Sheppard, Dean

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell

TGF-β signaling in diseasesCell Adhesion Molecules Research

Cited by 2,076

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

Kim, K. K., Kugler, M. C., Wolters, P. J., Robillard, L., Galvez, M. G., Brumwell, A. N., Sheppard, D., & Chapman, H. A. (2006) · Proceedings of the National Academy of Sciences

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTGF-β signaling in diseases

Cited by 1,257

TGF-β signaling in health and disease

Massagué, J., & Sheppard, D. (2023) · Cell

TGF-β signaling in diseasesLiver physiology and pathology

Cited by 890

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 866

TGF-β Activation and Function in Immunity

Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology

TGF-β signaling in diseasesT-cell and B-cell Immunology

Cited by 856

TGF-β1 Signaling and Tissue Fibrosis

Kim, K. K., Sheppard, D., & Chapman, H. A. (2018) · Cold Spring Harbor Perspectives in Biology

TGF-β signaling in diseasesLiver physiology and pathology

Cited by 800

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

Tsukui, T., Sun, K.-H., Wetter, J. B., Wilson-Kanamori, J. R., Hazelwood, L. A., Henderson, N. C., Adams, T. S., Schupp, J. C., Poli, S. D., Rosas, I. O., et al. (2020) · Nature Communications

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSingle-cell and spatial transcriptomics

Cited by 765

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Mu, D., Cambier, S., Fjellbirkeland, L., Baron, J. L., Munger, J. S., Kawakatsu, H., Sheppard, D., Broaddus, V. C., & Nishimura, S. L. (2002) · The Journal of Cell Biology

TGF-β signaling in diseasesCell Adhesion Molecules Research

Cited by 729

Therapy for Fibrotic Diseases: Nearing the Starting Line

Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisLiver physiology and pathology

Cited by 655

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., et al. (2007) · Nature

T-cell and B-cell ImmunologyInflammatory Bowel Disease

Cited by 503

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 420

Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix

Munger, J. S., & Sheppard, D. (2011) · Cold Spring Harbor Perspectives in Biology

TGF-β signaling in diseasesCell Adhesion Molecules Research

Cited by 372

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

Bazigou, E., Xie, S., Chen, C., Weston, A., Miura, N., Sorokin, L., Adams, R., Muro, A. F., Sheppard, D., & Makinen, T. (2009) · Developmental Cell

Lymphatic System and DiseasesCell Adhesion Molecules Research

Cited by 347

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking αvβ5 integrin

Nandrot, E. F., Kim, Y., Brodie, S. E., Huang, X., Sheppard, D., & Finnemann, S. C. (2004) · The Journal of Experimental Medicine

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 319

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D. (2015) · Science Translational Medicine

Cell Adhesion Molecules ResearchTGF-β signaling in diseases

Cited by 311

An essential role for fibronectin extra type III domain A in pulmonary fibrosis

Muro, A. F., Moretti, F. A., Moore, B. B., Yan, M., Atrasz, R. G., Wilke, C. A., Flaherty, K. R., Martinez, F. J., Tsui, J. L., Sheppard, D., et al. (2008) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 297

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

Araya, J., Cambier, S., Markovics, J. A., Wolters, P., Jablons, D., Hill, A., Finkbeiner, W., Jones, K., Broaddus, V. C., Sheppard, D., et al. (2007) · Journal of Clinical Investigation

Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases

Cited by 257

Essential role for MFG-E8 as ligand for αvβ5 integrin in diurnal retinal phagocytosis

Nandrot, E. F., Anand, M., Almeida, D., Atabai, K., Sheppard, D., & Finnemann, S. C. (2007) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 241

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 202

αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

Hahm, K., Lukashev, M. E., Luo, Y., Yang, W. J., Dolinski, B. M., Weinreb, P. H., Simon, K. J., Chun Wang, L., Leone, D. R., Lobb, R. R., et al. (2007) · The American Journal of Pathology

Renal Diseases and GlomerulopathiesCell Adhesion Molecules Research

Cited by 190

Sentinel p16 INK4a+ cells in the basement membrane form a reparative niche in the lung

Reyes, N. S., Krasilnikov, M., Allen, N. C., Lee, J. Y., Hyams, B., Zhou, M., Ravishankar, S., Cassandras, M., Wang, C., Khan, I., et al. (2022) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 181

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Dodagatta-Marri, E., Meyer, D. S., Reeves, M. Q., Paniagua, R., To, M. D., Binnewies, M., Broz, M. L., Mori, H., Wu, D., Adoumie, M., et al. (2019) · Journal for ImmunoTherapy of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 177

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., et al. (2020) · Science Translational Medicine

Liver physiology and pathologySphingolipid Metabolism and Signaling

Cited by 122

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

Peng, Z., Ikenaga, N., Liu, S. B., Sverdlov, D. Y., Vaid, K. A., Dixit, R., Weinreb, P. H., Violette, S., Sheppard, D., Schuppan, D., et al. (2016) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 118