Cited by 289Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsMemory and Neural Mechanisms

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Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

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Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., Llorens-Martín, M.·2021·Science

DOI 10.1126/science.abl5163PMC PMC7613437

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Abstract

Disease and hippocampal dysfunction: Impaired function of the brain’s hippocampus can underpin psychiatric symptoms and cognitive impairment. Looking at postmortem brain samples from patients affected by any of several neurodegenerative disorders, Terreros-Roncal et al . investigated whether adult neurogenesis was disrupted (see the Perspective by Gage). Indeed, functions of the neurogenic niche shifted and the cells produced were abnormal in shape and differentiation. The neuronal plasticity characteristic of the hippocampus may make it especially susceptible to the ravages of neurodegenerative disease. —PJH

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Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357
Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622
Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease
Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577
Self-citation
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 974
Hippocampal neurogenesis in adult Old World primates
Gould, E., Reeves, A. J., Fallah, M., Tanapat, P., Gross, C. G., & Fuchs, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5263 · Cited by 815

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Comment on “Impact of neurodegenerative diseases on human adult hippocampal neurogenesis”
Álvarez-Buylla, A., Cebrián‐Silla, A., Sorrells, S. F., Nascimento, M. A., Paredes, M. F., García‐Verdugo, J. M., Yang, Z., & Huang, E. J. (2022) · Science · doi:10.1126/science.abn8861 · Cited by 15
Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"
Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M., Márquez-Valadez, B., Cafini, F., Rábano, A., & Llorens-Martín, M. (2022) · Science · doi:10.1126/science.abn7270 · Cited by 5
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Authors: Terreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., & Llorens-Martín, M.
Affiliations: Department of Molecular Neuropathology, Centro de Biología Molecular “Severo Ochoa” (CBMSO), Spanish Research Council (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Consejo Superior de Investigaciones Científicas (ES)
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Universidad Europea de Madrid (ES)
Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
ORCID: Terreros-Roncal, J.
Moreno-Jiménez, E. P.
Flor-García, M.
Rodríguez-Moreno, C. B.
Trinchero, M. F.
Cafini, F.
Rábano, A.
Llorens-Martín, M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2021-11-26
Volume: 374
Issue: 6571
Pages: 1106-1113
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.abl5163
PMC: PMC7613437
OpenAlex: W3205950297
Cited by: 289
References: 34
Citations by year: 2026: 35 · 2025: 59 · 2024: 66 · 2023: 78 · 2022: 48 · 2021: 3
FWCI: 17.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion, other-oa)
Conicet (submittedVersion, cc-by-nc-sa)
Funders: Alzheimer's Association (AARG-17-528125-RAPID, AARG-17-528125, 2015-NIRG-340709)
Association for Frontotemporal Degeneration
Fundación Ramón Areces
Centro de Biología Molecular Severo Ochoa
Ministerio de Economía y Competitividad (PRE2018-085233, PEJ2018-001725-A, PID2020-113007RB-I00, SAF-2017-82185-R, RYC-2015-171899)
Universidad Autónoma de Madrid (FPI-UAM-2017)
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
National Institute of Neurological Disorders and Stroke (P01NS083513, R01NS028478)
H2020 European Research Council (101001916)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: adult hippocampal neurogenesis, neurodegenerative diseases, dentate gyrus granule cells, neural stem cells, quiescence, neurogenic niche, microglial phagocytosis, astrocyte activation, aging, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, postmortem brain
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Amyotrophic Lateral Sclerosis, Female, Hippocampus, Humans, Huntington Disease, Male, Middle Aged, Parkinson Disease, Phagocytosis, Microglia, Dentate Gyrus, Neurodegenerative Diseases, Lewy Body Disease, Cell Proliferation, Neurogenesis, Frontotemporal Dementia, Neural Stem Cells

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