Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

Neurogenesis in the adult human hippocampus

Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172

Staging of alzheimer's disease-related neurofibrillary changes

Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567

Astrocytes give rise to new neurons in the adult mammalian hippocampus

Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495

Human Hippocampal Neurogenesis Persists throughout Aging

Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345

Dopamine depletion impairs precursor cell proliferation in Parkinson disease

Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 974

Hippocampal neurogenesis in adult Old World primates

Gould, E., Reeves, A. J., Fallah, M., Tanapat, P., Gross, C. G., & Fuchs, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5263 · Cited by 815

Adult Hippocampal Neurogenesis as a Therapeutic Target in Fetal Alcohol Spectrum Disorder

Cunningham, L. A., Tunc‐Ozcan, E., & Rodriguez, A. M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_5 · Cited by 2

The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis

Han, D., & Zhao, S. (2025) · Brain and Behavior · doi:10.1002/brb3.70560 · Cited by 2

Expression of two histone H4 epigenetic modifications (lysine 12 acetylation and lysine 20 trimethylation), and the senescence marker lamin B1 in the postnatal, adult, and old mouse brain

Sbriz, M., Shamshiddinova, M., Lossi, L., & Merighi, A. (2025) · Frontiers in Cell Death · doi:10.3389/fceld.2025.1632653 · Cited by 2

Ziziphi Spinosae Semen jujubosides extract ameliorates cognitive impairment by modulating brain BDNF/TrkB pathways and intestinal barrier integrity in HFD-fed mice

Jia, S., Tu, T., Hong, Y., Li, F., Wang, X., Meng, Y., & Lu, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107865 · Cited by 2

Delayed, transient, lateralized deficits in pattern separation and pattern completion after focal hippocampal irradiation in humans

Андреевна, К. О., Галкин, М. В., Danilov, G., Enikolopova, E. V., Kaverina, M. Y., Kuleva, A. Y., Fil'chenkova, N. A., Amelchenko, E. M., Anokhin, K. V., Lazutkin, A. A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-29852-z · Cited by 3

Gastrodin and gastrodigenin: advancing neurogenesis in neurological disease management

Ma, W., Wang, S., Yang, X., Chen, Y.-B., Li, Y., & Cui, Y. L. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118882 · Cited by 2

Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis

Nishanth, M. J., & Jha, S. (2023) · Discover Mental Health · doi:10.1007/s44192-023-00034-5 · Cited by 2

Predicting amyloid-PET status in a memory clinic: The role of the novel antero-posterior index and visual rating scales

Zilioli, A., Misirocchi, F., Pancaldi, B., Mutti, C., Ganazzoli, C., Morelli, N., Pellegrini, F. F., Messa, G., Scarlattei, M., Mohanty, R., et al. (2023) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2023.122806 · Cited by 2

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states

Yao, J., Dai, S., Zhu, R., Tan, J., Zhao, Q., Yin, Y., Sun, J., Du, X., Ge, L., Xu, J., et al. (2024) · eLife · doi:10.7554/elife.89507.4 · Cited by 2

Mapping the current trends and hotspots of adult hippocampal neurogenesis from 2004–2023: a bibliometric analysis

Liu, Y., Zhang, J., Gu, X., & Jia, S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1416738 · Cited by 2

Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblastosis as a Possible Pathocellular Mechanism of Hallucination

Irakkam, M. P. B. D., Joseph, J. H. M., & Kandasamy, M. (2024) · Neurosignals · doi:10.33594/000000712 · Cited by 2

Neurogenesis

Azadian, M. M., & George, P. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00040-1 · Cited by 3

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorderPreprint

Larrieu, T., Carron, C., Grieco, F., Weber, C., Ginggen, K., Delacrétaz, A., Gallart‐Ayala, H., Tsuda, M. C., Cameron, H. A., Eap, C. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.18.608479 · Cited by 2

Intervention Role of APOE in CNS Diseases: APOE Actions and APOE Neurogenesis Capability

Li, W., Ma, S., & Li, M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05028-8 · Cited by 1

Therapeutic role of mesenchymal stem cells in neurogenesis for management of neurological disorders: a scientometric study to an in-depth review

Wang, Q., Jiang, W., Feng, Y., Li, L., Chu, L., & Fang, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1588535 · Cited by 1

Amyotrophic lateral sclerosis and neurodegenerative diseases: A Mendelian randomization study

Lei, C., Chen, J., Chen, Z., Xiao, Y., Chen, J., Ma, C., Yang, M., Wu, D., & Xie, L. (2025) · Medicine · doi:10.1097/md.0000000000042847 · Cited by 1

Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection

Morizet, D., & Bally‐Cuif, L. (2025) · BioEssays · doi:10.1002/bies.70041 · Cited by 3

Probiotic supplementation attenuated early-life chemotherapy-induced brain development impairment in mice

Tan, A., Chen, J., Zhang, J., Tong, J., & Jiang, Z. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1697727 · Cited by 1

Adult neurogenesis dysfunction in Parkinson’s disease: Molecular pathology and functional implications

He, X., Huang, T., Yang, A., Li, Y., Bai, L., Chen, Y., Bai, J., & Zhang, X. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156340 · Cited by 1

Protocol to study adult neurogenesis in fresh-frozen human hippocampal tissue using an immunofluorescence quantitative approach

Gallardo‐Caballero, M., Márquez‐Valadez, B., & Llorens-Martı́n, M. (2026) · STAR Protocols · doi:10.1016/j.xpro.2025.104344 · Cited by 2

Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety

Larrieu, T., Grieco, F., Carron, C., Vilademunt, M., Weber, C., Ginggen, K., Delacrétaz, A., Gallart‐Ayala, H., Tsuda, M. C., Cameron, H. A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69240-3 · Cited by 3

Deciphering the microenvironment of adult neurogenesis: a perspective from neurodegenerative diseases

Lao, Z.-K., & Xu, N. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00546-4 · Cited by 1

An edge-aware salient context fusion and refinement network for hippocampal segmentation in MR images and its diagnostic value for mild cognitive impairment

Liu, L., Chen, X. J., Zeng, Q., Zhou, S., & Zhang, X. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1899123 · Cited by 1

Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease

Zhou, X., Han, J., Cui, X., Wu, S., Lu, Z., & Zong, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08940-2 · Cited by 1

Neurogenesis altered in multiple neurodegenerative diseases

Fyfe, I. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00588-4 · Cited by 1

Implementation of Nanocarriers for Brain-Specific Drug Delivery System

Sharma, A., Alam, A., & Kaur, A. (2023) · Current Nanomaterials · doi:10.2174/2405461508666230804102333 · Cited by 1

Hippocampal functional imaging-derived radiomics features for diagnosing cognitively impaired patients with Parkinson’s disease

Zeng, W., Liang, X., Guo, J., Cheng, W., Yin, Z., Hong, D., Li, F., Zhou, F., & Fang, X. (2025) · BMC Neuroscience · doi:10.1186/s12868-025-00938-8 · Cited by 1

Regulation of adult hippocampal neurogenesis by microglia in the healthy and injured brain

Fu, Z., RunZi, Y. A. N. G., & Hao, P. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0139 · Cited by 1

Mitochondrial Bioenergy in Neural Disease: Huntington and ParkinsonPreprint

Tassone, A., Meringolo, M., Bonsi, P., Schirinzi, T., & Martella, G. (2023) · Preprints.org · doi:10.20944/preprints202302.0015.v1

Caveolin-1 Autonomously Regulates Hippocampal Neurogenesis Via Mitochondrial DynamicsPreprint

Stephen, T. K. L., Cofresi, L. A., Quiroz, E., Owusu-Ansah, K., Ibrahim, Y., Qualls, E., Marshall, J., Li, W., Shetti, A., Bonds, J. A., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4529645 · Cited by 1

Deciphering molecular heterogeneity and dynamics of neural stem cells in human hippocampal development, aging, and injuryPreprint

Yao, J., Dai, S., Zhu, R., Tan, J., Zhao, Q., Yin, Y., Sun, J., Du, X., Ge, L., Xu, J., et al. (2023) · eLife · doi:10.7554/elife.89507.1 · Cited by 1

Caveolin-1 Regulates Neurogenesis and Learning and Memory by Modulation of Mitochondrial DynamicsPreprint

Stephen, T. K. L., Patel, D., Cofresi, L. A., Quiroz, E., Owusu-Ansah, K., Ibrahim, Y., Qualls, E., Marshall, J., Li, W., Kumar, P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.23.558792 · Cited by 1

Aberrant Hippocampal Neuroregenerative Plasticity in Schizophrenia: Reactive Neuroblostosis as a Possible Pathocellular Mechanism of HallucinationPreprint

Irakkam, M. P. B. D., Joseph, J. H. M., & Kandasamy, M. (2023) · Preprints.org · doi:10.20944/preprints202312.0820.v1

Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged MicePreprint

Chang, W.-L., Tegang, K., Samuels, B. A., Saxe, M., Wichmann, J., David, D. J. P., Mendez‐David, I., Augustin, A., Fischer, H., Golling, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.01.578406 · Cited by 1

Deciphering molecular heterogeneity and dynamics of neural stem cells in human hippocampal development, aging, and injuryPreprint

Yao, J., Dai, S., Zhu, R., Tan, J., Zhao, Q., Yin, Y., Sun, J., Du, X., Ge, L., Xu, J., et al. (2024) · eLife · doi:10.7554/elife.89507.2 · Cited by 1

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury statesPreprint

Yao, J., Dai, S., Zhu, R., Tan, J., Zhao, Q., Yin, Y., Sun, J., Du, X., Ge, L., Xu, J., et al. (2024) · eLife · doi:10.7554/elife.89507.3 · Cited by 1

Sequenced evidence

Quiniou, M., & Jessberger, S. (2025) · Science · doi:10.1126/science.ady8328 · Cited by 1

Pre-symptomatic reduction of individuality in the App NL-F knock-in model of Alzheimer’s diseasePreprint

Ehret, F., Pelz, M. S., Senko, A. N., Soto, K. E. G., Liu, H., & Kempermann, G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.18.504396

ADULTS NEUROGENESIS AS A RESERVE FOR HEALTH PRESERVATION

Tliashinova, I. A., Yusupova, M. M., Mingazov, R. N., Волкова, О. А., & Мингазова, Э. Н. (2022) · Problems of Social Hygiene Public Health and History of Medicine · doi:10.32687/0869-866x-2022-30-s1-1144-1149

Analysis of Adult Hippocampal Neurogenesis in Neurodegenerative disease

HAN, G. (2022) · Cronfa (Swansea University) · doi:10.23889/suthesis.62147

Desmuntant mites biològics a l'aula de ciències. Un recopilatori dels 70 més freqüents

Gómez Escrivá, D. (. ). (2023) · Universitat de València eBooks · doi:10.7203/puv-oa-552-8

Adult Neurogenesis: A Potential Target for Regenerative Medicine

Eradath, M. K. (2023) · Springer eBooks · doi:10.1007/978-981-19-6008-6_10

What can traditional Chinese medicine do for adult neurogenesis?

Shen, W., Jiang, N., & Zhou, W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1158228

Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by Derlin-1 through Maintenance of Adult NeurogenesisPreprint

Murao, N., Matsuda, T., Kadowaki, H., Matsushita, Y., Tanimoto, K., Katagiri, T., Nakashima, K., & Nishitoh, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.27.538634

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury statesPreprint

Yao, J., Dai, S., Zhu, R., Tan, J., Zhao, Q., Yin, Y., Sun, J., Du, X., Ge, L., Xu, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.15.540723

Orals

Hendriks, J. J. A. (2023) · Glia · doi:10.1002/glia.24418

In conversation with Rusty Gage

Wright, R. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01393-6

Resident Neural Stem Cells

Zaverucha-do-Valle, C., Gubert, F., Vasques, J. F., Mesentier-Louro, L. A., Scemes, E., Pitossi, F. J., Santiago, M. F., & Méndez‐Otero, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15289-4.00014-7

Methyl group donor reduces the Caffeine hippocampal anti-inflammatory effects and potentiates the LPS effect by positive transcription of the Nrf2/Txn1/Nlrp3 axisPreprint

Coque, A. D. C., Sanna, P. L. D. S., Carvalho, L. B., Scorzafav, A. A., Souza, J., de Miranda, T. B., Latini, A., Bernardi, M. M., Andia, D. C., da Silva, R. A., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4602127/v1

Adult neurogenesis in the hippocampus: A role in learning and memory

Kim, S. H., Yu, X., Christian, K. M., Ming, G., & Song, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00037-7

Convolutional Neural Networks for the segmentation of hippocampal structures in postmortem MRI scans

Anoop, B. N., Li, K., Honnorat, N., Rashid, T., Wang, D., Li, J., Fadaee, E., Charisis, S., Walker, J. M., Richardson, T. E., et al. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2024.110359

Stimulating SuM in mice with bad disease

Zhang, Q. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19368

Exploring the specific relationship between optogenetic activation of SuM-induced behavioural changes in AHNs and microglia for cognitive enhancement in mice

Shang, C. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19972

Adult Neurogenesis

Shtrahman, M., Parylak, S., Toda, T., & Gage, F. H. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0009

The link between microglia and adult hippocampal neurogenesis provides a new target for the intervention and treatment of neurodegenerative diseases

Cao, X. (2025) · BIO Web of Conferences · doi:10.1051/bioconf/202516601003

Isolation of Adult Hippocampal Neural Stem Cells

Martín‐Suárez, S. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4386-0_2

Hippocampal neural stem cells in Alzheimer’s disease: bridging neurogenesis, extracellular vesicles, and multimodal therapeutic paradigms

Li, R., Xiong, W., & Sun, C. (2025) · International Journal of Neuroscience · doi:10.1080/00207454.2025.2540989

Adults grow new brain cells – and these neurons are key to learning by listening

Ammothumkandy, A., Liu, C. Y., & Bonaguidi, M. A. (2024) · doi:10.64628/aai.mw7km4tdw

Deep learning-based magnetic resonance imaging image reconstruction in the assessment of brain microstructural changes in Parkinson's disease patients

Shao, J., & Wang, F. (2025) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2025.101876

Medicine

Kempermann, G. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197519233.003.0012

A Putative Role for the BCL2 Family of Proteins in the Pathophysiology of ALS

Nuovo, G. J., Crilly, C. J., Lietzke, A. C., & Sawant, D. B. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273426855250910082512

Analytical Review on Normal Brain Aging, Alzheimer’s Disease, and Stage 4S Neuroblastoma: Novel Insights Into Neuroprotection, Neurodegeneration, and Spontaneous Regression

Aygün, N. (2025) · Cureus · doi:10.7759/cureus.93818

The neuronal fate determinants SOX4/11 control mitotic fidelity of adult hippocampal precursor cellsPreprint

Adhikarla, S., Schäffner, I., Leal, A. L., Singh, S. K., Häberle, B. M., Turan, S., Sock, E., Sagner, A., & Lie, D. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.13.682016

Effects of lithium on brain oxidative stress in C57BL/6 mice subjected to paradoxical sleep deprivation and different rest periods

Hermann, R., Peper‐Nascimento, J., Possamai‐Della, T., Aguiar‐Geraldo, J. M., Plácido-Possamai, M. L., Machado-Laureano, M. L., Vitoreti-Vargas, A., & Valvassori, S. S. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.10.024

Sex‐Specific Neurogenic and Cognitive Responses in a Murine Model of Accelerated Aging

Gómez‐Oliva, R., Chamorro-Francisco, A., Atienza-Navarro, I., Carrascal, L., Freire-Aragon, M. D., Hernández‐Galán, R., Nunez‐Abades, P., Garcı́a-Alloza, M., & Castro, C. (2026) · Aging Cell · doi:10.1111/acel.70663

Chronic Gallic Acid Treatment Attenuates Hippocampal Neurodegeneration in Aged Rats

González‐Cano, S. I., Juárez-Serrano, D., Handal‐Silva, A., Morán-Perales, J. L., Vázquez‐Roque, R. A., Galindo-Ramírez, F., Treviño, S., Guevara, J., & Díaz, A. (2025) · Synapse · doi:10.1002/syn.70036

Insomnia‐Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization

Han, D., Li, X., Zhao, S., Liu, J., Wang, X., Jiang, Y., Ding, J., Wang, B., Cui, E., & Ding, H. (2026) · Health Science Reports · doi:10.1002/hsr2.71796

DNA damage-induced senescence reshapes transcriptomic and functional landscape of human neural progenitor cellsPreprint

Jose, N. V., Assir, M. Z. K., Soper, O., Janssens, S., Platt, B., & Kang, E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.29.721535

Integration of Metabolic Pathways and Micronutrient Signals Influences Neurodevelopment by Modulating Neural Stem Cell Dynamics

Chandini, S., Dey, D., Gulati, T., Mishra, A., & Adlakha, Y. K. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05904-x

Adult born hippocampal granule cells enhance dentate gyrus pattern separation via lateral inhibition

Wan, J., Wang, L., & Lai, H. (2025) · International Conference on Biomedical and Bioinformatics Engineering (ICBBE) · doi:10.1145/3794209.3794303

Citronellal improves ischemia-induced pathological senescence of hippocampal neurons and cognitive impairment via regulation of the TRPM2/NMDAR pathway

Fu, Z., Niu, Q., Zhang, C.-R., Wang, H.-D., Li, X.-Y., Li, C.-Z., Li, P., & Wang, Q. (2026) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2026.2676952

Quantifying Evidence for Competing Biomedical Hypotheses using Large Language Models and Bayesian AnalysisPreprint

Moore, B. M., Freeman, J., Millikin, R. J., Mohanty, C., George, K. W., Bal, A., Lock, C., Sauer, J., Spurgeon, M. E., Moore, D. L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.05.730173

Isolation of postnatal human neural stem cellsPreprint

Liu, D. D., Eastman, A. E., Womack-Gambrel, N. L., Kim, C. N., He, J. Q., Raj, S., Reilly, E. E., Sinha, R., Uchida, N., Chau, K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.11.731596

Microglia-centered cellular crosstalk in neurodegeneration

Huang, H., & Mass, E. (2026) · Advances in immunology · doi:10.1016/bs.ai.2026.06.001

Hippocampal C5a-C5aR1 axis drives age-related memory decline via collapsing synaptic chloride homeostasis

Liu, W., Qin, W., Li, Y., & Jia, J. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106888

Hippocampal Hbα deficiency induces neuronal apoptosis by promoting the accumulation of AGEs

Zhou, Y., Jiang, L., Zhang, Y., Wang, Y., Zhang, L., Zhou, C., Wang, S., Li, J., 胡春年, Luo, Y., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179139

Adult neural stem cell pools in homeostasis and pathogenesis

Li, S., Shi, X., Sun, X., & Wu, Q. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103685

Exercise as a Systemic Prevention and Management for Alzheimer’s Disease: Restoring Brain–Body Homeostasis Through Metabolic, Neurovascular, Anti-Inflammatory, and Regenerative Mechanisms

Xiao, L., Green, J. M., Mochizuki, M., & Nakahara, T. (2026) · Cells · doi:10.3390/cells15151368

Increased Binding of [ 18 F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Mukherjee, J., Karim, F., Ngo, A., Liang, C., Serrano, G. E., & Beach, T. G. (2026) · Synapse · doi:10.1002/syn.70053

Revealing the Mechanisms of Alzheimer’s, Parkinson’s and Huntington’s Diseases Through Invertebrate Models

Ding, X., Wang, P., Zhou, L., & Li, X. (2026) · Biology · doi:10.3390/biology15161351

Developmental brain programmes and biomarker activation in Alzheimer’s disease

Pini, L., Margoni, M., Filippi, M., & Imbimbo, B. P. (2026) · Brain Communications · doi:10.1093/braincomms/fcag337

Advances and discoveries in cognitive neurosciences

Rodriguez, R. V., & Kannan, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36544-7.00003-3

Hippocampal transcriptomic remodeling following heat stress implicates complement and coagulation pathways in neural stem cell-associated responsesPreprint

Ming, R., Li, Y., Wu, Z., Guo, H., Li, B., & Pan, S. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7513480

Ablation of the choroid plexus attenuates hydrocephalus-induced parenchymal edema with moderate reduction of postnatal hippocampal neurogenesis

Таранов, А., Mayrhofer, F., Hamm, S., Kniffen, E., Peter, J., Wallace, F., Lullmann, O., McClain, L., Chechneva, O. V., Sadegh, C., et al. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00882-7

Enzyme‐Digested Edible Bird's Nest Promotes NGF‐Induced Differentiation of PC12 Cells by Activating the TrkA‐ERK1/2‐CREB‐BDNF Signaling Pathway

Zhang, W., Wang, X., Zhu, H., Lin, X., Li, R., Yuan, M., Xu, B., Wang, D., Xiong, W., & Li, Y. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72419

Epileptik Beynin Morfolojisi ve Rehabilitasyonun Anatomik Dayanakları

Karsli, M. A. (2026) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1522

Neuronal Overexpression of Glycogen Synthase Kinase‐3β Accelerates Age‐Related Glial, Vascular, and Inflammatory Remodeling of the Murine Dentate Gyrus

Prádanos-Senén, A. V., Rodríguez-Moreno, C. B., & Llorens-Martı́n, M. (2026) · Glia · doi:10.1002/glia.70248

BindingDB Entry 50015382: Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.

BindingDB (2023) · UC San Diego · doi:10.7270/q2f76hgt

Berberine improves cognitive impairment in diabetic mice by mitigating 4-HNE-induced oxidative stress and enhancing hippocampal insulin sensitivity

Gupta, M., Rumman, M., Mahdi, A. A., & Pandey, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-13042-9

Human adult hippocampal neurogenesis in health and disease

Alonso-Moreno, M. C., Gallardo‐Caballero, M., Prádanos-Senén, A. V., & Llorens-Martı́n, M. (2025) · Aging Brain · doi:10.1016/j.nbas.2025.100145 · Cited by 11

Neurogenesis altered in multiple neurodegenerative diseases

Fyfe, I. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00588-4 · Cited by 1

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577

Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?

Thompson, A., Boekhoorn, K., Van Dam, A. ‐., & Lucassen, P. J. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00379.x · Cited by 73

Adult hippocampal neurogenesis and its impairment in Alzheimer’s disease

Kim, T. A., Syty, M. D., Wu, K., & Ge, S. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2021.479 · Cited by 116