The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Taurine deficiency as a driver of aging
Open accessAbstract
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
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1 retracted
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Cited by
Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging
Lapenna, D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102066 · Cited by 239
Wu, Z., Qu, J., & Liu, G.-H. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00775-3 · Cited by 118
Is taurine an aging biomarker?
Fernandez, M. E., Bernier, M., Price, N. L., Camandola, S., Aon, M. A., Vaughan, K., Mattison, J. A., Preston, J. D., Jones, D. P., Tanaka, T., et al. (2025) · Science · doi:10.1126/science.adl2116 · Cited by 33
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Jankowski, C. S. R., Samarah, L. Z., MacArthur, M. R., Mitchell, S. J., Weilandt, D. R., Hunter, C. J., Zeng, X., McReynolds, M. R., & Rabinowitz, J. D. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.009 · Cited by 19
Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages
Guan, C., Ryu, S., Dong, M., Zhu, Y., Maeda, R., Youm, Y.-H., Mohanty, S., Kim, H.-H., Orliaguet, L., Dlugos, T., et al. (2026) · Cell · doi:10.1016/j.cell.2026.09.061
Metadata
- Authors
- Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Lopes Bastos, B., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., Sharan, K., Chinta, S. J., Rajput, S., Rane, A., Baumert, P., Schönfelder, M., Iavarone, F., di Lorenzo, G., Kumari, S., Gupta, A., Sarkar, R., Khyriem, C., Chawla, A. S., Sharma, A., Sarper, N., Chattopadhyay, N., Biswal, B. K., Settembre, C., Nagarajan, P., Targoff, K. L., Picard, M., Gupta, S., Velagapudi, V., Papenfuss, A. T., Kaya, A., Ferreira, M. G., Kennedy, B. K., Andersen, J. K., Lithgow, G. J., Ali, A. M., Mukhopadhyay, A., Palotie, A., Kastenmüller, G., Kaeberlein, M., Wackerhage, H., Pal, B., & Yadav, V. K.
- Venue
- Science
- Published
- 2023-06-09
- Volume
- 380
- Issue
- 6649
- Pages
- eabn9257-eabn9257
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4379794190
- Cited by
- 435
- References
- 129
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Lopes Bastos, B., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., . . . Yadav, V. K. (2023). Taurine deficiency as a driver of aging. Science. https://doi.org/10.1126/science.abn9257
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
