The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
NIN-like protein 7 transcription factor is a plant nitrate sensor
Open accessAbstract
Nitrate is an essential nutrient and signaling molecule for plant growth. Plants sense intracellular nitrate to adjust their metabolic and growth responses. Here we identify the primary nitrate sensor in plants. We found that mutation of all seven Arabidopsis NIN-like protein (NLP) transcription factors abolished plants’ primary nitrate responses and developmental programs. Analyses of NIN-NLP7 chimeras and nitrate binding revealed that NLP7 is derepressed upon nitrate perception via its amino terminus. A genetically encoded fluorescent split biosensor, mCitrine-NLP7, enabled visualization of single-cell nitrate dynamics in planta. The nitrate sensor domain of NLP7 resembles the bacterial nitrate sensor NreA. Substitutions of conserved residues in the ligand-binding pocket impaired the ability of nitrate-triggered NLP7 to control transcription, transport, metabolism, development, and biomass. We propose that NLP7 represents a nitrate sensor in land plants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Floral dip: a simplified method forAgrobacterium‐mediated transformation ofArabidopsis thaliana
Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 21,934
Enzymatic assembly of DNA molecules up to several hundred kilobases
Gibson, D. G., Young, L., Chuang, R.-Y., Venter, J. C., Hutchison, C. A., & Smith, H. O. (2009) · Nature Methods · doi:10.1038/nmeth.1318 · Cited by 9,996
Accurate prediction of protein structures and interactions using a 3-track network
Baek, M., DiMaio, F., Anishchenko, I., Dauparas, J., Ovchinnikov, S., Lee, G. R., Wang, J., Cong, Q., Kinch, L. N., Schaeffer, R. D., et al. (2021) · doi:10.1101/2021.06.14.448402 · Cited by 5,549
Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis
Yoo, S.-D., Cho, Y.-H., & Sheen, J. (2007) · Nature Protocols · doi:10.1038/nprot.2007.199 · Cited by 5,083
Self-citationpGreen: a versatile and flexible binary Ti vector for Agrobacterium-mediated plant transformation
Hellens, R. P., Edwards, E. A., Leyland, N. R., Bean, S., & Mullineaux, P. M. (2000) · Plant Molecular Biology · doi:10.1023/a:1006496308160 · Cited by 1,562
CHL1 Functions as a Nitrate Sensor in Plants
Ho, C.-H., Lin, S.-H., Hu, H.-C., & Tsay, Y.-F. (2009) · Cell · doi:10.1016/j.cell.2009.07.004 · Cited by 1,329
Differential innate immune signalling via Ca2+ sensor protein kinases
Boudsocq, M., Willmann, M. R., McCormack, M., Lee, H., Shan, L., He, P., Bush, J., Cheng, S.-H., & Sheen, J. (2010) · Nature · doi:10.1038/nature08794 · Cited by 887
Self-citationNitrogen transformations in modern agriculture and the role of biological nitrification inhibition
Coskun, D., Britto, D. T., Shi, W., & Kronzucker, H. J. (2017) · Nature Plants · doi:10.1038/nplants.2017.74 · Cited by 731
Nitrate Transport, Signaling, and Use Efficiency
Wang, Y.-Y., Cheng, Y.-H., Chen, K.-E., & Tsay, Y.-F. (2018) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042817-040056 · Cited by 657
Research works printed but not linked: 7
- 10.1016/j.pbi.2015.03.002 · doi:10.1016/j.pbi.2015.03.002
- 10.1111/j.1365-313X.2008.03443.x · doi:10.1111/j.1365-313x.2008.03443.x
- 10.1111/j.1365-313X.2010.04239.x · doi:10.1111/j.1365-313x.2010.04239.x
- 10.1093/jxb/erab246 · doi:10.1093/jxb/erab246
- 10.1016/j.bbrc.2011.07.008 · doi:10.1016/j.bbrc.2011.07.008
- 10.1126/science.abj8754 · doi:10.1126/science.abj8754 · Paper page
- 10.1007/978-1-4939-8760-3_11 · doi:10.1007/978-1-4939-8760-3_11
Cited by
Chen, Y., Li, Y., Fu, Y., Jia, L., Li, L., Xu, Z., Zhang, N., Liu, Y., Fan, X., Xuan, W., et al. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae125 · Cited by 31
Zhou, J., Liu, H., Hu, L., Kagami, H., & Wang, S. (2024) · Medicine Plus · doi:10.1016/j.medp.2023.100003 · Cited by 17
Dynamic changes in mRNA nucleocytoplasmic localization in the nitrate response of Arabidopsis roots
(2024) · doi:10.1111/pce.15018 · Cited by 9
Metadata
- Authors
- Liu, K.-H., Liu, M., Lin, Z., Wang, Z.-F., Chen, B., Liu, C., Guo, A., Konishi, M., Yanagisawa, S., Wagner, G., & Sheen, J.
- Venue
- Science
- Published
- 2022-09-23
- Volume
- 377
- Issue
- 6613
- Pages
- 1419-1425
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4296802323
- Cited by
- 284
- References
- 39
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: NIN-like protein 7 transcription factor is a plant nitrate sensor. https://app.cochat.ai/papers/10.1126/science.add1104
- The paper
- Liu, K.-H., Liu, M., Lin, Z., Wang, Z.-F., Chen, B., Liu, C., Guo, A., Konishi, M., Yanagisawa, S., Wagner, G., & Sheen, J. (2022). NIN-like protein 7 transcription factor is a plant nitrate sensor. Science. https://doi.org/10.1126/science.add1104
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
