Probiotic-guided CAR-T cells for solid tumor targeting

Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer

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Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

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The human tumor microbiome is composed of tumor type–specific intracellular bacteria

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A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

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The microbiome and human cancer

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Tumor Antigen Escape from CAR T-cell Therapy

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The Principles of Engineering Immune Cells to Treat Cancer

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Engineering the perfect (bacterial) cancer therapy

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Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

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Tumour-targeting bacteria engineered to fight cancer

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Synchronized cycles of bacterial lysis for in vivo delivery

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Phase I Study of the Intravenous Administration of AttenuatedSalmonella typhimuriumto Patients With Metastatic Melanoma

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Programmable bacteria induce durable tumor regression and systemic antitumor immunity

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Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

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Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

Cho, J. H., Collins, J. J., & Wong, W. W. (2018) · Cell · doi:10.1016/j.cell.2018.03.038 · Cited by 685 · see citing works

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Gurbatri, C. R., Lia, I., Vincent, R., Coker, C., Castro, S., Treuting, P. M., Hinchliffe, T. E., Arpaia, N., & Danino, T. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax0876 · Cited by 647 · see citing works

Phase I Study of the Intravenous Administration of Attenuated Salmonella typhimurium to Patients With Metastatic Melanoma

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T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells

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Two-step enhanced cancer immunotherapy with engineered <i>Salmonella typhimurium</i> secreting heterologous flagellin

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CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

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Microbiota of Human Breast Tissue

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Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

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Programmable probiotics for detection of cancer in urine

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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

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Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

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Acute Inflammatory Response to Endotoxin in Mice and Humans

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Direct Stimulation of Human T Cells via TLR5 and TLR7/8: Flagellin and R-848 Up-Regulate Proliferation and IFN-γ Production by Memory CD4+ T Cells

Caron, G., Duluc, D., Frémaux, I., Jeannin, P., David, C., Gascan, H., & Delneste, Y. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1551 · Cited by 410 · see citing works

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

Davenport, A. J., Cross, R. S., Watson, K. A., Liao, Y., Shi, W., Prince, H. M., Beavis, P. A., Trapani, J. A., Kershaw, M. H., Ritchie, D., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716266115 · Cited by 353 · see citing works

Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors

Park, A. K., Fong, Y., Kim, S., Yang, J., Murad, J. P., Lu, J., Jeang, B., Chang, W.-C., Chen, N. G., Thomas, S. H., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz1863 · Cited by 273 · see citing works

High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model

Richman, S. A., Nuñez-Cruz, S., Moghimi, B., Li, L. Z., Gershenson, Z. T., Mourelatos, Z., Barrett, D. M., Grupp, S. A., & Milone, M. C. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0211 · Cited by 269 · see citing works

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

Harimoto, T., Hahn, J., Chen, Y., Im, J., Zhang, J. T., Hou, N. Y., Li, F., Coker, C., Gray, K., Harr, N., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01244-y · Cited by 262 · see citing works

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

Chang, Z. L., Lorenzini, M. H., Chen, X., Tran, U., Bangayan, N. J., & Chen, Y. Y. (2018) · Nature Chemical Biology · doi:10.1038/nchembio.2565 · Cited by 259 · see citing works

Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus–Driven Production of a Bispecific T-cell Engager

Wing, A., Fajardo, C. A., Posey, A. D., Shaw, C. E., Da, T., Young, R. M., Alemany, R., June, C. H., & Guedan, S. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0314 · Cited by 253 · see citing works

Modulating the innate immune response by combinatorial engineering of endotoxin

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Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

Labanieh, L., Majzner, R. G., Klysz, D. D., Sotillo, E., Fisher, C., Vilches-Moure, J. G., Pacheco, K. Z., Malipatlolla, M. B., Xu, P., Hui, J. H., et al. (2022) · Cell · doi:10.1016/j.cell.2022.03.041 · Cited by 227 · see citing works

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

Momin, N., Mehta, N. K., Bennett, N. R., Ma, L., Palmeri, J. R., Chinn, M. M., Lutz, E. A., Kang, B. H., Irvine, D. J., Spranger, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw2614 · Cited by 205 · see citing works

ICAM-1 as a molecular target for triple negative breast cancer

Guo, P., Huang, J., Wang, L., Jia, D., Yang, J., Dillon, D. A. R., Zurakowski, D., Mao, H. Z., Moses, M. A., & Auguste, D. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408556111 · Cited by 192 · see citing works

Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies

Luke, J. J., Piha-Paul, S. A., Medina, T. M., Verschraegen, C. F., Varterasian, M. L., Brennan, A. M., Riese, R. J., Sokolovska, A., Strauss, J. F., Hava, D. L., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0118 · Cited by 188 · see citing works

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Lesch, S., Blumenberg, V., Stoiber, S., Gottschlich, A., Ogonek, J., Cadilha, B. L., Dantes, Z., Rataj, F., Dorman, K., Lutz, J., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00737-6 · Cited by 183 · see citing works

Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models

Mata, M., Gerken, C. P., Nguyen, P., Krenciute, G., Spencer, D. M., & Gottschalk, S. M. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0263 · Cited by 180 · see citing works

Enhancing the tropism of bacteria via genetically programmed biosensors

Chien, T., Harimoto, T., Kepecs, B., Gray, K., Coker, C., Hou, N. Y., Pu, K., Azad, T., Nolasco, A., Pavlicová, M., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00772-3 · Cited by 169 · see citing works

Chemokines expressed by engineered bacteria recruit and orchestrate antitumor immunity

Savage, T. M., Vincent, R. L., Rae, S. S., Huang, L., Ahn, A., Pu, K., Li, F., Santos, K. D. L., Coker, C., Danino, T., et al. (2023) · Science Advances · doi:10.1126/sciadv.adc9436 · Cited by 166 · see citing works

Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity

Park, S., Shevlin, E., Vedvyas, Y., Zaman, M., Park, S., Hsu, Y.-M. S., Min, I. M., & Jin, M. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-14749-3 · Cited by 164 · see citing works

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Ishihara, J., Fukunaga, K., Ishihara, A., Larsson, H. M., Potin, L., Hosseinchi, P., Galliverti, G., Swartz, M. A., & Hubbell, J. A. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan0401 · Cited by 155 · see citing works

Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control

Miller, I. C., Zamat, A. H., Sun, L.-K., Phuengkham, H., Harris, A. M., Gamboa, L., Yang, J., Murad, J. P., Priceman, S. J., & Kwong, G. A. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00781-2 · Cited by 148 · see citing works

Driving CARs on the uneven road of antigen heterogeneity in solid tumors

Chen, N., Li, X., Chintala, N. K., Tano, Z. E., & Adusumilli, P. S. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.03.002 · Cited by 143 · see citing works

Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment

Sukumaran, S., Watanabe, N., Bajgain, P., Raja, K., Mohammed, S., Fisher, W. E., Brenner, M. K., Leen, A. M., & Vera, J. F. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1298 · Cited by 128 · see citing works

Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity

Murad, J. P., Tilakawardane, D., Park, A. K., Lopez, L. S., Young, C. A., Gibson, J., Yamaguchi, Y., Lee, H. J., Kennewick, K. T., Gittins, B. J., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.024 · Cited by 113 · see citing works

DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

Huang, X., Williams, J. Z., Chang, R., Li, Z., Burnett, C. E., Hernández-López, R. A., Setiady, I., Gai, E., Patterson, D. M., Yu, W., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-00813-z · Cited by 111 · see citing works

Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma

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Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

Zhang, A. Q., Hostetler, A., Chen, L. E., Mukkamala, V., Abraham, W. D., Padilla, L. T., Wolff, A. N., Maiorino, L., Backlund, C. M., Aung, A., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01048-8 · Cited by 91 · see citing works

Engineering advanced cancer therapies with synthetic biology

Wu, M.-R., Jusiak, B., & Lu, T. K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0121-0 · Cited by 90 · see citing works

Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model

Idorn, M., Skadborg, S. K., Kellermann, L., Halldórsdóttir, H. R., Olofsson, G. H., Met, Ö., & Straten, P. T. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1450715 · Cited by 77 · see citing works

A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers

Gniadek, T. J., Augustin, L. B., Schottel, J. L., Leonard, A. S., Saltzman, D. A., Greeno, E. W., & Batist, G. (2020) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000325 · Cited by 77 · see citing works

Engineering CAR-T cells to activate small-molecule drugs in situ

Gardner, T. J., Lee, J. P., Bourne, C. M., Wijewarnasuriya, D., Kinarivala, N., Kurtz, K. G., Corless, B. C., Dacek, M. M., Chang, A. Y., Mo, G., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00932-1 · Cited by 76 · see citing works

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Jin, C., Ma, J., Ramachandran, M., Yu, D., & Essand, M. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00875-5 · Cited by 61 · see citing works

Two New Plasmid Post-segregational Killing Mechanisms for the Implementation of Synthetic Gene Networks in Escherichia coli

Fedorec, A. J. H., Ozdemir, T., Doshi, A., Ho, Y.-K., Rosa, L., Rutter, J. W., Velazquez, O. S., Pinheiro, V. B., Danino, T., & Barnes, C. P. (2019) · iScience · doi:10.1016/j.isci.2019.03.019 · Cited by 57 · see citing works

Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin

Wagner, J., Wickman, E., Shaw, T. I., Anido, A. A., Langfitt, D. M., Zhang, J., Porter, S. N., Pruett‐Miller, S. M., Tillman, H. S., Krenciute, G., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0280 · Cited by 46 · see citing works

Thermal Control of Engineered T-cells

Abedi, M. H., Lee, J. W., Piraner, D. I., & Shapiro, M. G. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00238 · Cited by 40 · see citing works

TLR5 Ligand–Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity

Geng, D., Kaczanowska, S., Tsai, A., Younger, K., Ochoa, A. C., Rapoport, A. P., Ostrand-Rosenberg, S., & Dávila, E. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2467 · Cited by 36 · see citing works

A Suite of Engineered GFP Molecules for Oligomeric Scaffolding

Leibly, D. J., Arbing, M. A., Pashkov, I., DeVore, N. M., Waldo, G. S., Terwilliger, T. C., & Yeates, T. O. (2015) · Structure · doi:10.1016/j.str.2015.07.008 · Cited by 35 · see citing works

Paving New Roads for CARs

Wittsten, A. H., & Roybal, K. T. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.09.005 · Cited by 27 · see citing works

Myristoylation negative msbB-mutants of probiotic E. coli Nissle 1917 retain tumor specific colonization properties but show less side effects in immunocompetent mice

Stritzker, J., Hill, P. J., Gentsche, I., & Szalay, A. A. (2010) · Bioengineered Bugs · doi:10.4161/bbug.1.2.10286 · Cited by 26 · see citing works

Characterization of camel nanobodies specific for superfolder GFP fusion proteins

Twair, A., Al-Okla, S., Zarkawi, M., & Abbady, A. Q. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3575-x · Cited by 22 · see citing works

Virulence-attenuated Salmonella engineered to secrete immunomodulators reduce tumour growth and increase survival in an autochthonous mouse model of breast cancer

Augustin, L. B., Milbauer, L. C., Hastings, S. E., Leonard, A. S., Saltzman, D. A., & Schottel, J. L. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1850739 · Cited by 12 · see citing works

Sensitizing solid tumors to CAR-mediated cytotoxicity using synthetic antigensPreprint

Gamboa, L., Zamat, A. H., Vanover, D. A., Thiveaud, C. A., Peck, H. E., Phuengkham, H., Sivakumar, A., Harris, A. M., Dahotre, S. N., Su, F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.11.472238 · Cited by 4 · see citing works

Cancer treatments: Past, present, and future

Sonkin, D., Thomas, A., & Teicher, B. A. (2024) · Cancer Genetics · doi:10.1016/j.cancergen.2024.06.002 · Cited by 559 · see citing works

Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control

Lu, L., Xie, M., Yang, B., Zhao, W., & Cao, J. (2024) · Science Advances · doi:10.1126/sciadv.adj6251 · Cited by 117 · see citing works

Bacterial immunotherapy leveraging IL-10R hysteresis for both phagocytosis evasion and tumor immunity revitalization

Chang, Z., Guo, X., Li, X., Wang, Y., Zang, Z., Pei, S., Lu, W., Li, Y., Huang, J., Xiao, Y., et al. (2025) · Cell · doi:10.1016/j.cell.2025.02.002 · Cited by 112 · see citing works

Melanoma and microbiota: Current understanding and future directions

Routy, B., Jackson, T., Mählmann, L., Baumgartner, C. K., Blaser, M., Byrd, A., Corvaia, N., Couts, K., Davar, D., Derosa, L., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2023.12.003 · Cited by 89 · see citing works

Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses

Yang, S., Sheffer, M., Kaplan, I. E., Wang, Z., Tarannum, M., Dinh, K., Abdulhamid, Y., Bobilev, E., Shapiro, R., Porter, R., et al. (2025) · Nature Biotechnology · doi:10.1038/s41587-024-02418-6 · Cited by 66 · see citing works

Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms

Li, F., Yang, Z., Savage, T. M., Vincent, R. L., Santos, K. D. L., Ahn, A., Rouanne, M., Mariuzza, D. L., Danino, T., & Arpaia, N. (2024) · Science Immunology · doi:10.1126/sciimmunol.adn9879 · Cited by 59 · see citing works

Tannic acid-based metal-phenolic networks as a versatile platform to mediate cell therapy

Luo, H., Xie, J., Su, X., Wang, P., Chen, H., Kuang, X., & Liu, J. (2024) · Science China Materials · doi:10.1007/s40843-024-3139-3 · Cited by 59 · see citing works

Intratumoral Microbiota as a Target for Advanced Cancer Therapeutics

Peng, F., Hu, M., Su, Z., Hu, L., Guo, L., & Yang, K. (2024) · Advanced Materials · doi:10.1002/adma.202405331 · Cited by 57 · see citing works

Innovative Applications of Bacteria and Their Derivatives in Targeted Tumor Therapy

Zhu, D., Pan, W. X., Li, H., Hua, J., Zhang, C., & Zhao, K. (2025) · ACS Nano · doi:10.1021/acsnano.4c15237 · Cited by 56 · see citing works

Microbe-material hybrids for therapeutic applications

Chen, M., Xia, L., Wu, C., Wang, Z., Ding, L. S., Xie, Y., Feng, W., & Chen, Y. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00655g · Cited by 55 · see citing works

SynNotch CAR-T cell, when synthetic biology and immunology meet again

Shirzadian, M., Moori, S., Rabbani, R., & Rahbarizadeh, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1545270 · Cited by 55 · see citing works

The tumor microbiome in cancer progression: mechanisms and therapeutic potential

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