitive reporter of p16 INK4a , a biomarker of cellular senescence. Our reporter detected p16 INK4a -expressing fibroblasts with certain senescent characteristics that appeared shortly after birth in the basement membrane adjacent to epithelial stem cells in the lung. Furthermore, these p16 INK4a+ fibroblasts had enhanced capacity to sense tissue inflammation and respond through their increased secretory capacity to promote epithelial regeneration. In addition, p16 INK4a expression was required in fibroblasts to enhance epithelial regeneration. This study highlights a role for p16 INK4a+ fibroblasts as tissue-resident sentinels in the stem cell niche that monitor barrier integrity and rapidly respond to inflammation to promote tissue regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“It should be noted, however, that senescent cells also have important physiological roles and that their clearance may be detrimental in certain conditions3–5.”
From Spatial mapping of cellular senescence: emerging challenges and opportunities (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, there are beneficial effects of senescent cells in certain circumstances, which brings more critical requirements to study the right time and condition for senolytics to overcome the harmful effects.16”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [16]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Cellular senescence is not a mammalian-specific phenomenon but is widespread across the animal kingdom, including vertebrate and invertebrate organisms.”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [116]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Senescence in non-mammals impacts on many aspects of organismal physiology, from development116,122 to regeneration (e.g., salamander limbs117, zebrafish fins118, whole hydra polyps120) and ageing119,123,124.”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [116]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Markers of senescence have been detected in birds (e.g., quail114), amphibians (e.g., axolotls115, xenopus116, and newts117), fish (e.g., zebrafish118 and killifish119), and invertebrates (e.g., hydra120 and Drosophila121).”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [116]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Self-citationClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Cellular Senescence: Defining a Path Forward
Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225
Self-citationNaturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,876
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,584
NicheNet: Modeling intercellular communication by linking ligands to target genes
Browaeys, R., Saelens, W., & Saeys, Y. (2020) · Nature Methods · doi:10.1038/s41592-019-0667-5 · Cited by 2,192
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045
Self-citationClearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–182 of 182
Insights into the therapeutic strategies for aging and aging-associated diseases
Dong, R., Wu, Q., Kan, J., Fu, C., Sorrentino, V., Chow, A., Lei, Y., Wu, D., Xu, Z., Du, J., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02662-z · Cited by 12
Targeting metabolism to influence cellular senescence a promising anti-cancer therapeutic strategy
Wang, Z., Gao, J., & Xu, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116962 · Cited by 9
The skin of the naked mole-rat and its resilience against aging and cancer
Wlaschek, M., Singh, K., Maity, P., & Scharffetter‐Kochanek, K. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111887 · Cited by 7
Li, Q., Wu, T., Fan, Y., Cheng, J., Wang, J., Xu, B., Sun, M. J., Gong, X., Deng, H., Ao, Y., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.106015 · Cited by 7
“58 The evidence suggests that, to some extent, senolytic administration in the articular cavity cannot totally eliminate senescent cells, which have the potential to sense microenvironment alterations thus activating regenerative signals.”
Progress in anti-ageing drug research for age-related diseases: A review
Zhou, Z., Duan, H.-T., Xue, S.-T., & Li, Z. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102982 · Cited by 13
Airway injury induces alveolar epithelial responses mediated by macrophages
Wong, I. G., Paschini, M., Stark, J. R., Vazquez, A. B., Ya, V., Moye, A. L., Dang, S. M., Trovero, M. F., Thompson, E. L., Ahmed, S., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116881 · Cited by 7
Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway
Liu, L., Zhu, L., Liang, Q., Yu, L., Hu, L., Yu, Y., Cheng, X., & Bao, H. (2024) · Inflammation Research · doi:10.1007/s00011-024-01883-8 · Cited by 8
Hasanaj, E., Beaulieu, D., Wang, C., Hu, Q., Bueno, M., Sembrat, J., Pineda, R., Melo-Narváez, M. C., Cárdenes, N., Yanwu, Z., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.21.629928 · Cited by 7
Self-citationRegenerative therapeutics for chronic obstructive pulmonary disease
van der Koog, L., Showell, H., Nugraha, D. F., Lehmann, M., Conlon, T. M., Yildirim, A. Ö., Fuentes‐Mateos, R., Baarsma, H. A., Ng-Blichfeldt, J.-P., Melgert, B. N., et al. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100124 · Cited by 8
Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease
Kliment, C. R., Gurkar, A. U., Cárdenes, N., Ramonell, R. P., Finkel, T., & Königshoff, M. (2026) · Physiological Reviews · doi:10.1152/physrev.00024.2025 · Cited by 6
Allen, N. C., Ringler, C., Woo, S., Phipps, S., Lee, J. Y., Reyes, N. S., Biswas, R., Neyton, L. P. A., Willmore, A., Caryotakis, S. E., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.016 · Cited by 8
Self-citationControversies and Recent Advances in Senescence and Aging
Wagner, N., & Wagner, K. (2023) · Cells · doi:10.3390/cells12060902 · Cited by 6
Santiago, F. E., Adige, T., Mahmud, S., Dong, X., Niedernhofer, L. J., & Robbins, P. D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321182121 · Cited by 5
Zheng, H., Wang, X., Gao, Z., Zhang, X., Liu, J., Yan, J., Li, N., Chen, R., Xu, Y., Yang, Y., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123706 · Cited by 5
A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing
Zheng, Z., Wei, X., Jiang, Z., Xie, D., Shi, P., Ma, J., Yu, Q., He, Y., Pang, A., Zeng, J., et al. (2025) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-025-01509-5 · Cited by 6
Self-citationZhao, L., Xu, Z., Zhao, P., Pang, Z., You, Y., Wu, C., Zhu, D., Su, M., Zhang, N., Luo, J., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02886-y · Cited by 5
Cadar, A. N., Torrance, B. L., Fischler, S. A., Djaba, D. A., Haddad, Z. L., Teskey, D. E., Nagaraju, M., Gorgei, K. A., Lorenzo, E. C., Haynes, L., et al. (2025) · Aging Cell · doi:10.1111/acel.70345 · Cited by 5
“It is possible that D + Q treat-ment may interfere with the key role of senescence during lung repair (Reyes et al. 2022).”
Nakano, Y., & Johmura, Y. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvae098 · Cited by 7
Self-citationCellular senescence as a source of chronic microinflammation that promotes the aging process
Nakanishi, M. (2025) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.101.014 · Cited by 5
Self-citationMechanisms and markers of lung ageing in health and disease
Miller, Z., Twardowski, L.-M., Reader, B. F., Rojas, M. M., Lehmann, M., & Mora, A. L. (2025) · European Respiratory Review · doi:10.1183/16000617.0233-2024 · Cited by 10
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Lim, J., Sirisereephap, K., Wang, H., Trimaglio, G., Chung, K., Korostoff, J. M., Kajikawa, T., Li, X., Surboyo, M. D. C., Maekawa, T., et al. (2026) · Advanced Science · doi:10.1002/advs.202509263 · Cited by 5
Senescent fibroblasts support lung repair
Strzyz, P. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00559-7 · Cited by 4
Khosla, S. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180558 · Cited by 4
Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticityPreprint
Lee, J. Y., Reyes, N. S., Woo, S., Goel, S., Stratton, F., Kuang, C., Mansfield, A. S., LaFave, L. M., & Peng, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.29.605645 · Cited by 4
Self-citation(孙义), Y. S., Lin, Y., Xing, S., Huang, W., Wang, Y., Guo, G., Yan, H., Zhao, D., Cheng, W., Wu, Z., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106146 · Cited by 3
Recycling senescent cell lipids for targeted senotherapy
Ji, X., He, X., Cai, H., Tang, P., Zhou, H., Wang, J., Wu, Y., Zhou, J., Lin, Z., Xu, K., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70486-0 · Cited by 3
Senescent cell heterogeneity: origins, detection, and therapeutic implications
Wu, R., Zhu, J., Kim, H., & Xu, M. (2026) · Trends in Cell Biology · doi:10.1016/j.tcb.2026.03.015 · Cited by 5
Immunological consequences of senescence in physiology and pathology
Zubova, A., Pietrocola, F., & Morsli, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08335-3 · Cited by 6
Exline, J. E., Volyanyuk, M., Lotesto, K. M., Segismundo, A. B., Byram, S. C., & Foecking, E. M. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149611 · Cited by 4
Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis
Polkoff, K. M., Lampe, R., Gupta, N. K., Murphy, Y., Chung, J., Carter, A., Simon, J. M., Gleason, K. L., Moatti, A., Murthy, P. K. L., et al. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2024-0040oc · Cited by 3
He, X., Liu, F., Xu, P., & Gong, Q. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311696 · Cited by 2
Advancing Alzheimer's disease treatment: A literature review on senolytic intervention
Onuh, V. C. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251376540 · Cited by 2
Liu, J., Liu, X., Fu, H., Yu, C., Jing Hua, H. U., Fu, J., & Yin, J. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01922 · Cited by 2
Kawamoto, S., Horiguchi, H., Torigoe, D., Wakita, M., Ito, K., Sugawara, S., Zhou, X., Mikawa, T., Park, J. H., Jung, B. K., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00740-5 · Cited by 2
“…bene fi cially to speci fi c physiological processes, such as promoting wound healing, maintaining blood-tissue barriers, and activating immune responses, depending on the biological context (Grosse et al, 2020; Kang et al, 2011; Krizhanovsky et al, 2008; Reyes et al, 2022; Zhao et al, 2024).”
SenSet defines cell-type specific senescence signatures in the aged human lung
Hasanaj, E., Beaulieu, D., Wang, C., Hu, Q., Rosas, L., Bueno, M., Sembrat, J., Pineda, R., Melo-Narváez, M. C., Cárdenes, N., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00762-8 · Cited by 11
“Similarly, a recent work also demonstrated that fi broblasts are the main cell type undergoing senescence changes under homeostatic conditions and contribute to epithelial regeneration in a novel mouse model tracking p16 INK4a + cells (Reyes et al, 2022).”
Self-citationEtoh, K., Hino, Y., Morishita, H., & Nakao, M. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.03.020 · Cited by 2
Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions
Deng, J., Sun, R., Bai, Z., Fang, L., Zhao, X., & Yang, D. (2026) · Aging · doi:10.18632/aging.206375 · Cited by 2
Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency
Sin, J. H., Bowman, C. J., Germino, J., Phillips, S. H., Sucharov, J., Liu, X., Wang, Y., Miller, C. N., Parent, A. V., Bodansky, A., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02536-0 · Cited by 2
Molecular mechanisms and recent advances in cellular senescence
Hussain, A., Tatar, M., & Gong, R. (2026) · Cell & Bioscience · doi:10.1186/s13578-026-01596-x · Cited by 2
Senotypes define the diverse landscape of senescent cells
Schafer, M. J., Basisty, N., Hertzel, A. V., Rindone, A. N., Elisseeff, J. H., Suryadevara, V., Aliferis, C., Robbins, P. D., Niedernhofer, L. J., Miller, K. N., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01148-5 · Cited by 2
ELAVL4 encoded RNA binding protein HuD controls skin cellular senescence through CDKN1A
Chen, J., Qi, D., Gao, Y., Sun, W., Li, Y., Ding, C., & Ma, X. (2023) · Gene Reports · doi:10.1016/j.genrep.2023.101823 · Cited by 2
Luo, L., Yang, H., Huang, J., Chen, D., He, Y., Lin, J., Zeng, H., Hua, C., Lin, Z., Wu, M., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04268-8 · Cited by 3
Senescent cells exhibit features of developmental signaling centresPreprint
Gonçalves, D. S., Dulac, L., Ritschka, B., Rhinn, M., Klein, A., Wyatt, C. D. R., Irimia, M., & Keyes, W. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.30.685565 · Cited by 2
Muthumalage, T., & Rahman, I. (2025) · Inhalation Toxicology · doi:10.1080/08958378.2025.2577236 · Cited by 1
“…pathways related to downstream immune and tissue remodeling, resulting in an inability to effectively regulate inflammation and initiate proper tissue repair, leading to ongoing tissue damage and the development of emphysema-like changes (Cottage et al., 2019; Lv et al., 2020; Reyes et al., 2022).”
Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes
Luo, Y., Zhu, X., Le, Q.-R., Chen, W., Xu, Y., Chen, X., Yuan, H., Yang, X., Xu, J., Zhong, J., et al. (2025) · BMC Biology · doi:10.1186/s12915-025-02472-9 · Cited by 1
External immune sentinels in the seawater ecosystem: the specialization of bivalve hemocytes
Rey-Campos, M., Saco, A., Panebianco, A., Castro, J., Romero, A., Novoa, B., & Figueras, A. J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1765948 · Cited by 1
“The most studied vertebrate sentinel cells include macrophages and dendritic cells (2, 3), although fi broblasts (4, 5), neural stem cells (6), intestinal tuft cells (7), and skin-resident immune cells such as Langerhans cells and keratinocytes (8) also show sentinel functions.”
Fan, Y., Wang, Z.-H., Zhang, X., Dong, Y., Liu, X., Luo, G., Yang, H., Li, H., Wang, Z., Tang, Q., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04138-2 · Cited by 1
Johmura, Y., Wang, T.-W., & Nakanishi, M. (2026) · EMBO Reports · doi:10.1038/s44319-026-00752-1 · Cited by 1
Self-citationZhang, W., Liang, Y., Sun, Y., Wang, J., Huang, W., Xing, S., Zhang, Z., Lin, Y., Zeng, L., Lei, Q., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106315 · Cited by 1
“79,82 AS-p21 could efficiently down-regulate the expression levels of p21 by targeting and degrading p21 mRNA.”
Li, Z., Chi, H., Zhu, H., Huang, P., Huang, L., & Lin, W. (2026) · Science China Chemistry · doi:10.1007/s11426-025-3334-8 · Cited by 1
Targeting the senescence‒autophagy axis via p16INK4a inhibition alleviates pulmonary fibrosis
Yoo, Y. J., Zhang, M., Jin, S.-H., Lee, Y. R., Jin, H., Doan, T.-P., Kim, S., Choi, S., Park, E., Na, S., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02730-4 · Cited by 1
Xu, S., Guo, J., Kang, Y., Wang, Q., Ming, Y., Chen, W., Wang, M., Huang, Z., Huang, Y. Q., & Jia, B. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03086-6 · Cited by 1
Regenerative Medicine and the Hope for a Cure
Lehmann, M., & Königshoff, M. (2021) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2021.03.012 · Cited by 1
Bozier, J., Wang, B., de Vries, M., Brandsma, C., van den Berge, M., Timens, W., Heijink, I. H., Oliver, B. G. G., & Woldhuis, R. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555286 · Cited by 1
Luo, Y., Zhu, X., Le, Q.-R., Chen, W., Xu, Y., Chen, X., Yang, X., Yuan, H., Xu, J., Zhong, J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5848058/v1 · Cited by 1
Watts, T., Johnston, H. E., Al-Mufti, Y., Odle, R., Hodgson, R. E., Okkenhaug, H., Carr, H. L., Cranwell, S., Wu, E., Walker, S. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.07.674107 · Cited by 1
Developmental senescence profiling reveals Eda2r as a common mediator in the core senescence programPreprint
Klein, A., Gonçalves, D. S., Dulac, L., Knauer-Meyer, T., Durik, M., Chan, A. S. L., Birling, M., Rhinn, M., Narita, M., & Keyes, W. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.30.685553 · Cited by 1
He, X., Liu, F., Xu, P., & Gong, Q. (2023) · Preprints.org · doi:10.20944/preprints202312.1454.v1
Cellular senescence is required for cardiac regeneration
(2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00494-0
Identifying key targets and immune environment in wound healing based on iron overload-related genes
Peng, Y., Sheng, J., Liu, T., He, R., & Xu, P. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-025-04140-y
Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skinPreprint
Wang, D., Wang, Z., Yang, Y., Bai, F., Li, H., He, J., Zhou, F., Chen, T., Fang, T., Wu, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.17.648896
C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging
Pelletier, L., Ayissi, K. N., Gorwood, J., Capel, É., Morichon, R., Mantecon, M., Auclair, M., Alili, R., Katlama, C., Cuzin, L., et al. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02815-4
Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes
Kawatani, K., Aikawa, T., Tabrizi, Z., Pan, Y., Ren, Y., Wang, N., Kurti, A., Nambara, T., Ikezu, C. C., Shue, F., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02085-x
Fibroblast orchestration of inflammaging via NF-kB activationPreprint
Allen, N. C., Ringler, C., Lee, J. Y., Reyes, N. S., Biswas, R., Caryotakis, S. E., Magnen, M., Ruivo, P., Auyeung, V. C., Looney, M. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.01.679697
Self-citationApplication of senescence reporter mouse models in panvascular diseases
Li, H., Zhang, Y., Tian, Z., & Zhang, S. (2025) · Vessel Plus · doi:10.20517/2574-1209.2025.99
Ijima, S., Saito, Y., Yamamoto, S., Nagaoka, K., Iwamoto, T., Kita, A., Miyajima, M., Sato, T., Miyazaki, A., & Chikenji, T. (2024) · Figshare · doi:10.6084/m9.figshare.26649603
Anderson, S. R., Chiaranunt, P., Mroz, N. M., Wade, S. D., Pitchai, F. N. N., Okamura, S., McDonough, A., Chen, Y., Molofsky, A. B., Weinstein, J. R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.08.698513
Self-citationMonitoring senescent cell dynamics in wound healing using a p16-tdtomato mouse model
Wang, Q., Shvedova, M., Abdelkader, M., & Roh, D. S. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.12.029
Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotypePreprint
Chua, Z. M., Tanaka, H., Abele, A., Rajesh, A., Teneche, M. G., Lei, X., Miller, K. N., Davis, A., Macip, C. C., Haddadin, L., et al. (2026) · Research Square · doi:10.64898/2026.02.16.706244
Molecular evolution of animal aging
Nussey, D. H., di Fagagna, F. D., Bardin, A. J., Blau, H. M., Brunet, A., Bulavin, D. V., Guo, L., Hara, E., Junker, J. P., Gorbunova, V. A., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00725-z · Cited by 1
“However, the issue remains complex, as certain types of senescent cells perform important bene-fi cial functions (Born et al, 2023; de Magalhaes, 2024; Grosse et al, 2020; Reyes et al, 2022) — for instance, as part of a defense mechanism known as disease tolerance (Triana-Martinez et al, 2024).”
Forgotten foundations: basement membranes in lung function and cancer
Yoo, D., Cox, T. R., & Parker, A. L. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00599.2025
Sun, Y., Zou, H., Cui, A., Dong, H., Abulizi, P., Zhao, P., Wang, J., Leung, W. K., & Wang, Q. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116647
Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool
Buch, M. L., Esser, H., Perera, H., Zheng, R., Ferreira-González, S., & Forbes, S. J. (2026) · Transplant International · doi:10.3389/ti.2026.16347
“Similarly, senescence functions as a tumor suppressor mechanism and prolonged SnC ablation may impair immune surveillance [113, 117, 118].”
Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosisPreprint
Rindone, A. N., Nagaraj, S., Cho, A., Browne, M., Krishnan, K., Adkins, R. S., Lesperance, D., Orvis, J., Daswani, P. S., Mejías, J. C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.08.730636
JMJD3-driven epigenetic reprogramming of p16INK4a-positive cells promotes tendon regeneration
Liu, X.-N., Lu, W.-H., Wang, Y.-C., Zhang, P.-L., Su, Z.-Y., Cao, T., Zhang, Y.-F., Zhao, J.-J., Wang, J., Xiang, H.-L., et al. (2026) · Bone Research · doi:10.1038/s41413-026-00537-1
Li, G., Zhao, Z., Zhao, F., Ishikawa, M., Kumamoto, K., Ohmichi, K., Ishikawa, R., Yamazaki, S., Sun, Z., & Kurahara, L. H. (2026) · Engineering · doi:10.1016/j.eng.2026.07.037
Etrouth, S., Zhu, Y., & Zhang, D. (2026) · Journal of Respiration · doi:10.3390/jor6030021
“On the other hand, senescence may also exert beneficial effects during acute tissue injury. p16-expressing fibroblasts served as an inflammation-responsive reparative niche and promoted lung epithelial regeneration [296].”
Multidimensional Regulatory Network of Cellular Senescence: From Mechanisms to Theranostics
Lv, Z., Liu, Y., Liu, Y., Tan, Y., Man, Y., Shuqing, D., Zhang, Z., Lee, L. P., Chen, Q., & Liu, Z. (2026) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6c00849
The therapeutic potential of transposable element activity modulation
Morelli, G., D’Onghia, M., Mangiavacchi, A., & Orlando, V. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00528-z
“…event but is spatially and cellularly compartmentalized: specialized tissue-resident “ sentinel ” cells are poised to sense local damage signals and rapidly initiate a localized, calibrated in fl ammatory response (Antonelli and Kushner, 2017; Peiseler and Kubes, 2018; Reyes et al, 2022).”
Alveolar stem cells transdifferentiate to drive bronchiolar regeneration
Liu, K., Liu, Z., Meng, X., Tang, M., Di, F., Wang, Z., Li, C., Yang, S., Zhang, Y., Yang, X., et al. (2026) · Nature · doi:10.1038/s41586-026-11127-w · Cited by 1
Small extracellular vesicles as mediators of paracrine senescence in cellular models of aging
Llabrés-Mas, A. M., Merino-Navarro, A., Menendez-Garcia, M., & O’Loghlen, A. (2026) · Aging · doi:10.18632/aging.206425
Metadata
- Authors
- Reyes, N. S., Krasilnikov, M., Allen, N. C., Lee, J. Y., Hyams, B., Zhou, M., Ravishankar, S., Cassandras, M., Wang, C., Khan, I., Matatia, P., Johmura, Y., Molofsky, A., Matthay, M., Nakanishi, M., Sheppard, D., Campisi, J., & Peng, T.
- Affiliations
- University of California, San Francisco (US)
- The University of Tokyo (JP)
- Buck Institute for Research on Aging (US)
- Corresponding author
- Peng, Tien
- ORCID
- Venue
- Science
- Published
- 2022-10-14
- Volume
- 378
- Issue
- 6616
- Pages
- 192-201
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC10621323
- OpenAlex
- W4305040316
- Cited by
- 181
- References
- 38
- Citations by year
- 2026: 45 · 2025: 40 · 2024: 54 · 2023: 34 · 2022: 4
- FWCI
- 20.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Tobacco-Related Disease Research Program
- National Institutes of Health (DK063720)
- Japan Society for the Promotion of Science (20H00514, 19H03431)
- National Institute on Aging (DP2AG056034)
- National Heart, Lung, and Blood Institute (R01HL155622, R01HL142552, R01HL160895)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063720)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- p16INK4a, cellular senescence, epithelial stem cells, stem cell niche, tissue regeneration, secretory capacity, reporter system
- MeSH terms
- Basement Membrane, Epithelial Cells, Fibroblasts, Humans, Inflammation, Lung, Regeneration, Biomarkers, Cellular Senescence, Genes, Reporter, Cyclin-Dependent Kinase Inhibitor p16, Stem Cell Niche
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
